GPCR News < GPCRs in Oncology and Immunology GPCR signaling contributes to immune characteristics of microenvironment Single-cell transcriptome further delineated the tumor microenvironment as immune-inflamed, -deficient chemokine receptor-1 (CCR1) on malignant and immunosuppressive cells modulated virus-cancer interaction on microenvironment , Li Wang , Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment

< GPCR News < GPCRs in Oncology and Immunology Metabolic crosstalk: Extracellular ATP and the tumor microenvironment In the tumor microenvironment (TME), purinergic receptors such as ATP-gated ion channels P2X1-5 and G ) , Immunosuppression , Purinergic receptors , Purinergic signaling , Therapeutic potential , Tumor microenvironment

News < GPCRs in Oncology and Immunology RGS5 maintaining vascular homeostasis is altered by the tumor microenvironment Conclusions: These findings suggest that tumor microenvironment shifts the function of RGS5 from anti-inflammation

Aditya is interested in understanding the role of the membrane microenvironment in the subcellular organization pharmacology, subcellular trafficking, and membrane biology to better understand how the dynamic receptor microenvironment

GPR68-ATF4 signaling is a novel prosurvival pathway in glioblastoma activated by acidic extracellular microenvironment A defining hallmark of GBM is a highly acidic tumor microenvironment, which is thought to activate pro-tumorigenic However, the role of tumor microenvironment acidification in GPR68 activation has not been assessed in Results: We used a pHLourin2 probe to demonstrate how glioblastoma cells acidify their microenvironment

GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment In melanoma as well as in other cancers, acidification of the tumor microenvironment (= TME, inverse

platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis, and affect the tumor immune microenvironment , Mianxue Liu, Xueqin Li, Zhao-Hua Yuan Tags P2Y12R , P2Y12R inhibitors , Platelets , Tumor , Tumor microenvironment

tumor as well as immigration of tumor infiltrating immune cells that culminate in a tumor unique immune microenvironment activation influence the signaling machinery that drive cellular movement into and out of the tumor microenvironment

survival and immunotherapy response by the combined classifier of G protein-coupled receptors and tumor microenvironment Jianying Gu Tags G protein-coupled receptors , Immunotherapy , Melanoma , Multi-omics , Pan-cancer , Tumor microenvironment

Bin Yu, Mei Ma Tags GPCRs , cancer immune checkpoints , cancer immunotherapy , immune cells , tumor microenvironment

KLKs in this neoplasm are modulated by the secretome of the different cell types present in the tumor microenvironment

polyadenylation as a targetable driver of pancreatic cancer, and 2) dysregulation of the pancreatic tumor microenvironment discussion about their research on GPCRs, specifically focusing on GPR68 and its role in the tumor microenvironment team's current focus on alprazolam, an anti-anxiety medication that has unexpected effects in the tumor microenvironment

Pedersen Tags EPHA7 , Extracellular matrix , HCAR1 , Metabolite GPCR , Notch , PCDH7 , Spheroid , Tumor microenvironment

Within this dataset, we observed the association in the tumor microenvironment between the gene expression

expressed in renal AICs and ECs, and therefore are activated by distinct mechanisms unique to the cellular microenvironment