Immunology Structural Basis for the Recognition of GPRC5D by Talquetamab, a Bispecific Antibody for Multiple Myeloma Published date August 22, 2024 Abstract "Multiple myeloma (MM) is a complex hematological malignancy Authors Jihong Jeong, Junhyeon Park, Geun Young Mo, Jinwoo Shin, Yunje Cho Tags GPRC5D , Multiple myeloma

investigational autologous BCMA CAR T-cell products at the recommended phase 2 dose) for relapsed/refractory multiple myeloma between November 2016 and May 2022.

GPCR News < GPCRs in Oncology and Immunology The orphan G protein-coupled receptor 141 expressed in myeloid High GPR141 messenger RNA levels were expressed in myeloid-lineage cells, including neutrophils (CD11b Gpr141 -/- mice, which we independently generated, displayed almost no abnormalities in myeloid cell exacerbated disease conditions of experimental autoimmune encephalomyelitis, an autoimmune disease model for multiple 141 , autoimmune disease , dendritic cells , experimental autoimmune encephalomyelitis , monocytes , myeloid

The chemokine system is relatively unique in having multiple receptors and multiple ligands that display

of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia Published date July 1, 2024 Abstract "Imatinib (IM), a breakthrough in chronic myeloid leukemia

Syndrome Alex Torrelli-Diljohn GPR124 Mediates Adhesion Of Leukemic Stem Cells To Their Niche And Leads To Myeloid at Birmingham LinkedIn GPR124 Mediates Adhesion Of Leukemic Stem Cells To Their Niche And Leads To Myeloid these studies highlight the possibility that tissue expression of single aGPCRs is likely comprised of multiple Detection of transcripts that do, and do not, contain multiple variable regions suggests expression of multiple mRNAs in specific cells.

study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia Published date November 1, 2023 Abstract "PLK1 is overexpressed in acute myeloid leukemia (

The lab works with multiple models, including Caenorhabditis elegans, in vitro tissue culture, and mice

been an undergraduate student member in the Rajagopal Lab since January 2021 and has contributed to multiple

chemoattractant Published date November 24, 2023 Abstract "Microbial infection is characterized by release of multiple

He discovered multiple rare and loss-of-function variants of the MT2 melatonin receptors that are associated

GPCR pharmacology through structure determination of the β1-adrenoceptor and adenosine A2A receptor in multiple

He currently holds multiple research grants from the Canadian Institutes of Health Research (CIHR) for

This pathway is implicated in mechanisms related to many diseases, such as cancer, psoriasis, multiple

He has served on multiple panels and committees, including the ENDO Annual Meeting Steering Committee

Caron currently holds multiple scientific advisory roles in academia, industry and the National Institutes

an acknowledged expert in drug discovery, particularly in the field of psychiatry, where he has led multiple

He currently holds multiple research grants from the Canadian Institutes of Health Research (CIHR) for

Moreover, he is closely involved in multiple projects where he focuses on the generation of nanobodies

Considering the multiple functions of kinin receptors and KLKs, this review highlights their roles, even

mutated in almost all cases of uveal melanoma and use model-driven explorations to uncover and explore multiple

Caron currently holds multiple scientific advisory roles in academia, industry and the National Institutes

Dysregulation of prenylation contributes to multiple disorders, including cancers and vascular and neurodegenerative

Multiple Wnt ligands were up- or downregulated in different cellular populations, including in non-osteoblastic

With the little knowledge on these receptors available, there were multiple questions to tackle.

sorafenib improves event-free survival (EFS) when used with 7 + 3 in adults with newly-diagnosed acute myeloid

official rules for your Promotion must include a clear statement that anyone found to have created multiple Use of Multiple Accounts Do not create or use multiple accounts to evade our policies or bypass blocks

I also work on multiple other kinases in our laboratory implicated in various neurodevelopmental and