Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic Peng-Peng Xu , Sai-Juan Chen , Wei-Li Zhao Tags CCR1 , Epstein-Barr virus , Lymphoma , Microenvironment , Multi-omics

Yanwen Yang , Chuanyuan Wei , Jianying Gu Tags G protein-coupled receptors , Immunotherapy , Melanoma , Multi-omics

GPCR antibody drug discovery Abstract Developing monoclonal antibody drugs against GPCRs and other multi-pass Several case studies of GPCR and other multi-pass transmembrane targets are presented, including GPRC5D

Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

vast variety of critical biological processes and provide an ideal case study for quantitative, and multi‐scale

We subsequently created a ranking of high scoring GPCRs, using a multi-objective approach (Pareto Front

Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR.

subsequently incorporated into our previously-established cell cycle model, forming a comprehensive, multi-scale

review highlights the importance of designing and adaptation of next-generation strategies such as GPCR-omics

Several compounds showed multi-target properties.

< GPCR News < GPCRs in Oncology and Immunology The β2-adrenergic receptor associates with CXCR4 multimers We also found that β2AR associates with CXCR4 multimers in MDA-MB-231 and HCC4006 cells to a higher degree

Shi Yan, Mohammad H Kazemi, Xin Li, Amitis Akbari, Kei Sakano, Yoshihiro Sakano, Benjamin P Hurrell, Omid

aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain

angiogenesis inhibitor 1 (BAI1) belongs to the adhesion G-protein-coupled receptors, which exhibit large multi-domain