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27 items found for "Neuroendocrine immunomodulatory axis"
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
News < GPCRs in Oncology and Immunology Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine and the hypothalamic‒pituitary‒adrenal (HPA) axis. and the HPA axis was explored by histology and multitissue transcriptomics, and the neuroendocrine-immune underlying SCI-IDS, this study assessed the differential regulation of the gene network associated with neuroendocrine , Neuroendocrine immunomodulatory axis , Neuroinflammation , SCI-induced immunodeficiency syndrome ,
- Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors
Proteogenomic landscape and clinical characterization of GH-producing pituitary adenomas/somatotroph pituitary neuroendocrine clinical characteristics of growth hormone (GH)-producing pituitary adenomas/somatotroph pituitary neuroendocrine
- Ep 35 with Dr. Brian Arey
He obtained both his MS and Ph.D. in Neuroendocrine Physiology at Florida State University before completing
- Ep 34 with Dr. Brian Arey
He obtained both his MS and Ph.D. in Neuroendocrine Physiology at Florida State University before completing
- Aberrant hormone receptors regulate a wide spectrum of endocrine tumors
GIPR, and somatostatin receptors in medullary thyroid carcinoma; and SSTRs, GLP1R, and GIPR in other neuroendocrine
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
Somatostatin receptors are clinically validated GPCR biomarkers for diagnosis and treatment of various neuroendocrine
- Ascitic Shear Stress Activates GPCRs and Downregulates Mucin 15 to Promote OvarianCancer Malignancy
These findings along with a shear-induced immunomodulatory secretome position elevated shear stress as
- Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients
HCMV-created immunomodulatory mechanisms could be associated with the indirect effects.
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis US28 expression increased the abundance of the key components of the S1P signaling axis, including an US28 also activated the S1P signaling axis in HCMV-infected cells.
- Evolutionary diversity of CXCL16-CXCR6: Convergent substitutions and recurrent gene loss in sauropsids
substitutions and recurrent gene loss in sauropsids Published date October 14, 2024 Abstract "The CXCL16-CXCR6 axis This axis is linked to diseases like HIV/SIV, cancer, and COVID-19. Together, these highlight that the CXCL16-CXCR6 axis is pivotal in host immunity. Previous studies of the CXCL16-CXCR6 axis found genetic variation among species but were limited to primates
- A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization during bacterial infection
< GPCR News < GPCRs in Oncology and Immunology A GPCR-neuropeptide axis dampens hyperactive neutrophils Specifically, the Mrgpra1-NPFF axis counter-regulated interferon (IFN) γ-mediated neutrophil polarization
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction CD8-restricted Gαs-DREADD to activate CD8-restricted Gαs signaling and show that a Gαs-PKA signaling axis
- The pyruvate-GPR31 axis promotes transepithelial dendrite formation in human intestinal dendritic cells
< GPCR News < GPCRs in Oncology and Immunology The pyruvate-GPR31 axis promotes transepithelial dendrite
- From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal transduction
GPCRs in Oncology and Immunology From outside to inside and back again: the lysophosphatidic acid-CCN axis
- A disturbed metabolite-GPCR axis is associated with microbial dysbiosis in IBD patients: Potential role of GPR109A in macrophages
< GPCR News < GPCRs in Oncology and Immunology A disturbed metabolite-GPCR axis is associated with microbial The aim of this study was to characterize the axis microbiota-metabolite-GPCR in intestinal surgical
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
The CCR6/CCL20 axis plays a fundamental role in immune homeostasis and activation. against CCR6 that could be a promising alternative to small molecules in the treatment of CCR6/CCL20 axis-related
- GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis
GPR37 promotes colorectal cancer against ferroptosis by reprogramming lipid metabolism via p38-SCD1 axis
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
One aspect of PDAC is elevated ATP levels, pointing to the purinergic axis as a potential attractive Mediated in part by highly druggable extracellular proteins, this axis plays essential roles in fibrosis
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
cisplatin-refractory ovarian cancer xenografts, demonstrating the therapeutic potential of targeting LPAR-UCA1-let-7 axis Thus, our results identify LPAR-UCA1-let-7 axis as a novel avenue for targeted treatment strategies."
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
Immunology GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis
- Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα/FARP1/Cdc42 axis
- Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling
GPR37 to increase expression of the efferocytosis receptor Tim4 via an ERK-AP1-dependent signaling axis
- GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer
The GPR176/GNAS complex inhibits mitophagy via the cAMP/PKA/BNIP3L axis, thereby promoting the tumorigenesis
- Enterococcus-derived tyramine hijacks α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis
Importantly, blocking the axis with an ADRA2A antagonist, yohimbine, disrupts tyramine-mediated suppression
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
apoptosis, inflammation, and osteogenic differentiation inhibition in hDPSCs via the miR-708-5p/GIT2 axis
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
predominant GPCR-mediated microbial metabolite-human cell interactions regulating gut-immune-brain axis
- Student Flash Presentations | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
This regimen has long lasting side-effects, including neuroendocrine and cognitive problems, and ~ 30%