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199 items found for "Network pharmacology"

  • Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of...

    October 2022 Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment The network pharmacology method was used to constructe the "herb-component-target" network, and elucidated The "herb-component-target" network indicated that the ingredients of Girinimbin, Gomisin B and Asarone

  • Navigating the Signaling Network: RTK and GPCR Crosstalk Uncovered

    One fascinating aspect of the cellular signaling network is the crosstalk between G protein-coupled receptors

  • Platelets in the NETworks interweaving inflammation and thrombosis

    September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to control hemorrhage. Research over the past years has provided a substantial body of evidence demonstrating that platelets also participate in host innate immunity. The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with the ability to sense bacterial products in their environment. Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory signaling. Additionally, platelet interactions with neutrophils enhance neutrophil activation and are often crucial to induce a sufficient immune response. In particular, platelets can activate neutrophils to form neutrophil extracellular traps (NETs). This specific neutrophil effector function is characterized by neutrophils expelling chromatin fibres decorated with histones and antimicrobial proteins into the extracellular space where they serve to trap and kill pathogens. Until now, the mechanisms and signaling pathways between platelets and neutrophils inducing NET formation are still not fully characterized. NETs were also detected in thrombotic lesions in several disease backgrounds, pointing towards a role as an interface between neutrophils, platelets and thrombosis, also known as immunothrombosis. The negatively charged DNA within NETs provides a procoagulant surface, and in particular NET-derived proteins may directly activate platelets. In light of the current COVID-19 pandemic, the topic of immunothrombosis has become more relevant than ever, as a majority of COVID-19 patients display thrombi in the lung capillaries and other vascular beds. Furthermore, NETs can be found in the lung and other tissues and are associated with an increased mortality. Here, virus infiltration may lead to a cytokine storm that potently activates neutrophils and leads to massive neutrophil infiltration into the lung and NET formation. The resulting NETs presumably activate platelets and coagulation factors, further contributing to the subsequent emergence of microthrombi in pulmonary capillaries. In this review, we will discuss the interplay between platelets and NETs and the potential of this alliance to influence the course of inflammatory diseases. A better understanding of the underlying molecular mechanisms and the identification of treatment targets is of utmost importance to increase patients’ survival and improve the clinical outcome." Read more at the source #DrGPCR #GPCR #IndustryNews

  • Job Opportunity Spotlight #1: Principal Scientist, In Vitro Pharmacology

    As Chief Matchmaker, I recently had the pleasure of speaking with Beth Fleck, Director of In Vitro Pharmacology Beth is also the hiring manager for their open Principal Scientist, In Vitro Pharmacology role posted Top candidates will have a solid foundation in GPCR pharmacology as well as some experience in drug discovery

  • Pharmacological Properties and Function of PxOctβ3 Octopamine Receptor in Plutella xylostella (L.)

    This study demonstrated the pharmacological properties and functions of PxOctβ3 in P. xylostella, thus

  • Exploring pharmacological inhibition of G q/11 as an analgesic strategy

    The aim of this study was to test this hypothesis pharmacologically by using potent and selective Gq/

  • Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of...

    September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model of immunotherapy in triple-negative breast cancer "Quantitative systems pharmacology (QSP) modeling is

  • Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal Epith

    September 2022 Microbial Metabolites Orchestrate a Distinct Multi-Tiered Regulatory Network in the Intestinal These findings shed light on a sophisticated signaling network directed by intestinal microbial metabolites

  • Research Network on Signal Transduction (ERNEST) has established an Emergency Fund for Ukrainian ...

    The purpose of the STSM is to carry out a collaborative research project on topics relevant to the network

  • Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and...

    October 2022 Pharmacological targeting of cGAS/STING-YAP axis suppresses pathological angiogenesis and Pharmacological targeting of cGAS/STING-YAP signaling by both a small-molecule STING agonist, SR-717, Further, pharmacological targeting of cGAS/STING-YAP axis exhibits the potential to alleviate liver and

  • Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders with ...

