expressed by SKM at relatively high levels (β2-adrenergic receptor and CRF2 receptor) and studied the acute metabolic The acute metabolic effects following agonist activation of β2-adrenergic and, potentially, CRF2 receptors appear primarily mediated by altered insulin release. The acute metabolic effects of UCN2 were not mediated by SKM Gs signaling.

synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling regulates cellular metabolism afferent and peripheral efferent signals that link specific neural cell populations to the regulation of metabolic Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic Variants identified in PKA subunit genes cause Cushing syndrome that is characterized by metabolic dysregulation

September 2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites

and drug resistance phenomenon applying metabolomics analyses. Claudia, who has an interest in metabolites and their effects on the system, agreed. Metabolite Activation of GPCRs: A Fascinating Discovery Claudia and Yamina discussed the role of metabolites metabolites and their receptors, particularly in relation to fermented foods. between metabolites, gut health, and disease progression.

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites To this end, we focused on analysis of bacterial metabolites that are currently recognized to bind to We further mapped the distribution of these molecules across the public mass spectrometry-based metabolomics from a public human protein atlas database, we inferred the most predominant GPCR-mediated microbial metabolite-human molecules across the druggable human GPCRome, a useful framework for integration of microbiome and metabolite

My research goal is to identify novel cellular target receptors of human gut microbe-derived metabolites research, I was part of a study that identified the receptors of a novel human gut microbe-derived metabolite discovered adrenergic receptors (α2A, α2B, and β2-adrenergic receptors) that serve as the gut microbial metabolite (PAG) receptor and characterized the receptor-metabolite interaction. identifying allosteric modulators of host G-protein-coupled receptors (GPCRs) that contribute to cardio-metabolic