August 2022 A NanoBRET-Based H 3 R Conformational Biosensor to Study Real-Time H 3 Receptor Pharmacology

Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney.

Nicole (Nicki) Perry-Hauser is now available What a fun chat! 📹Would you like to see the video?

Nicholas Holliday and how he has combined his university role with his leadership of Excellerate Bioscience

., Choi, H. J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. H., Pautsch, A., Steyaert, J., Weis, W. I., & Kobilka, B. K. (2011). M., Manglik, A., Hu, J., Hu, K., Eitel, K., Hübner, H., Pardon, E., Valant, C., Sexton, P. O., Ploegh, H. L., & Garcia, K. C. (2015). Structural biology. D., Tworak, A., Watanabe, K., Pardon, E., Steyaert, J., Kandori, H., Katayama, K., Kiser, P.

peroxidase enzyme that catalyzes the oxidation of specific substrates in the presence of hydrogen peroxide (H When AUR is oxidized by APEX2 in the presence of H 2 O 2 , it produces a fluorescent product that can

., Dohlman, H. G., Frielle, T., Bolanowski, M. A., Bennett, C. D., Rands, E., Diehl, R. G., & Schiöth, H. B. (2003). M., Pérez-Hernández, G., Batebi, H., Gao, Y., Eskici, G., Seven, A.

Unlike LGR2 in other insect species, HLGR2 was found to play a crucial role in the control of H. cunea Conclusion: HLGR2 is essential for the growth and development and wing expansion and maturation in H.

than 60 ORs in the testis and only a few ORs in the liver (Flegel C. et al. 2013; Maßberg D. and Hatt H. although there are highly increased in prostate tissue, especially in prostate cancer (Maßberg D. and Hatt H. olfactory-specific chaperones to be correctly targeted to the surface of heterologous cells (Maßberg D. and Hatt H.

References Eishingdrelo, H., & Kongsamut, S. (2013). Wei, H., Ahn, S., Shenoy, S. K., Karnik, S. S., Hunyady, L., Luttrell, L. M., & Lefkowitz, R.

will facilitate further development of therapeutic agents targeting the DOR.Communicated by Ramaswamy H.

study on Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins Nicholas

F et al. 2021, Chen, H. et al. 2022). H., & Lee, J. H. 2020, Casiraghi, M. et al. 2019), double electron-electron resonance (DEER) spectroscopy for high-resolution

expression, restoration to ≥57% of WT levels was achieved for 6 by treatment with 1 µM CAN1404 for 24 h,

Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease

Of 161 molecules tested, 42 substituted more than 50% of [³H]-LSD at 10 μM, achieving a 26% hit rate.

October 21st to 27th, 2024 Industry News UNC School of Medicine to Receive $3-Million Award from ARPA-H’

Nature chemical biology, 5(10), 734–742. https://doi.org/10.1038/nchembio.206 Wei, H., Ahn, S., Shenoy Z., Wilderman, A., Katakia, T., McCann, T., Yokouchi, H., Zhang, L., Corriden, R., Liu, D., Feigin, M

Zhang, H., et al., Autocrine selection of a GLP-1R G-protein biased agonist with potent antidiabetic

H., Heydenreich, F. M., Kawakami, K., Masureel, M., Maeda, S., Garcia, K.

., Yin, H., Xiong, Y., Zhang, A., Guo, C., Chen, Z., Huang, Z., & He, Y. (2022).

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George H. Edmond H.

article Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery Nicola

of a small protein GPCR ligand using new peptide chemistry technology and rational design Gaertner, H.