GPCRs in Oncology and Immunology GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis Through gain- and loss-of-function studies in mice, we show that GPR143 promotes metastasis by secreting Tags GPR143 , HRS , MVB , breast cancer , exosomal protein sorting , exosome biogenesis , melanoma , metastasis

"The accumulation of ascites in patients with ovarian cancer increases their risk of transcoelomic metastasis restriction of ascites accumulation as maintenance strategies for overcoming mechanotransduction-mediated metastasis glycocalyx , high grade serous ovarian cancer , mechanotransduction , mucin 15 (MUC15) , transcoelomic metastasis

Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing Olfactory receptors , Therapeutic targeting , Tumor cell proliferation , Tumor development , Tumor metastasis

In cancer, chemokines play paradoxical roles in both the directed emigration of metastatic, receptor-expressing Drouillard, Brian T Craig, Michael B Dwinell Tags Chemokine receptor; cell migration; immuno-oncology; metastasis

melanoma cells in the tumor microenvironment Published date December 23, 2022 Abstract Due to its high metastatic tumor microenvironment (= TME, inverse pH-gradient) is a well-known driver of tumor progression and metastasis

GIV/Girdin has emerged as a prototypical non-GPCR activator of G proteins that promotes cancer metastasis thereby blocking noncanonical G-protein signaling in tumor cells and inhibiting proinvasive traits of metastatic

, 2024 Abstract "G protein-coupled receptors (GPCRs) are essential contributors to tumor growth and metastasis

P2Y12R is involved in cancer development and metastasis, while P2Y12R inhibitors are effective in inhibiting

Authors Katrin Sak Tags Carcinogenesis , GPR87 , LPA receptor , Metastasis , Orphan GPCR , P2Y receptor

types of cancer and is involved in several cancer phenotypes including tumor growth, survival, and metastasis

to pro-inflammation and induces the pro-inflammatory phenotype of VSMCs that is favorable for tumor metastasis

Flowcytometry and Transwell assays were performed to observe the changes in cell apoptosis, metastasis

protein-coupled receptor (GPCR) pathways which have been described to support growth, invasiveness, and metastasis

In contrast, during metastasis, where invasion is the primary task, the isoform switches back to the

indispensable for the activation and trafficking of inflammatory mediators and tumor progression and metastasis

CXCR4) and its ligand CXCL12, both of which are overexpressed in many cancers, play a pivotal role in metastasis

Cell Signaling and Cancer Metastasis Discussion Aurelien Rizk and Yamina Berchiche had a detailed conversation fascination of understanding how cells respond to gradients and signals, particularly in relation to cancer metastasis

Evaluation of receptors expression dynamics was performed for tumor-nodes-metastases (TNM) defined subgroups However, an unexpected upregulation of both SST2 and SST3 reemerged in metastases suggesting conserved

overexpressed in many solid breast cancers, and its levels in prostate cancer significantly correlate with the metastatic

contribution to the progression of cancers, such as prostate and ovarian cancer, facilitating the invasive and metastatic

worked in the EuGEF Research Group to identify novel prognostic biomarkers and therapeutic options for Metastatic