Until recently, itch pathophysiology was poorly understood and treatments were poorly effective in relieving itch. Current progress in our knowledge of the itch processing, the numerous mediators and receptors involved has led to a large variety of possible therapeutic pathways. Currently, inhibitors of IL-31, IL-4/13, NK1 receptors, opioids and cannabinoids, JAK, PDE4 or TRP are the main compounds involved in clinical trials. However, many new targets, such as Mas-related GPCRs and unexpected new pathways need to be also explored. Read full article

autophagy deficiency in myeloid cells "Background Eosinophilic inflammation is a hallmark of refractory chronic

March 2022 Inversago Pharma Announces Dosing of First Participant with Metabolic Syndrome in Phase 1B portfolio of CB1 inverse agonists, announced today the dosing of the first participant with metabolic syndrome pharmacokinetics and safety profile of Inversago’s lead molecule, INV-202, on a targeted population with metabolic syndrome

Characterization of a new WHIM syndrome mutant reveals mechanistic differences in regulation of the chemokine truncations, frame shifts and point mutations in the chemokine receptor CXCR4 have been identified in WHIM syndrome Here, we report on a new WHIM syndrome mutation that results in a frame shift within the codon for Ser339 S339fs5) and compare the properties of S339fs5 with wild type CXCR4 and a previously identified WHIM syndrome Taken together, these studies identify a new WHIM syndrome mutant, CXCR4-S339fs5, that promotes enhanced

August 2022 "The X-linked form of Kallmann syndrome (KS), characterized by hypogonadotropic hypogonadism

of β-arrestin2 alleviates apoptosis through GRP78-ATF6-CHOP signaling pathway in primary Sjögren's syndrome The etiology of primary Sjögren's syndrome (pSS) remains unknown, and there is no ideal drug for the In this study, we established an experimental Sjögren's syndrome (ESS) mouse model to elucidate the molecular

October 2022 "Systolic heart failure (HF) is a chronic clinical syndrome characterized by the reduction Chronic human HF is characterized by several important neurohormonal perturbations, emanating from both GPCR signaling and regulation, as they pertain to modulation of cardiac function in the context of chronic

utilized single particle tracking (SPT) to monitor diffusion of serotonin1A receptors under acute and chronic in the confined population of the receptor accompanied by a reduction in diffusion coefficient for chronic supported by our recent work and present observations that show polymerization of G-actin in response to chronic

utilized single particle tracking (SPT) to monitor diffusion of serotonin1A receptors under acute and chronic in the confined population of the receptor accompanied by a reduction in diffusion coefficient for chronic supported by our recent work and present observations that show polymerization of G-actin in response to chronic

Morphine is one of the most widely used and proven analgesic for the treatment of severe acute or chronic Complex Persistent Opioid Dependence-an Opioid-induced Chronic Pain Syndrome.

targeting PAR-1 G protein-coupled receptors related to autoimmunity in postural orthostatic tachycardia syndrome Entrepreneur Of The Year® 2024 Pacific Southwest Award Winner Monlunabant by Inversago Pharma for Metabolic Syndrome Trevena Announces Preclinical TRV045 Data Providing Insight Into Novel Mechanism of Analgesic Effect in Chronic

clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range of chronic

Finally, we briefly discuss the therapeutic targeting of vGPCRs as future treatment of acute and chronic

November 2021 " Chronic use of most opioids causes tolerance; the new compounds avoid this and other

exclusive rights to develop its own independent GABAB PAM program, have also been expanded to include chronic

Endocrinology and Pharmacology Laboratory team who are investigating new ways to tackle the disease-inducing chronic

mogamulizumab has also been approved in Japan and by the FDA for the treatment of mycosis fungoides or Sézary syndrome rigorous for this class, as the majority of potential therapeutic applications are situated in the area of chronic

Alzheimer's disease and multiple sclerosis, in the recovery from central nervous system injuries, in several chronic

In a recent work, we reported that chronic cholesterol depletion using statins leads to significant polymerization

inflammatory responses, offering potential therapeutic avenues for conditions such as autoimmune diseases and chronic

signaling and the AMPK and TOR pathways, and those that alter oxidative homeostasis and severe and/or chronic

context-dependent compared to the C5aR1, which has received enormous attention for its role in both acute and chronic

for their investigation on Modulation of contextual fear acquisition and extinction by acute and chronic signaling in murine brain tissue Modulation of contextual fear acquisition and extinction by acute and chronic

Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response

GPCR Activation and Signaling Targeting GRK2 and GRK5 for treating chronic degenerative diseases: Advances

mesenchymal stem cells in multiple sclerosis patients Multiple sclerosis (MS) is a specific type of chronic

GPCR Function Interplay of Cholesterol and Actin in Neurotransmitter GPCR Signaling: Insights from Chronic

Reports Second-Quarter 2023 Financial Results, Provides Corporate Updates, and Reports Emerging Data from Chronic