October 2022 Dual loss of regulator of G protein signaling 2 and 5 exacerbates ventricular myocyte Cardiac contractility, essential to maintaining proper cardiac output and circulation, is regulated by G protein-coupled Previously, the absence of regulator of G protein signaling (RGS) 2 and 5, separately, was shown to cause G protein dysregulation, contributing to modest blood pressure elevation and exaggerated cardiac hypertrophic Whether RGS2 and 5 redundantly control G protein signaling to maintain cardiovascular homeostasis is

Biosensors for monitoring G protein-coupled receptors (GPCRs), the most drugged class of proteins in Their applications have continually expanded our understanding of this important protein class.

A role for BET proteins in regulating basal, dopamine-induced and cAMP/PKA-dependent transcription in One candidate effector of PKA-dependent transcriptional regulation is the BET protein Brd4. However, it is unknown whether BET proteins, or Brd4 specifically, are involved in transcriptional activation Here, we demonstrate that in adult rats, inhibition of BET proteins with the bromodomain inhibitor JQ1 Our findings identify the BET protein family, and Brd4 in particular, as novel regulators of basal and

alpha 1/2 , Interleukin-31 receptor , Interleukin-31 receptor A , Interleukin-33 receptor , Interleukin-4 receptor alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors , JAKi , Janus kinase , MAPK , MCP-4 receptors , Mitogen-activated protein kinase , Monoclonal antibody , Monocyte chemoattractant protein -4 , MrgprA , MrgprA3 , MrgprCr11 , NGF , NMU , NP , Na(v) , Nasal polyps , Nerve growth factor , Neuromedin Transient receptor potential ankyrin 1 , Transient receptor potential cation channel subfamily M member 4

US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes Published date August 27, 2024 Abstract "Establishing a nonproductive, quiescent infection within monocytes We investigated the mechanisms through which HCMV establishes a quiescent infection in monocytes. US28 is a virally encoded G protein-coupled receptor (GPCR) that is essential for silent infections within We found that preformed US28 was rapidly delivered to monocytes by HCMV viral particles, whereas the

< GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor Published date April 29, 2024 Abstract "G protein-coupled messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b + Gr1+), monocytes Gpr141 -/- mice showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells Authors Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled