alpha 1/2 , Interleukin-31 receptor , Interleukin-31 receptor A , Interleukin-33 receptor , Interleukin-4 receptor alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors , JAKi , Janus kinase , MAPK , MCP-4 receptors , Mitogen-activated protein kinase , Monoclonal antibody , Monocyte chemoattractant protein -4 , MrgprA , MrgprA3 , MrgprCr11 , NGF , NMU , NP , Na(v) , Nasal polyps , Nerve growth factor , Neuromedin Transient receptor potential ankyrin 1 , Transient receptor potential cation channel subfamily M member 4

US28 by incoming HCMV particles rapidly attenuates Akt activity to suppress HCMV lytic replication in monocytes Published date August 27, 2024 Abstract "Establishing a nonproductive, quiescent infection within monocytes We investigated the mechanisms through which HCMV establishes a quiescent infection in monocytes. US28 is a virally encoded G protein-coupled receptor (GPCR) that is essential for silent infections within We found that preformed US28 was rapidly delivered to monocytes by HCMV viral particles, whereas the

< GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid cells functions as an inflammation suppressor Published date April 29, 2024 Abstract "G protein-coupled messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b + Gr1+), monocytes Gpr141 -/- mice showed increased CD11b + Gr1+ neutrophils, CD11b + Gr1- monocytes, CD11c+ dendritic cells Authors Atsuya Sawabe, Shogo Okazaki, Akira Nakamura, Ryo Goitsuka, Tomonori Kaifu Tags G protein–coupled

< GPCR News < GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells and platelets Published date September 27, 2024 Abstract "G-protein coupled receptors (GPCRs) method to profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic cells; monocytes , and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well

GPCR News < GPCRs in Oncology and Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant characterized the role for heterodimer and show that the Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant

and cancers Published date March 15, 2023 Abstract " C-X-C motif chemokine receptor 2 (CXCR2) is G protein-coupled Upregulation of CXCR2 is closely associated with the migration of neutrophils and monocytes. Hence, we provide an overview containing the discovery history, protein structure, signaling pathways

receptor 2 (BLT2) has been characterized as a low affinity receptor to several key eicosanoids and chemoattractants , Titli Nargis , Kierstin Webster , Sarah A Tersey , Ryan M Anderson , Raghavendra G Mirmira Tags G-protein

Oncology and Immunology Molecular docking and dynamics simulation studies uncover the host-pathogen protein-protein The P. vannamei-V. parahaemolyticus protein-protein interaction of Complex 1 (Ferritin-HrpE/YscL family type III secretion apparatus protein), Complex 2 (Protein kinase domain-containing protein-Chemotaxis CheY protein), and Complex 3 (GPCR-Chemotaxis CheY protein) was found to interact with -4319.76, -5271.39 , and -4725.57 of the docked score and the formation of intermolecular bonds at several interacting residues

News < GPCRs in Oncology and Immunology Small-molecule targeting of GPCR-independent noncanonical G-protein signaling in cancer Published date April 25, 2023 Abstract " Activation of heterotrimeric G-proteins (Gαβγ) by G-protein-coupled receptors (GPCRs) is a quintessential mechanism of cell signaling widely However, it has become evident that heterotrimeric G-proteins can also be activated via GPCR-independent Tags G protein , GPCR , cancer , drug discovery .

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates Regulator of G protein signaling protein 6 (RGS6), identified as a tumor suppressor gene, has received Methods: Congruously regulated G protein-coupled receptor (GPCR)-related genes and differentially expressed Results: A total of 110 congruously regulated genes (61 congruously upregulated and 49 congruously downregulated Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation , Regulator of G protein

Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling by acting as negative regulators of G proteins. of these mutations on protein function is uncertain. signaling (RGS) proteins.

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression Published date July 31, 2024 Abstract "G protein-coupled receptors (GPCRs) are Additionally, we focus on the roles of GPCRs in regulating immune checkpoint proteins involved in immune

< GPCR News < GPCRs in Oncology and Immunology Interplay between G protein-coupled receptors and nanotechnology Published date July 28, 2023 Abstract "G protein-coupled receptors (GPCRs), as the largest family of , Rujing Wang , Mengnan Zhao , Canquan Mao , Sanjun Shi Tags Drug delivery , Endosomal delivery , G protein-coupled

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis G protein signaling (RGS) protein family modulators play essential role within regulating downstream Our study focused on the expression patterns of RGS proteins in CRC, identifying Regulator of G protein We confirmed the elevated RGS16 protein level in CRC, and found that patients with RGS16-high tumors

