In an in vivo study, the effects of RGS6 knockout were studied in a mouse model of ALI induced by lipopolysaccharide Authors Juan Song , Miao Li , Cuicui Chen , Jian Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin

To investigate potential mechanisms underlying this synergistic pharmacodynamic interaction, liquid chromatography-mass Authors Xin Miao , Gilbert Koch , Shichen Shen , Xue Wang , Jun Li , Xiaomeng Shen , Jun Qu , Robert

The lung cancer cell line H1299-BRS3 was treated with MK-5046, an agonist of BRS3, for different durations Authors Miao Guo , Yan Zhang , Lehao Wu , Ye Sheng , Jiaqi Zhao , Zeyuan Wang , Huiyu Wang , Lu Zhang , Hua Xiao Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News

expression was significantly higher in the glioma tissues compared to the normal brain tissues, and was linked Functional annotation of GPR37 showed enrichment of ether lipid metabolism, fat digestion and absorption derived foam cell differentiation, negative regulation of T cell receptor signaling pathway, neuroactive ligand Authors Kairong Liang , Zhaoxiong Guo , Shizhen Zhang , Danmin Chen , Renheng Zou , Yuhao Weng , Chengxiang Peng , Zhichao Xu , Jingbai Zhang , Xiaorui Liu , Xiao Pang , Yunxiang Ji , Degui Liao , Miaoling Lai

The levels of GPCRRGs were examined in normal and OV cell lines using quantitative reverse-Etranscription Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled

Authors Xiaoyan Ding , Xiaoxia Li , Yanxia Jiang , Yujun Li , Hong Li , Lipeng Shang , Guilin Feng , Huhu Zhang , Ziyuan Xu , Lina Yang , Bing Li , Robert Chunhua Zhao Tags Autophagy , NSCLC , PKA-Hippo

secretion deficiencies and systemic insulin resistance (IR) in adipose tissue, skeletal muscle, and the liver Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Authors Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren

GPCRs in Oncology and Immunology GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid that GPR37 protects cancer cells from ferroptosis by upregulating SCD1 expression, thereby modulating lipid Mechanistic studies have shown that GPR37 modulates lipid metabolism in tumor cells by promoting SCD1 Authors Jiamin Zhou, Xigan He, Weixing Dai, Qingguo Li, Zhen Xiang, Yixiu Wang, Ti Zhang, Weiqi Xu, Lu Wang, Anrong Mao Tags Ferroptosis , GPR37 , Lipid metabolism , SCD1 , p38 Source Contribute to the GPCR

Sheng-Yue Wang , Hai Fang , Rui-Hong Zhang , Yue Zhu , Hong-Mei Yi , Xu-Feng Jiang , Jia-Yi Chen , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment

GPCR Podcast << Back to podcast list Dr. Nicolas Gilles About Dr. Nicolas Gilles "Dr. His strongest expertise lies in therapeutic target identification and all the steps from venom manipulations When the pharmacological properties of these new ligands are deemed exceptional, a lead optimization Nicolas Gilles on the web Google Scholar LinkedIn Dr. GPCR Thanks for listening to this podcast episode This short survey will help us understand your needs

Authors Hong Zeng , Li Cheng , De-Zhi Lu , Shuai Fan , Ke-Xin Wang , Li-Li Xu , Bin Cai , Mou-Wang Zhou

Authors Yanni Xi, Zhenya Min, Mianxue Liu, Xueqin Li, Zhao-Hua Yuan Tags P2Y12R , P2Y12R inhibitors ,

Monserrat Avila Zozaya on the web LinkedIn Antony Boucard Lab Dr. John Azietaku on the web LinkedIn Dr. GPCR About Ya-Tzu Li Ya-Tzu is a Master's student at the University of South Florida, utilizing large-scale Ya-Tzu Li on the web LinkedIn Dr. Cam Sinh Lu on the web LinkedIn Dr.

