Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells. As research in this area expands, further insights are made into the role of neuropeptides and their , which is likely due to complex interactions among neuropeptides, receptor isoform-specific signaling However, progress in this area has led to an increase in studies that have begun modulating neuropeptide This review focuses on the role of neuropeptides in maintaining the homeostasis of the ocular surface

October 2022 "Numerous physiological processes in insects are tightly regulated by neuropeptides and Although they form an ancient signaling system, there is still a great deal of variety in neuropeptides Neuropeptides and their receptors have been documented in many hemipteran insects, but the differences Here, 33 neuropeptide precursors and 48 putative neuropeptide G protein-coupled receptor (GPCR) genes This research provides more knowledge on neuropeptide systems and sets the groundwork for the creation

Here we report that neuropeptide S (NPS) signaling in the PVT is necessary for stimulus salience encoding

November 2022 "Neuropeptides produce robust effects on behavior across species, and recent research has Neuropeptides exhibit distinct characteristics which includes their post-translational processing, release These complex properties have driven the need for development of specialized tools that can sense neuropeptide Current research has focused on isolating when and how neuropeptide transmission occurs, as well as the conditions in which neuropeptides directly mediate physiological and adaptive behavioral states.

Coordinated transcriptomics and peptidomics of central nervous system identify neuropeptides and their Neuropeptides and their specific receptors (primarily G protein-coupled receptors, GPCRs) regulate multiple Overall, 57 neuropeptide precursor genes were identified and 128 various mature peptides were predicted A total of 41 neuropeptide GPCR genes belonging to three classes were also identified. and their GPCRs in G. molesta; and to develop specific neuropeptide-based agents for this tortricid

reveals the basis of ligand specificity and how binding affects the G-protein interface "Galanin is a neuropeptide of GALR2 bound to galanin and a cognate heterotrimeric G-protein, providing a molecular view of the neuropeptide

GPCR Binders, Drugs, and more Molecular Characterization of Two Wamide Neuropeptide Signaling Systems and Molecular Insights into GPCR Function Structure-Activity Relationship Study of the High-Affinity Neuropeptide

embryonic stem cells via JAK1/STAT3 signaling pathway GPCR Binders, Drugs, and more Global analysis of neuropeptide tegmental area amylin / calcitonin receptor signaling suppresses feeding and weight gain in female rats Neuropeptide

dopaminergic neurons A new GRAB sensor reveals differences in the dynamics and molecular regulation between neuropeptide helix 8 solution structure and orientation using a neurotensin receptor 1 peptide Illuminating the neuropeptide

and freshwater water flea (Daphnia magna) reveals a high level of orthological relationship of amine, neuropeptide

GPCRs in Neuroscience The head mesodermal cell couples FMRFamide neuropeptide signaling with rhythmic

action, promotes adipocyte browning, and protects against diet-induced obesity GPCRs in Neuroscience The neuropeptide

Neuroscience An emerging multi-omic understanding of the genetics of opioid addiction A FMRFamide-like neuropeptide

Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and Release.

The G protein-coupled receptor neuropeptide receptor-15 modulates larval development via the transforming

role of orphan receptor GPR139 in neuropsychiatric behaviours Rhodopsin orphan GPCR20 interacts with neuropeptides

GPCRs in Neuroscience Neuronal diversity of neuropeptide signaling, including galanin, in the mouse locus

Function Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide

inflammation-mutation model Methods & Updates in GPCR Research Current and emerging methods for probing neuropeptide

FFAR4 improves the senescence of tubular epithelial cells by AMPK/SirT3 signaling in acute kidney injury Emerging approaches for decoding neuropeptide transmission. Oncogenic signaling of the free-fatty acid receptors FFA1 and FFA4 in human breast carcinoma cells.

Molecular mechanism of fatty acid activation of FFAR1. Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration

Endogenous l- to d-amino acid residue isomerization modulates selectivity between distinct neuropeptide

and GPCR ligand binding GPCRs in Oncology and Immunology Neutrophils are itching to specialize A GPCR-neuropeptide

pluripotency of mouse embryonic stem cells via JAK1/STAT3 signal pathway A fluorescently-tagged tick kinin neuropeptide

Reviews, GPCRs, and more Understanding Neuropeptide Transmission in the Brain by Optical Uncaging and

and regulation of GPR84 in human neutrophils Large-scale deorphanization of Nematostella vectensis neuropeptide

chemokine signaling, extending to numerous other GPCR-regulated systems such as free fatty acid receptors (FFARs

systems A high-throughput structural dynamics approach for identification of potential agonists of FFAR4