I received my PhD in Biology at Arizona State University, where I worked in the lab of Miles Orchinik

schedule A positive Allosteric Modulator of M1 Acetylcholine Receptors Improves Cognitive Deficits in Male and Female Alzheimer’s Mice Date & Time Friday, November 3rd / 1:55 PM About Khaled Abdelrahman Dr.

Ceddia 1, *, Zack Zurawski 2,3,*, Analisa Thompson Gray 2, Feyisayo Adegboye 2, Ainsley McDonald-Boyer

Oncology and Immunology A GPCR checkpoint drives CD8+ T cell dysfunction and immunotherapy failure in mice

We previously showed that ColI(2.3)+/Rs1+ mice, in which Gs-GPCR signaling was hyper-activated in osteoblastic Single-cell RNA sequencing on long-bone stromal cells of 9-wk-old male ColI(2.3)+/Rs1+ mice and littermate controls showed that fibroblastic stromal cells in ColI(2.3)+/Rs1+ mice were expanded. signaling broadly, induced partial resorption of the trabecular bone in the femurs of ColI(2.3)+/Rs1+ mice Notably, LGK974 caused significant bone loss in control mice.

Genetic Deletion of Atypical VGLUT3 Rescues Huntington’s Disease Phenotype and Neurodegeneration in zQ175 Mice

Con mice, and developed normally. can concentrate urine as effectively as control mice. Anxiety and memory function were tested using both male and female mice at 5-6 month of age. compared to wildtype mice. The y-maze showed a significant sex by genotype interactions with GPR110 KO male mice having increased

Mike then joined the lab of Dr. Muthuswamy moved to the University of Toronto, Mike joined the laboratory of Dr. Mike's Research on Cell Polarity and GPCRs in Cancer Mike shared his research on cell polarity and its Career Trajectory and Faculty Position Yamina and Mike discussed Mike's career trajectory and his decision Towards the end, Yamina asked about job opportunities in Mike's lab, to which Mike responded that potential

protein 6 alleviates acute lung injury by inhibiting inflammation and promoting cell self-renewal in mice

(OGR1) deficiency exacerbates crystal deposition and kidney injury in oxalate nephropathy in female mice investigated their role in crystalline nephropathy by increasing the oxalate intake of GPR4 KO and OGR1 KO mice While GPR4 deficiency did not show major alterations in disease progression, OGR1 KO mice had higher When lowering the severity of the kidney injury, OGR1 KO mice were more prone to develop crystalline In this setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production

Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell Gpr141 -/- mice showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells the experimental autoimmune encephalomyelitis-induced spinal cord compared with littermate control mice high amounts of interferon-γ, interleukin-17A, and interleukin-6 compared with those from wild-type mice Moreover, CD11c+ dendritic cells (DCs) purified from Gpr141 -/- mice increased cytokine production of

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with an N-terminal D-lysine, impairs growth of patient-derived xenografts of colorectal carcinoma in mice studied the capacity of LP2 to inhibit the growth of patient-derived xenografts of colorectal cancer in mice injected dose as low as 0.2 µg/kg/day inhibited patient-derived xenografts of colorectal carcinoma in mice

Candidate expression was evaluated in mice with UUO or diabetes or injected with adriamycin or folic Intervention studies were conducted in mice with diabetes or UUO. Tcf21+ α-smooth muscle actin (α-SMA)+ interstitial cells accumulated in the kidneys of mice with UUO or folic acid, whereas renin angiotensin system blockade attenuated increases in Tcf21 in diabetic mice the adenosine receptor antagonist, caffeine decreased Tcf21 upregulation and kidney fibrosis in UUO mice

Peritoneal macrophages obtained from naïve MacGpr101KO mice displayed a marked shift in the expression Gpr101 on macrophages disrupted host pro-resolving responses to zymosan challenge with MacGpr101KO mice significantly higher neutrophil numbers and a delay in the resolution interval when compared with control mice linked with a marked dysregulation in peritoneal lipid mediator concentrations in Gpr101 deficient mice

Methods: For in vivo studies, GPR110 wild type (WT) and knockout (KO) mice at 10-12 weeks of age were For in vitro studies, microglia and peritoneal macrophages were isolated from adult WT mice and treated expression in the brain was significantly higher after ethanol pretreatment in both WT and GPR110KO mice decreased the mRNA and/or protein expression of these cytokines and Iba-1 in the WT but not in GPR110KO mice upregulated by LPS was further elevated with prior exposure to ethanol, especially in the brains of GPR110KO mice

Gnaqfl/fl;Gna11-/-) and inducible (Pdgfrb-Cre/ERT2+/-;Gnaqfl/fl;Gna11-/-) mesenchymal Gαq/11 deleted mice Mice with constitutive Gαq/11 gene deletion exhibited abnormal alveolar development, with suppressed Tamoxifen-induced mesenchymal Gαq/11 gene deletion in adult mice resulted in emphysema associated with

GPR97 conditional depletion on dendritic cell (DC-cKO), and keratin 14-conditional knockout (K14-cKO) mice It was found that significantly aggravated psoriasis-like lesion in GPR97-/- mice. keratinocytes as well as accumulation of DCs and Th17 cells were detected in imiquimod (IMQ)-induced GPR97-/- mice

for heterodimer and show that the Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant in mice activity using cellular assays and Cxcr2 density in blood and recruited neutrophils in heterodimer-treated mice

2005 by studying the suitability of nanoparticles as porters of DNA vaccination against allergens in mice hyperparathyroidism and their impact on body calcium homeostasis and bone resorption in relevant transgenic mice

our understanding of the role of GPR110 signaling in kidney, we evaluated the urine albumin level in mice renal phenotype, we analyzed in parallel differential expression of kidney proteins in GPR110 KO and WT mice the albumin to creatinine ratio was significantly elevated in urine samples obtained from GPR110 KO mice proteins including VEGFA is associated with the abnormal renal phenotype of albumin urea in GPR110 KO mice

Our laboratory is working to help patients by developing genetically-modified mice that have disease-causing These mice can then be used to test dietary regimens, drugs, and adenoviral gene therapies for their

Constructing models of TAMs and LUAD mice, we find that A2aR highly expressed on LUAD cells promotes Functionally, blocking A2aR significantly suppresses TAMs infiltration and attenuates tumor burden in LUAD mice

the synergistic partner of BV were further investigated in vitro and in vivo using HH-cell xenograft mice The combined effects of chidamide and BV were demonstrated in a study of HH-cell xenograft mice; mean

learn more about how Kari studies GPCRs in basal ganglia circuits following chronic alcohol exposure in mice

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

Pluznick discovered that olfactory receptors in mice are also expressed in their kidneys and blood vessels

vivo (measures of physiological and pathological cardiometabolic function in unconscious and conscious mice