Authors Pengfei Yan, Xi Lin, Lijie Wu, Lu Xu, Fei Li, Junlin Liu, Fei Xu Source Contribute to the GPCR

GPCR Podcast << Back to podcast list Dr. Robert J. His legacy lies in the numerous discoveries he and his team made in the GPCR field and in all those who GPCR Ecosystem Thanks for listening to this podcast episode This short survey will help us understand Listen and subscribe to where you get your podcasts. << Previous Podcast Episode Next Podcast Episode

GPCR programs including the: Summit Virtual Cafe Listening to podcast episodes before these are released with your target audience Access to all member perks for your entire team Add your product and service listings Monserrat Avila Zozaya Get in touch Scientific Associate Ya-Tzu Li Get in touch Scientific Associate

Authors Pedram Shafiei-Jahani, Shi Yan, Mohammad H Kazemi, Xin Li, Amitis Akbari, Kei Sakano, Yoshihiro

Authors Kavita Rawat , Anita Tewari , Xin Li , Arlind B Mara , William T King , Sophie L Gibbings , Chinaza

Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune The Rottapel Lab Ontario Institute for Cancer Research University of Toronto Pubmed Google Scholar LinkedIn

tyramine, primarily produced by Enterococcus via tyrosine decarboxylase (tyrDC), serves as a microbial ligand Our findings highlight a microbial ligand-GPCR pair in ISCs, revealing a causal link between microbial Authors Chaoliang Li , Panrui Zhang , Yadong Xie , Shishan Wang , Meng Guo , Xiaowei Wei , Kaiguang Zhang

Abhishek Kumar Singh Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Formation in Li-Fraumeni Scholar X (Twitter) Investigating The Role of ADGRB3 Loss of Expression in Brain Tumor Formation in Li-Fraumeni Syndrome Alex Torrelli-Diljohn Abstract "Li-Fraumeni syndrome (LFS) is a rare cancer predisposition Authors & Affiliations "Vukadin L, Park B, Mohamed M, Li H, Elkholy A, Torrelli-Diljohn A, Kim JH, Jeong He is interested in working on Li-Fraumeni syndrome and helping patients afflicted with this condition

This work focussed on exploring the functions and mechanism of circFKBP5 in DPSC dysfunction evoked by lipopolysaccharide Authors Cuiwei Liang , Wenmiao Li , Qian Huang , Qitao Wen .

Authors Peng Kong , Xu Wang , Ya-Kun Gao , Dan-Dan Zhang , Xiao-Fu Huang , Yu Song , Wen-Di Zhang , Rui-Juan Guo , Han Li , Mei Han Tags Breast cancer , Regulator of G protein signaling 5 , Vascular remodeling

It was found that significantly aggravated psoriasis-like lesion in GPR97-/- mice. investigations indicated that beclomethasone dipropionate (BDP), an agonist of GPR97, attenuated the psoriasis-like Authors Yaoxin Gao, Weirong Zhan, Dandan Guo, Haizhen Lin, Muhammad Asad Farooq, Chenxu Jin, Li Zhang

Authors Kangjie Shen , Qiangcheng Wang , Lu Wang , Yang Yang , Min Ren , Yanlin Li , Zixu Gao , Shaoluan

of the majority of marketed drugs, the poor pharmacokinetics and physicochemical properties of GPCR ligands greatly limit their clinical applicability. Nanotechnology, as versatile techniques, can encapsulate GPCR ligands to assemble synthetic nano-GPCRs Moreover, endosomal delivery of GPCR ligands by nanoparticles can precisely initiate sustained endosomal Authors Yuhong Jiang , Yuke Li , Xiujuan Fu , Yue Wu , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun

epidemic diarrhea virus (PEDV) infection in African green monkey kidney epithelial cells (Vero) and Lilly Authors Xuyang Guo , Yingtong Feng , Xiaojing Zhao , Shuang Qiao , Zhiqian Ma , Zhiwei Li , Haixue Zheng , Shuqi Xiao .

Back to schedule Trainee Symposium II Date & Time Thursday, November 2nd / 3:00 PM - 4:00 PM Title: Linking My primary research focus lies in gaining deeper insights into the structural mechanisms governing G protein engineering, receptor pharmacology, and structural biology to study how different types of ligands