    April 2022 Applying Allosteric Modulator Pharmacology to Treat Dyskinesia and Other Movement Disorders Addex Therapeutics "Tim Dyer is the Co-Founder and CEO of Addex Therapeutics, which is focusing on the pharmacology

  • 📰 GPCR Weekly Buzz: Exciting Schedule Shifts for Principles of Pharmacology I & II | August 12-18, 2024

    We’ve made some updates to the Principles of Pharmacology I & II courses, and we can’t wait for you Here’s the refreshed schedule: Principles of Pharmacology I October 3, 10, 17, 24 Principles of Pharmacology Don’t miss out on insightful resources like '   Applying Pharmacology to Drug Discovery ' and ' Advanced Data Analysis for GPCR Pharmacology .' Don’t miss your chance to dive into the Principles of Pharmacology I & II BUNDLE .

  • Combined docking and machine learning identify key molecular determinants of ligand pharmacological

    detailed structure‐activity relationship that identifies small changes to the ligands that invert their pharmacological

  • 📢 GPCR Update: August 19-25, 2024 | Thrilling Announcement: New Pharmacology Course Dates & Exclusive Discounts Inside!

    GPCR Enthusiasts , Get ready for an exciting learning experience with our newly updated Principles of Pharmacology New Course Dates: Principles of Pharmacology I :  October 3, 10, 17, 24 (four sessions) Principles of Pharmacology II :  October 31, November 7, 14, 21, December 5 (five sessions) Courses Highlights Act Fast: Don’t miss this incredible opportunity to immerse yourself in the  Principles of Pharmacology and ' Advanced Data Analysis for GPCR Pharmacology' ."

  • GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between ...

    GPCRs Are Optimal Regulators of Complex Biological Systems and Orchestrate the Interface between Health and Disease GPCRs arguably represent the most effective current therapeutic targets for a plethora of diseases. GPCRs also possess a pivotal role in the regulation of the physiological balance between healthy and pathological conditions; thus, their importance in systems biology cannot be underestimated. The molecular diversity of GPCR signaling systems is likely to be closely associated with disease-associated changes in organismal tissue complexity and compartmentalization, thus enabling a nuanced GPCR-based capacity to interdict multiple disease pathomechanisms at a systemic level. GPCRs have been long considered as controllers of communication between tissues and cells. This communication involves the ligand-mediated control of cell surface receptors that then direct their stimuli to impact cell physiology. Given the tremendous success of GPCRs as therapeutic targets, considerable focus has been placed on the ability of these therapeutics to modulate diseases by acting at cell surface receptors. In the past decade, however, attention has focused upon how stable multiprotein GPCR superstructures, termed receptorsomes, both at the cell surface membrane and in the intracellular domain dictate and condition long-term GPCR activities associated with the regulation of protein expression patterns, cellular stress responses and DNA integrity management. The ability of these receptorsomes (often in the absence of typical cell surface ligands) to control complex cellular activities implicates them as key controllers of the functional balance between health and disease. A greater understanding of this function of GPCRs is likely to significantly augment our ability to further employ these proteins in a multitude of diseases. Read full article

  • Perkins’ Head of Molecular Endocrinology and Pharmacology, Professor Kevin Pfleger, was appointed...

    December 2021 Perkins’ Head of Molecular Endocrinology and Pharmacology, Professor Kevin Pfleger, was appointed President of the Australasian Society of Clinical and Experimental Pharmacologists and Toxicologists Coincidentally, on the same day, Prof Pfleger was announced as a Fellow of the British Pharmacological ASCEPT is the peak professional society devoted to advancing excellence in Clinical and Experimental Pharmacology Established in 1966, ASCEPT is affiliated with the International Union of Basic and Clinical Pharmacology

  • Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, behavior...

    August 2022 Dopamine D 1 receptor-mediated β-arrestin signaling: Insight from pharmacology, biology, We now summarize important pharmacological, molecular, and cellular studies relevant to D1-mediated β-arrestin-related

  • A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology in...

    August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology monitor the activation state of G protein-coupled receptors are a useful addition to the molecular pharmacology

  • 📰 GPCR Weekly News

    Exploring pharmacological inhibition of Gq/11 as an analgesic strategy. Network pharmacological investigation into the mechanism of Kaixinsan powder for the treatment of depression With Long Short-Term Memory Neural Network. Current Technologies To Understand G-Protein-Coupled Receptor Molecular Pharmacology. June 4-8,2023. 2023 Molecular Pharmacology (GRS) Seminar GRC. June 10 - 11.

