September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R activation in gut IELs to modulation of microbiota

2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune system to fight This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion

on ultrahigh-throughput technologies that biomine drug-like molecules from natural sources, such as microbiota

Immunology G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain Recent studies have demonstrated that small-molecules from gut microbiota act as ligands for specific and metabolite cataloging with mechanistic studies for an improved understanding of gut microbiota-immune-brain Authors Gajender Aleti , Emily A Troyer , Suzi Hong Tags G protein-coupled receptors , Gut microbiota , Human-microbiota interactions , Immune system , Inflammation , Metabolites Source Contribute to the

colitis Published date May 21, 2024 Abstract "Inflammatory bowel disease (IBD) is characterized by dysbiosis of the gut microbiota and dysfunction of intestinal stem cells (ISCs).

I am now working at the Cleveland Clinic in Ohio, USA, studying the gut microbiome and its impact on