We previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. signaling broadly, induced partial resorption of the trabecular bone in the femurs of ColI(2.3)+/Rs1+ mice Notably, LGK974 caused significant bone loss in control mice.

Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer

neurotransmission Nicole Perry-Hauser GPR110 modulates anxiety-like behaviors and memory function in mice GPCR GPR110 modulates anxiety-like behaviors and memory function in mice potentially through neuronal Anxiety and memory function were tested using both male and female mice at 5-6 month of age. compared to wildtype mice. The y-maze showed a significant sex by genotype interactions with GPR110 KO male mice having increased

Mike then joined the lab of Dr. Muthuswamy moved to the University of Toronto, Mike joined the laboratory of Dr. Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its Career Trajectory and Faculty Position Yamina and Mike discussed Mike's career trajectory and his decision Towards the end, Yamina asked about job opportunities in Mike's lab, to which Mike responded that potential

Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell Gpr141 -/- mice showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells the experimental autoimmune encephalomyelitis-induced spinal cord compared with littermate control mice high amounts of interferon-γ, interleukin-17A, and interleukin-6 compared with those from wild-type mice Moreover, CD11c+ dendritic cells (DCs) purified from Gpr141 -/- mice increased cytokine production of

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GPR97 conditional depletion on dendritic cell (DC-cKO), and keratin 14-conditional knockout (K14-cKO) mice It was found that significantly aggravated psoriasis-like lesion in GPR97-/- mice. keratinocytes as well as accumulation of DCs and Th17 cells were detected in imiquimod (IMQ)-induced GPR97-/- mice

for heterodimer and show that the Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant in mice activity using cellular assays and Cxcr2 density in blood and recruited neutrophils in heterodimer-treated mice

Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing These mice can then be used to test dietary regimens, drugs, and adenoviral gene therapies for their

learn more about how Kari studies GPCRs in basal ganglia circuits following chronic alcohol exposure in mice

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels

vivo (measures of physiological and pathological cardiometabolic function in unconscious and conscious mice

Michael Lemieux ''My name is Michael (Mike) Lemieux and I am a Connecticut native.

GPR50 expression was observed to be significantly increased in the adipose tissue of obese T2DM mice,

In in vivo set-up, weekly intraperitoneal administration of Peptidase M84 in syngeneic mice significantly

tyrDC-deficient Enterococcus faecalis strain and intestinal epithelial cell-specific Adra2a knockout mice

Altered morphology and reduced numbers of astrocytes in the hippocampus of Adgrv1-deficent mice. intratumoral administration of the ADC in patient-derived GBM xenografts in the brain of immunodeficient mice resulted in significant reduction of tumor growth and prolongation of survival of host mice.

We also developed transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8

Attendees will be provided with Prism files, Excel templates and simulators, and the PowerPoints of the

formation by PDAC cells and suppressed the growth of Mia PaCa-2 cells xenografted into the flank of nude mice

germline Tp53 deletion) with a second floxed allele under the control of Nestin-Cre was crossed to Bai3-/- mice Immunoblots on wild-type and Adgrb1 exon 2-deleted mice, reverse transcription PCR and promoter-luciferase We performed single-nucleus RNA sequencing on male and female kidneys. snRNAseq revealed abundant, cell-specific

prostatic hyperplasia (BPH) are inflammations of the prostate gland, which surrounds the urethra in males Database-driven data mining and networking were utilized to establish a general correlation between Jinqiancao

the optimization of longitudinal intravenous self-administration paradigms for genetically modified mice