September 2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal cell-specific G-protein-coupled receptor (GPCR), known as Mas-related G protein-coupled receptor-B2 (MRGPRB2 However, the opening of ion channels mediated by MRGPRB2 activation remains unclear. The increases in [Ca2+]i and voltage-dependent current caused by MRGPRB2 activation were blocked by U73122 The voltage-dependent current induced by MRGPRB2 was inhibited by calcium-activated chlorine channel

October 2022 Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent We generated mutant mouse lines lacking the entire Defensin (Def) gene cluster in keratinocytes or Mrgpra2a Defensins and Mrgpra2 were critical for combating S. aureus infections and the formation of neutrophil Activation of Mrgpra2 by defensin triggered neutrophil release of IL-1β and CXCL2 which are vital for This study demonstrated the importance of epithelial-neutrophil signaling via the defensin-Mrgpra2 axis

Members of the Mas-related G protein coupled receptors (MRGPRs), a subfamily of GPCRs, are largely expressed Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue However, involvement of the human Mas-related G-protein coupled receptor D (MRGPRD) in the regulation By stimulating human MRGPRD-expressing HeLa cells with the agonist β-alanine, we observed a release of Additionally, we investigated the constitutive (ligand-independent) and basal activity of MRGPRD and

alpha , Interleukin-5 receptor alpha , JAK , JAK inhibitors , JAKi , Janus kinase , MAPK , MCP-4 , MRGPRX1 receptors , Mitogen-activated protein kinase , Monoclonal antibody , Monocyte chemoattractant protein-4 , MrgprA , MrgprA3 , MrgprCr11 , NGF , NMU , NP , Na(v) , Nasal polyps , Nerve growth factor , Neuromedin U ,