expressed by SKM at relatively high levels (β2-adrenergic receptor and CRF2 receptor) and studied the acute metabolic The acute metabolic effects following agonist activation of β2-adrenergic and, potentially, CRF2 receptors appear primarily mediated by altered insulin release. The acute metabolic effects of UCN2 were not mediated by SKM Gs signaling.

synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling regulates cellular metabolism afferent and peripheral efferent signals that link specific neural cell populations to the regulation of metabolic Mouse models have provided invaluable information on the roles for PKA subunits in brain and key metabolic Variants identified in PKA subunit genes cause Cushing syndrome that is characterized by metabolic dysregulation

September 2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites

October 2022 "Background: Uncoupling proteins (UCPs) are unpaired electron carriers that uncouple oxygen intake by the electron transport chain from ATP production in the inner membrane of the mitochondria. The physiological activities of UCPs have been hotly contested, and the involvement of UCPs in the pathogenesis and progression of diabetes mellitus is among the greatest concerns. UCPs are hypothesised to be triggered by superoxide and then reduce mitochondrial free radical production, potentially protecting diabetes mellitus patients who are experiencing oxidative stress. Objectives: The objectives of the study are to find out the newest ways to treat diabetes mellitus through protein uncoupling." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Recurrent hypoglycemia increases hepatic gluconeogenesis without affecting glycogen metabolism Whether and how RH affects responses within metabolically important peripheral organs to counterregulatory Objective: To study the effects of RH on metabolic pathways associated with glucose counterregulation G-protein coupled receptors (GPCRs), their inhibitory regulators and downstream enzymes catalyzing glycogen metabolism

September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism calibrate glucagon-like peptide 1 (GLP-1) bioavailability, thereby regulating systemic glucose and lipid metabolism -1R) is not required for enteroendocrine L cell GLP-1 secretion and glucose homeostasis nor for the metabolic

October 2022 N-terminal alterations turn the gut hormone GLP-2 into an antagonist with gradual loss of

March 2022 Inversago Pharma Announces Dosing of First Participant with Metabolic Syndrome in Phase 1B unique portfolio of CB1 inverse agonists, announced today the dosing of the first participant with metabolic pharmacokinetics and safety profile of Inversago’s lead molecule, INV-202, on a targeted population with metabolic

However, our knowledge of how GPCRs regulate liver metabolism and fibrosis in the different cell types

Exendin-4 Attenuates Remodeling in the Remote Myocardium of Rats After an Acute Myocardial Infarction β-Catenin Purpose: This study tested if the protective anti-remodeling effect of GLP-1 agonist Exendin-4 after Exendin-4 to MI rats reduced the infarct size and reversed the aforementioned signaling molecules without altering After MI, TGF-β1, and Wnt 1 levels are significantly increased, the overproduction of Wnt1 induces β-catenin

Experimental studies proposed a direct effect of follicle-stimulating hormone (FSH) on the skeletal metabolism

Studies and Biological Assays GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism Diversity, and Biological Activity Advances in steroid research from the pioneering neurosteroid concept to metabolomics American Physiology Summit April 5 - 10, 2024 | AACR Annual Meeting April 22 - 23, 2024 | Endocrine Metabolic Schmeizl NEW Scientist NEW Lead Researcher NEW Post-Doctoral Fellow Sr Scientist in Obesity, Muscle, and Metabolism

The move comes less than three weeks after X4 pulled together a $55 million PIPE and amended a loan facility

Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

autonomic nervous system receptors Methods & Updates in GPCR Research Multi-tissue transcriptomic and serum metabolomic

We will be offering this live course again later this year. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. from  February 19th to 25th, 2024 Adhesion GPCRs The Adhesion GPCR and PCP component Flamingo (FMI-1) alters histamine H3 receptor isoforms Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3 After

in various physiological functions, such as sensory perception, reproduction, development, growth, metabolism , and are also linked to major diseases, such as neuroinflammatory, metabolic and autoimmune diseases Some studies have also reported GPR84 involvement in pain, atherosclerosis, and even metabolic disorders IM (3,3′‐methylenebis‐1H‐indole) has been identified as a positive allosteric modulator of GPR84, a metabolite

You can still join this waitlist and be the first to know when the live course is offered later this April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join Dr. GPCR founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. antidepressant drug treatment: impacts on metabolism of polyamines, mRNA splicing, regulation of RAS are itching to specialize A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like

Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for metabolic The human islet GPCRome is not a static entity, but one that is altered under pathophysiological conditions We have also considered the likely outcomes on islet function that the altered GPCR expression status possible impact that adipokines, secreted from expanded fat depots, could have at those GPCRs showing altered

G-protein activation via phosphorylation mediated non-canonical pathway GPCR Screening Reveals that the Metabolite therapeutic target for CNS disorders - an in silico approach GRN knockdown regulates the expression and alternative for stabilization Cryo-electron microscopy for GPCR research and drug discovery in endocrinology and metabolism

We will be offering this live course later this year. April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join our Founder Dr. Yamina Berchiche at the Endocrine Metabolic GPCRs event in Birmingham, UK, on April 22-23, 2024. Doxorubicin alters G-protein coupled receptor-mediated vasocontraction in rat coronary arteries GPCRs involved in metabolic diseases: pharmacotherapeutic development updates Methods & Updates in GPCR Research

is true for the glucagon receptor (GCGR), which mediates physiological regulation of hepatic glucose metabolism epitope-tagged GCGRs undergo clathrin- and dynamin-dependent endocytosis in HEK293 and Huh-7-Lunet cells after Together, these results implicate the endosomal signaling paradigm in metabolic regulation by glucagon

April 22 - 23, 2024 | Endocrine Metabolic GPCRs Join us at the Endocrine Metabolic GPCRs event on April in Cardiology, Endocrinology, and Taste Propionate functions as a feeding-state-dependent regulatory metabolite

an important subclass of GPCRs that include 15 receptors involved in regulating body homeostasis and metabolism dimerization is critical for regulating GPCR function, particularly with respect to biased agonism, which may alter therapeutic agents that target specific receptor dimer states to modulate signaling in diseases related to metabolism Schelshorn, D., et al., Lateral allosterism in the glucagon receptor family: glucagon-like peptide 1

January 2022 "After securing FDA approval for Wegovy last year, Novo Nordisk is strengthening its position work with EraCal to identify novel drug targets relevant for food intake regulation and additional metabolic

After discussing the fundamentals and applications of mutagenesis in GPCR studies (Lu, 2024), a case Alternatively, allosteric modulators , which bind to sites outside the traditional ligand-binding pocket including β2AR, play key roles in various conditions, such as asthma, cardiovascular diseases, and metabolic

Adhesion GPCRs Novel Isoforms of Adhesion G Protein-Coupled Receptor B1 (ADGRB1/BAI1) Generated from an Alternative the field of metabotropic glutamate receptors Molecular Basis of MC1R Activation: Mutation-Induced Alterations encoding protomers of the 5-HT 2A -mGlu2 receptor complex in living cells GPCRs in Oncology and Immunology Metabolic

First metabolic profiling of 4-n-nonylphenol in human liver microsomes by integrated approaches to testing and assessment: Metabolites, pathways, and biological effects.