Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment of the most novel advances concerning the role of neurotransmitters in the normal neural and the GBM microenvironments

August 2022 "The common mechanisms by which members of the G protein-coupled receptor (GPCR) family respond to neurotransmitters in the brain have been well studied. However, it is becoming increasingly clear that GPCRs show great diversity in their intracellular location, interacting partners and effectors, and signaling consequences. Here we will discuss recent studies on the diversity of location, effectors, and signaling of GPCRs, and how these could interact to generate specific spatiotemporal patterns of GPCR signaling in cells." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent GPCR ligands "G-protein coupled receptors (GPCRs) have been largely targeted in a wide range of diseases, but few therapies have been directed against GPCRs in the field of cancer, partly because of the lack of effective target identification strategies. Here, using colorectal cancer (CRC) as a model, we explored the gene expression of a panel of GPCRs in tumor and stromal cells, identifying specific gene sets defining each cellular compartment. We selected the adenosine receptor 2B (A2BAR), specifically expressed in cancer cell lines compared with stromal cells, to explore the use of fluorescent ligands that can be used for target visualization. Fluorescent probes allowed semi-quantitative receptor mapping in living cells and validated the specific expression of A2BAR in CRC cell lines. As well, fluorescent ligands were effective at monitoring real-time A2BAR receptor labeling using live-imaging modalities, and displayed high efficiency when used to label complex 3D cellular systems such as tumor spheroids. Finally, we validated A2BAR as a potential pharmacological tool in CRC, using selective antagonists, finding a reduction in tumor cell proliferation. This proof-of-concept study suggests the use of fluorescent ligands for GPCR characterization through imaging, and as possible new tools used for target validation in drug screening methodologies." Read more at the source #DrGPCR #GPCR #IndustryNews

2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment " Background: Inflammatory microenvironment promotes odontoblastic differentiation in human dental pulp we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the inflammatory microenvironment

As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment show that through proper calibration, the model captures the macrophage heterogeneity in the tumor microenvironment

metastasis, and drug resistance and inflammation, all of which are influenced by the cellular and molecular microenvironment recently, gene editing techniques, have been tested to reduce the malignancy and generate a harmful microenvironment

high sensibility and specificity, T cells need to integrate different stimuli from the surrounding microenvironment

interactions among neuropeptides, receptor isoform-specific signaling events, and the inflammatory microenvironment

Insights into GPCR Function Synergistic and Competitive Lipid Interactions in the Serotonin 1A Receptor Microenvironment

living cells GPCRs in Oncology and Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment

Grants Under Nasdaq Listing Rule 5635(c)(4) GPCR signaling contributes to immune characteristics of the microenvironment

survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment

Assays GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment

mucronatus GPCRs in Oncology and Immunology GPCR signaling contributes to immune characteristics of microenvironment

Palmitoylation of the Glucagon-like Peptide-1 Receptor Modulates Cholesterol Interactions at the Receptor-Lipid Microenvironment

chemokine system to provide growth and survival signals, establish and maintain an immunosuppressive tumor microenvironment

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment

GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment.

scavenging of canonical chemokine receptors Clearing circulating chemokines and chemokines from tissue microenvironments