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In this study, we evaluated the role of the astrocytic Gi pathway in neuroinflammation using a Gi -coupled Gi -DREADD was expressed in hippocampal astrocytes of a lipopolysaccharide (LPS)-induced neuroinflammation We found that astrocyte Gi -DREADD stimulation using clozapine N-oxide (CNO) inhibits neuroinflammation Taken together, our results indicate that the astrocytic Gi pathway plays an inhibitory role in neuroinflammation , providing an opportunity to identify potential cellular and molecular targets to control neuroinflammation

respond to cannabinoids which has implications for the development of cannabinoid-based treatments for neuroinflammation

Disorders GPCRs in Oncology and Immunology Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation

News < GPCRs in Oncology and Immunology Exacerbating effects of single-dose acute ethanol exposure on neuroinflammation and amelioration by GPR110 (ADGRF1) activation Published date August 14, 2023 Abstract "Background: Neuroinflammation pharmacological activation of GPR110 in both central and peripheral immune cells cooperatively ameliorates neuroinflammation

Progressive neuroinflammation spreads after injury, and neurotransmission through Gi-mediated G protein-coupled Zhou , Jin-Wu Wang Tags Hypothalamo-pituitary-adrenal axis , Neuroendocrine immunomodulatory axis , Neuroinflammation

ligand-induced signaling causes object recognition and spatial memory deficits in adulthood and increased neuroinflammatory gene expression for neuronal differentiation, axonogenesis, and synaptogenesis, as well as altered neuroinflammatory