GPCR News < GPCRs in Oncology and Immunology Pan-cancer functional analysis of somatic mutations in G protein-coupled receptors Published date December 1, 2022 Abstract G Protein-coupled receptors (GPCRs) are the most While the location of the mutations across the protein domains did not differ significantly in the two

< GPCR News < GPCRs in Oncology and Immunology Signaling by Neutrophil G Protein-Coupled Receptors that Neutrophils, which express many receptors that are members of the large family of G protein-coupled receptors molecular patterns such as the N-formylated peptides that are formed during bacterial and mitochondrial protein

< GPCR News < GPCRs in Oncology and Immunology Combinatorial depletions of G-protein coupled receptor cells identify pleiotropic and cell type-specific functions Published date November 1, 2022 Abstract G-protein They can be recruited to agonist-activated G-protein coupled receptors (GPCRs) and phosphorylate their Authors Katharina M Glaser, Teresa K Tarrant, Tim Lämmermann Tags B cells; G-protein coupled receptors

< GPCR News < GPCRs in Oncology and Immunology Gallein, G protein βγ subunits inhibitor, suppresses the carcinoma cells via inhibition of the c-Jun N-terminal kinase Published date November 13, 2024 Abstract "G protein-coupled receptor (GPCR) signaling regulates a wide range of pathophysiological cell functions via G protein human hepatocellular carcinoma (HCC) HuH7 cells through the activation of AKT, p38 mitogen-activated protein JNK without affecting the phosphorylation of epidermal growth factor receptor, AKT, p38 MAPK, target protein

< GPCR News < GPCRs in Oncology and Immunology Identification of a G-protein coupled receptor-related G protein-coupled receptors (GPCRs, the largest family of human cell surface receptors) are associated Authors Shaohan Ma, Ruyue Li, Guangqi Li, Meng Wei, Bowei Li, Yongmei Li, Chunfang Ha Tags G protein-coupled

Feyisayo Adegboye 2, Ainsley McDonald-Boyer 3, Fubiao Shi 1, Dianxin Liu 1, Jose Maldonado 5, Jiesi Feng 4, Yulong Li 4, Simon Alford 5, Julio E. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN 37232, USA 4 Her laboratory has been involved in studying G protein coupled signal transduction for many years and has made key discoveries in G protein structure and mechanisms of activation by GPCRs and activation

by G protein-coupled receptors (GPCRs). The structure was first snapshot of the agonist- and G protein-bound GPCR, providing valuable models for agonist-mediated activation of G proteins. We continue to utilize these data to better understand the basis for receptor-G protein specificity and changes in G protein structure.

unsuccessful, but led to the identification of GRK5 and continued focus on GRKs (particularly GRKs 4,5,6 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

unsuccessful, but led to the identification of GRK5 and continued focus on GRKs (particularly GRKs 4,5,6 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

unsuccessful, but led to the identification of GRK5 and continued focus on GRKs (particularly GRKs 4,5,6 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

unsuccessful, but led to the identification of GRK5 and continued focus on GRKs (particularly GRKs 4,5,6 For this, we have worked in three main areas: the regulation of G protein-coupled receptor signaling particularly by the G protein-coupled receptor kinase (GRK) – beta-arrestin system, the coordination of heterotrimeric G protein, small GTP-binding protein and protein kinase pathways by GIT/PIX scaffolding complexes during cellular signaling, and characterizing the role of protein S-nitrosylation as a signaling

In her postdoctoral period, she has participated in the identification and characterization of proteins that act at the level of G proteins and which are part of a multimolecular signaling complex (AGS, de “Activators of G-protein signaling). These results have been published in the journal Nature Communications (12 (1):4540, 2021) with the title Ribas has also described a new protective role of G protein-coupled receptor kinase 2 (GRK2), a known

chemerin is the endogenous ligand of the chemokine-like receptor 1 (CMKLR1), a member of the family of G protein-coupled This protein ligand plays an important role in obesity and inflammatory processes. Using receptor chimera of G protein-coupled receptor 1 (GPR1) and CMKLR1, we were able to identify the Tags double mutant cycle analysis , protein expression , protein-protein interaction , receptor binding

Results: Out of the total of 65 OSCC tissues, 41 tissues (63.1%) exhibited high expression for β2-AR protein. Percent positivity and relative density (mean ± SD) of protein were higher in the case group as compared to the control group (positivity 40.31 ± 3.01 vs. 20.46 ± 1.93, p < 0.001; density 2.77 ± 1.17 vs. 1.28 Conclusion: β2-AR protein level is identified as an independent significant prognostic factor in patients