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GPCRs in Oncology and Immunology Comparison of infectious complications with BCMA-directed therapies in multiple myeloma Published date May 31, 2024 Abstract "B-cell-maturation-antigen (BCMA)-directed therapies are highly active for multiple myeloma, but infections are emerging as a major challenge.

< GPCR News < GPCRs in Oncology and Immunology The binding mechanism of an anti-multiple myeloma antibody Its high expression on the surface of multiple myeloma cells has rendered it an attractive target for GPCR but also hold the potential to advance drug development targeting GPRC5D for the treatment of multiple myeloma."

Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma Published date August 22, 2024 Abstract "Multiple myeloma (MM) is a complex hematological malignancy Authors Jihong Jeong, Junhyeon Park, Geun Young Mo, Jinwoo Shin, Yunje Cho Tags GPRC5D , Multiple myeloma

Oncology and Immunology Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma the astonishing outcomes after chimeric antigen receptor (CAR) T-cell therapy for relapsed refractory multiple myeloma (RRMM), most patients eventually relapse.

investigational autologous BCMA CAR T-cell products at the recommended phase 2 dose) for relapsed/refractory multiple myeloma between November 2016 and May 2022.

Cardiovascular Complications and Their Association With Short- and Long-Term Outcomes in Patients With Multiple Myeloma and Lymphoma Undergoing Chimeric Antigen Receptor T-Cell Therapy Read More November 26, 2024 More December 5, 2024 Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma

GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid High GPR141 messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell exacerbated disease conditions of experimental autoimmune encephalomyelitis, an autoimmune disease model for multiple 141 , autoimmune disease , dendritic cells , experimental autoimmune encephalomyelitis , monocytes , myeloid

Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid November 1, 2022 Abstract Blocked cellular differentiation is a critical pathologic hallmark of acute myeloid differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid this study demonstrated that activation of orphan GPR132 represents a potential strategy for inducing myeloid

The chemokine system is relatively unique in having multiple receptors and multiple ligands that display

state, while apo-ACKR3 shows little conformational preference and high transition probabilities among multiple Multiple active-like ACKR3 conformations are populated in response to agonists, compared to the single

< GPCR News < GPCRs in Oncology and Immunology Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia Published date June 14, 2024 Abstract " Purpose: The inherent genetic heterogeneity of acute myeloid

of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid leukemia

study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia Published date November 1, 2023 Abstract "PLK1 is overexpressed in acute myeloid leukemia (

creating an automated chimeric homology modeling pipeline for GPCRs and since have branched out to multiple

creating an automated chimeric homology modeling pipeline for GPCRs and since have branched out to multiple

been an undergraduate student member in the Rajagopal Lab since January 2021 and has contributed to multiple

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

Syndrome Alex Torrelli-Diljohn GPR124 Mediates Adhesion Of Leukemic Stem Cells To Their Niche And Leads To Myeloid at Birmingham LinkedIn GPR124 Mediates Adhesion Of Leukemic Stem Cells To Their Niche And Leads To Myeloid these studies highlight the possibility that tissue expression of single aGPCRs is likely comprised of multiple Detection of transcripts that do, and do not, contain multiple variable regions suggests expression of multiple mRNAs in specific cells.

He discovered multiple rare and loss-of-function variants of the MT2 melatonin receptors that are associated

chemoattractant Published date November 24, 2023 Abstract "Microbial infection is characterized by release of multiple

Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory

He currently holds multiple research grants from the Canadian Institutes of Health Research (CIHR) for

GPCR pharmacology through structure determination of the β1-adrenoceptor and adenosine A2A receptor in multiple

Caron currently holds multiple scientific advisory roles in academia, industry and the National Institutes

He has served on multiple panels and committees, including the ENDO Annual Meeting Steering Committee

This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple

Moreover, he is closely involved in multiple projects where he focuses on the generation of nanobodies

an acknowledged expert in drug discovery, particularly in the field of psychiatry, where he has led multiple