Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon heterotrimeric G proteins, which, in turn, activate signaling pathways that ultimately lead to cell migration CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging may allow cells to continuously migrate by remaining responsive to chemokines (S. D’Amico et. al 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to

August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular binding site and the Gαi interface attenuate G protein signaling and abolish oxysterol-mediated cell migration

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation Although less characterized, canonical CKRs have also been shown to not only directly regulate migration CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the it may interfere with other chemokine receptors which share the ligands and ultimately affect cell migration

< GPCR News < GPCRs in Oncology and Immunology GPR4 in the pH-dependent migration of melanoma cells in In this study, we investigated the pH-dependent migration of GPR4 wildtype/overexpressing SK-Mel-28 cells Migration of GPR4 overexpressing SK-Mel-28 cells was enhanced in a range of pH 6.5 - pH 7.5 as compared to controls in the impedance-based electrical wounding and migration assay. In Boyden chamber experiments, GPR4 overexpression only increased migration at pH 7.5 in a Matrigel-free

Oncology and Immunology CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration Published date September 1, 2023 Abstract "Immune responses rely on the rapid and coordinated migration Whereas it is well established that single-cell migration is often guided by gradients of chemokines receptor (GPCR) CCR7, we demonstrate that in addition to its role as the sensory receptor that steers migration This mechanism drives complex collective migration patterns, enabling DCs to create or sharpen chemotactic

< GPCR News < GPCRs in Oncology and Immunology TIPE proteins control directed migration of human T cells Published date November 11, 2023 Abstract "Tissue infiltration by circulating leukocytes via directed migration like (TIPE or TNFAIP8L) family of proteins are newly described pilot proteins that control directed migration demonstrated here that two human TIPE family members, TNFAIP8 and TIPE2 were essential for directed migration paradigm for how human T cells integrate GPCR and phospholipid signaling pathways to control directed migration