Notably, TNFα activation of NF-κB was totally impaired after GPR108 knockout. engaged with GPR108 and promoted its degradation, knockout of GPR108 remarkably blocked GA inhibition of NF-κB

G Protein-Coupled Receptor D Induces Release of the Inflammatory Cytokine IL-6 and Is Dependent on NF-κB pathway, which results in an IkB kinases (IKK)-mediated canonical activation of nuclear factor kappa-B (NF-κB

hypersensitivity implicate potential contributions of mitogen-activated protein kinase (MAPK) and nuclear factor κB (NF-κB). MAPKs (extracellular signal-regulated kinase [ERK], p38) and redox-sensitive transcription factors (NF-κB mechanistic insight into how GPR183 signaling in the spinal cord produces hypersensitivity through MAPK and NF-κB We found that 7α,25-OHC-induced allodynia is dependent on MAPK and NF-κB signaling pathways and results

immunofluorescence staining were used to further investigate the activation of nuclear factor-kappa B (NF-κB Furthermore, immunofluorescence staining showed that NF-κB p65 in the control group was mainly concentrated Moreover, GPRC5A played a role in inflammation regulation by interacting with NF-κB signaling pathway

Peptidase M84 induced PAR-1 overexpression along with activating its downstream signaling effectors NF-κB

LUAD cells promotes the secretion of chemokines and polarizing factors through activating PI3K/AKT/NF-κB