  • 📰 GPCR Weekly News, March 25 to March 31, 2024

    Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between Terry Kenakin’s Applying Pharmacology to Drug Discovery course. Continue to increase your knowledge of Pharmacology by joining this practical approach class today. , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Director of Laboratory

  • Exciting GPCR Events for Next Year! + GPCR Weekly Rocket Launch ⦿ Oct 28 - Nov 3, 2024

    Tomas , Kyle Sloop , et al. for their outstanding study on Class B1 GPCRs: insights into multireceptor pharmacology November 26 - 28, 2024 | GPCRs-Targeted Drug Discovery Summit Europe NEW December 10 - 12, 2024 | Pharmacology | BIO International Convention 2025 July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Research Associate - Professor Graeme Milligan Postdoc in Molecular Pharmacology - The Hauser Group pharmacology and molecular docking The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor

  • 📰 GPCR Weekly News, September 25 to October 1, 2023

    nasopharyngeal carcinoma Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks and Rho GTPase components to potentiate bacterial survival in Dictyostelium Reviews, GPCRs, and more Network pharmacology -based study on the mechanism of traditional Chinese medicine in the treatment of glioblastoma Cytokines GPCR Jobs NEW In vivo Antibody Discovery Research Scientist NEW In Vitro Biologist/Molecular Pharmacologist

  • Rescue of Cell Surface Expression and Signaling of Mutant Follicle-Stimulating Hormone Receptors

    Pharmacological chaperones are cell-permeant small molecules that engage nascent mutant GPCRs in the Therefore, CAN1404 acts as a pharmacological chaperone and can rescue cell surface expression and function effects of genetic mutations on GPCR function and provide a proof of therapeutic principle for FSHR pharmacological

  • 📰 GPCR Weekly News, May 20 to 26, 2024

    GPCR University workshop on Advanced Data Analysis for GPCR Pharmacology, led by the esteemed Dr. GPCR Matchmaking Read Mark's job spotlight article for a Principal Scientist in In Vitro Pharmacology Mark recently discussed this exciting opportunity with Beth Fleck, Director of In Vitro Pharmacology 2026 GPCR Jobs HIGHLIGHT Principal Scientist, In vitro pharmacology NEW Senior Scientist - Receptor Pharmacology NEW PostDoctoral Scientist Senior Research Associate/Associate Scientist, Protein Science

  • 📰 GPCR Weekly News, July 1 to 7, 2024

    Gunnar Schulte for his study on the International Union of Basic and Clinical Pharmacology. Jianming Han, Tao Che for their analysis of GPCR-G protein selectivity revealed by structural pharmacology Here’s a sneak peek at what you can expect: Principles of Pharmacology in Drug Discovery I - Techniques Principles of Pharmacology in Drug Discovery II - Advanced Methods for the Optimization of Candidate degradation technologies to G protein-coupled receptors Unravelling G protein-coupled receptor signalling networks

  • 📰 GPCR Weekly News, April 1 to 7, 2024

    Samuel Hoare on Advanced data analysis for GPCR pharmacology, which will be held on Thursdays between This is an excellent opportunity to network and increase your visibility on our platform. , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology Research Unit Postdoctoral Scholar – Synaptic physiology, optical imaging, substance use disorder, pharmacology Research Fellow Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior Join Dr.

  • 📰 GPCR Weekly News, February 12 to 18, 2024

    GPCR University course, 'Applying Pharmacology to Drug Discovery,' led by Dr. and more Nanobody-Mediated Dualsteric Engagement of the Angiotensin Receptor Broadens Biased Ligand Pharmacology Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist Spring in Barcelona GPCR Events, Meetings, and Webinars February 20, 2024 | Career Opportunities in Pharmacology 2026 GPCR Jobs NEW Research Fellow NEW  Postdoctoral Fellow – Molecular Pharmacology of Feeding Behavior

  • 📰 GPCR Weekly News, June 24 to 30, 2024

    Matthew Eddy, et al. for their investigation on Interaction Networks within Disease-Associated GαS Variants , 2024 | 11th Adhesion GPCR Workshop July 12 - 17, 2026 | 20th World Congress of Basic and Clinical Pharmacology 2026 GPCR Jobs NEW Scientist; Biochemistry, Cellular and Mechanistic Pharmacology; Lead Discovery and Director GPCR Drug Discovery Biologist HIGHLIGHT Principal Scientist, In vitro pharmacology Post-Doctoral Scientist- Molecular Pharmacology (FDE) Research Assistant Senior Scientist - Receptor Pharmacology

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