September 2022 Divergent roles for the gut intraepithelial lymphocyte GLP-1R in control of metabolism, microbiota Instead, the gut IEL GLP-1R is essential for the full effects of GLP-1RAs on gut microbiota. cell-gut IEL GLP-1R axis, revealing mechanisms linking GLP-1R activation in gut IELs to modulation of microbiota

2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection "Healthy skin maintains a diverse microbiome and a potent immune system to fight This signaling axis was required for effective neutrophil-mediated skin immunity and microbiome homeostasis Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion

on ultrahigh-throughput technologies that biomine drug-like molecules from natural sources, such as microbiota

However, only a small fraction of these metabolites has been identified from the human microbiota thus

Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

microenvironment High Metabolite Concentrations in Portal Venous Blood as a Possible Mechanism for Microbiota

drug discovery via multitask learning GPCRs in Cardiology, Endocrinology, and Taste The Role of Gut Microbiota

Recent studies revealed butyrate and secondary bile acids, produced by the intestinal microbiome, potentiate We now aim to determine the molecular mechanism by which this functional microbiome output regulates

mice GPCRs in Oncology and Immunology A disturbed metabolite-GPCR axis is associated with microbial dysbiosis

immunodeficiency G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain