October 2022 Increased Anxiety-like Behaviors in Adgra1-/- Male But Not Female Mice are Attributable We found that Adgra1-/- male but not female mice exhibited elevated anxiety levels in the open field, mice. Finally, we found that PI3K/AKT/GSK-3β and MEK/ERK in amygdalae of Adgra1-deficient male mice were aberrantly activated when compared to wt male mice.

This week's highlight includes congrats to: Miles Thompson , Alexander Hauser , Caroline Gorvin ,   et

Miles Thompson, Alexander Hauser, Caroline Gorvin et al. for their research on GPCR gene variants and

This week's highlight includes congrats to: Miles Thompson ,   Alexander Hauser ,   Caroline Gorvin ,

September 2022 Angiotensin-(1-7) improves cognitive function and reduces inflammation in mice following mild traumatic brain injury "Traumatic brain injury (TBI) is a leading cause of disability in the US study examined the therapeutic effect of Ang-(1-7) on secondary injury observed in a murine model of mild

September 2022 "The G-protein-coupled bile acid receptor, Gpbar1 or TGR5, is characterized as a membrane receptor specifically activated by bile acids.

The present study aims to investigate the possible role of FSH excess in male bone health, by comparing

The resulting homozygous hPTH1R-KI (humanized) mice were healthy over at least 10 generations and showed The initial evaluation of these mice and their potential utility for predicting behavior of PTH analogues

involves alveolar differentiation of mammary epithelial cells (MECs), which is essential for breast milk assessing changes in cellular viability, lipid accumulation, and gene and protein expression of major milk We hypothesized that THC and CBD will negatively impact the synthesis of milk proteins and lipids, as Relative to control, 10μM THC and 10μM CBD reduced mRNA levels of milk proteins (CSN2 and WAP) , lipid

mice. and female mice. DOI elicited more HTR in female as compared to male C57BL/6J mice, a sex-specific exacerbated behavior C57BL/6J mice. C57BL/6J mice.

impact delta and kappa opioid receptor-mediated synaptic depression in dorsolateral striatum of adult male mice Methods & Updates in GPCR Research RNA therapeutics in targeting G protein-coupled receptors: Recent

bivalent ligand enhances cellular signaling GPCR Binders, Drugs, and more Selenomethionine Promotes Milk Gi-GPCR signaling corrects compulsive-like grooming and anxiety-related behaviors in Sapap3 knockout mice

cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice retinal GPR3 expression and its possible involvement in axonal regeneration after retinal injury in mice Surprisingly, RGCs in GPR3 knockout mice were vulnerable to neural death during aging without affecting Evaluation of the effect of GPR3 on axonal regeneration using GPR3 knockout mice revealed that GPR3 in expression in RGCs helps maintain neuronal survival and accelerates axonal regeneration after ONC in mice

However, Gpr3-deficient mice display several adverse phenotypes, including elevated anxiety-like behavior In contrast to Gpr3-deficient mice, G protein-biased GPR3 mice do not display elevated anxiety levels suggest a protective glial response that may limit amyloid plaque development in G protein-biased GPR3 AD mice

of C265 augments β2AR protein kinase A signaling, enables β2AR nitric oxide (NO) signaling, renders mice resistant to bronchoconstriction, and protects mice from allergen-induced asthma."

Taking advantage of a striking deficit of both NPS receptor (NPSR1) and NPS precursor knockout mice in we demonstrate that intra-PVT injections of NPS can rescue the phenotype in NPS precursor knockout mice salience of otherwise low-intensity stimuli, while intra-PVT injections of NPSR1 antagonist in wild type mice

tissues of active ulcerative colitis (UC) patients and dextran sulfate sodium (DSS)-induced colitis mice GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients and the mice Consistently, GPR84-/- mice are resistant to the development of colitis induced by DSS.

uniquely rod phototransduction, we generated transgenic rods expressing Gγ1, Gγc, or Gγ11 in Gγ1-deficient mice However, Gαt1 translocation in Gγ11 transgenic mice occurred at significantly dimmer background light recordings revealed gradual response recovery in moderate background illumination in Gγ11 transgenic mice

Recent studies revealed butyrate and secondary bile acids, produced by the intestinal microbiome, potentiate RNA sequencing of intestinal epithelial cells responding to butyrate and secondary bile acids in combination

Methods: To address this question, we studied mice that express a Gs-coupled designer G protein-coupled Results: Acute stimulation of GsD signaling in SKM impaired glucose tolerance in lean and obese mice Clenbuterol injection improved glucose tolerance by increasing insulin secretion in lean mice.

Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration

Azodopa increases the overall neural activity in the cortex of anesthetized mice and displays illumination-dependent

Experimental approach: We used a series of behavioural assays to evaluate the acute responses of mice

In a LPS-induced lung inflammation model in mice, ACT-660602 led to significantly reduced recruitment

mouse expressing a non-cleavable GPR116 mutant phenocopies the pulmonary phenotype of GPR116 knock-out mice

Their research reveals how VU0486846 reduces neurogliosis in female Alzheimer's mice. Dr. receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice

GPCR Activation and Signaling Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility Cannabinoid tolerance in S426A/S430A x beta-arrestin 2 knock-out double mutant mice.

Finally, inhibition of Gq-GPCR coupling in mice enhanced the antinociceptive effects of morphine.