October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent Def and Mrgpra2 mutant animals both exhibited skin dysbiosis, with reduced microbial diversity and expansion Defensins and Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil Activation of Mrgpra2 by defensin triggered neutrophil release of IL-1β and CXCL2 which are vital for This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis

Members of the Mas-related G protein coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue However, involvement of the human Mas-related G-protein coupled receptor D (MRGPRD) in the regulation By stimulating human MRGPRD-expressing HeLa cells with the agonist β-alanine, we observed a release of Additionally, we investigated the constitutive (ligand-independent) and basal activity of MRGPRD and

receptors , Mitogen-activated protein kinase , Monoclonal antibody , Monocyte chemoattractant protein-4 , MrgprA , MrgprA3 , MrgprCr11 , NGF , NMU , NP , Na(v) , Nasal polyps , Nerve growth factor , Neuromedin U ,