GPCR antibody drug discovery Abstract Developing monoclonal antibody drugs against GPCRs and other multi-pass Several case studies of GPCR and other multi-pass transmembrane targets are presented, including GPRC5D

Ilana’s research is multi-disciplinary and involves a close collaboration with proteomics experts at

vast variety of critical biological processes and provide an ideal case study for quantitative, and multi‐scale

We subsequently created a ranking of high scoring GPCRs, using a multi-objective approach (Pareto Front

Methods: We identified GPCRs expressed in primary CD4+CCR5+ T cells by multi-RT-qPCR.

Shi Yan, Mohammad H Kazemi, Xin Li, Amitis Akbari, Kei Sakano, Yoshihiro Sakano, Benjamin P Hurrell, Omid

aGPCRs) are key cell-adhesion molecules involved in numerous physiological functions. aGPCRs have large multi-domain