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fully understood, but the working hypothesis postulates that a combination of epithelial injury and myofibroblast , and that TGF-β1 then drives its own activation, creating a feed-forward mechanism that propagates myofibroblast In fibroblasts, OGR1 inhibits myofibroblast differentiation and does not contribute to inflammation.

pathways and stem cell maintenance such as by employing hedgehog and WNT, which promote fibroblast-to-myofibroblast

on 'G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts Signaling G Protein-Biased Agonists for Intracellular Angiotensin Receptors Promote Collagen Secretion in Myofibroblasts

< GPCR News < GPCRs in Oncology and Immunology GPR176 promotes fibroblast-to-myofibroblast transition characterized by excessive deposition of extracellular matrix proteins, particularly collagen, caused by myofibroblasts Among them, we focused on Gpr176 owing to its significant correlation with a myofibroblast marker α-smooth Consequently, Gpr176 acts in a profibrotic manner, and inhibiting its activity could potentially prevent myofibroblast Daisuke Koga, Ryo Miyashima, Hironobu Ishimaru, Kazuhito Tsuboi Tags Fibroblast , Fibrosis , Gpr176 , Myofibroblast

Mice with constitutive Gαq/11 gene deletion exhibited abnormal alveolar development, with suppressed myofibroblast