Canonical chemokine receptors – scavenging “decoys” Chemokine receptors coordinate cell migration upon heterotrimeric G proteins, which, in turn, activate signaling pathways that ultimately lead to cell migration CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging may allow cells to continuously migrate by remaining responsive to chemokines (S. D’Amico et. al 2000), becoming incapable of promoting cell migration, a phenomenon which is likely to

August 2022 "Oxysterols induce the migration of B-lymphocytes and dendritic cells to interfollicular binding site and the Gαi interface attenuate G protein signaling and abolish oxysterol-mediated cell migration

The immune system depends on chemokines to direct cell migration during immune surveillance and inflammation Although less characterized, canonical CKRs have also been shown to not only directly regulate migration CCR2 is an example of a dual-function receptor that directly regulates both cell migration and scavenging Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the it may interfere with other chemokine receptors which share the ligands and ultimately affect cell migration

Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement in cell migration Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from

and GPR15L in blood and synovial tissue samples from RA patients, as well as to perform a functional migration Migration assays were performed using PBMCs isolated from these individuals in response to the synthetic GPR15 and GPR15L are present in the synovial tissue of RA patients and GPR15L promotes migration of PBMCs

Oestrogen Receptor Expression in Breast Cancer Cells Does Not Correlate with Kisspeptin Signalling and Migration However, KP-10 stimulation induced migration of MDA-MB-231, but not BT-20 cells, in a calcium-dependent Overall, our data shows that, in TNBC, it is not universally true that kisspeptin/KISS1R stimulate migration

phospho-mimicking mutants and assays such as linear ion trap mass spectrometry, BRET, pull down, and transwell cell migration factor signaling might contribute to altered cellular behaviors in cancer, promoting uncontrolled cell migration

Methods Proliferation, migration and apoptosis assays were performed in ovarian cancer cells after

initiates several intracellular signaling pathways, regulating cell proliferation, survival, chemotaxis, migration

various biological processes, and both of them regulate cell proliferation and promote cell invasion and migration

during the lead optimization phase led to a compound with high biological potency in inhibiting cell migration

They have participated in various cellular processes such as cell proliferation, migration, apoptosis

Al 2017) and its activation promotes migration and angiogenesis (Kim S. et. al 2015). non-small-cell lung cancer OR2J3 activation induced apoptosis and inhibited cell proliferation and migration ) and the sandalore-activated receptor OR2AT4 shown to promote human keratinocyte proliferation and migration

They have participated in various cellular processes such as cell proliferation, migration, apoptosis

subtype 1 protein (TRPA1) signaling pathways, thereby regulating proliferation, inflammation, adhesion, migration

proliferation and apoptosis were evaluated using Cell Counting Kit-8 and colon formation, and cell migration

Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration High expression of GPR50 promotes the proliferation, migration and autophagy of hepatocellular carcinoma

Signaling GPCR screening reveals that the metabolite receptor HCAR3 regulates epithelial proliferation, migration on signaling pathways GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration

It effectively attenuates PAR2&4-Akt/PKB associations; PAR4 instigated Matrigel invasion and migration

malignant properties of breast cancer cells, such as inhibition of cell proliferation, colony formation, migration

histatin 1 (Hst1) exhibits a series of cell-activating properties, such as promoting cell spreading, migration

Therefore, we reviewed the ability of MSCs to migrate and home into the CNS of MS patients via expression

GPCR Activation and Signaling The dual-function chemokine receptor CCR2 drives migration and chemokine activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration

As GTP stabilizes and migrates towards the P loop, it causes the TCAT motif to shift, a key movement

ciliary regulation of hedgehog pathway repression in tissue morphogenesis TIPE proteins control directed migration

within the cell, is a crucial determinant of cellular responses such as proliferation, differentiation, migration

Oncology and Immunology LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration

ERK1/2 signaling CCR7 acts as both a sensor and a sink for CCL19 to coordinate collective leukocyte migration