Nicola Smith, Molecular Pharmacologist, lab head, and senior lecturer at UNSW Sydney.

regarding the role of C3aR in controlling bacterial infections and analyze these results in the context of both

Nicole (Nicki) Perry-Hauser is now available What a fun chat! 📹Would you like to see the video?

October 2022 Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein PKC and mutation of rat mGlu5a Ser901, a PKC-dependent phosphorylation site in the receptor C-tail, both This indicates that isozymes from both classes are involved, compensate for the absence of the other

structure-based technology has passed a key test, in enabling the discovery of orally available small molecules aimed

article Extracellular signal-regulated kinases – a potential pathway for GPCR-targeted drug discovery Nicola

Nicholas Holliday and how he has combined his university role with his leadership of Excellerate Bioscience

studies have also reported GPR84 involvement in pain, atherosclerosis, and even metabolic disorders (Nicol GPR84 is a promising target to exploit and the investment in better tools to study its function in both

adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling Jiankun Lyu, Brian Shoichet, Bryan Roth Stay tuned for further details, as we plan to open registrations for both courses in July 2024. Dr. Protein-Coupled Adenosine A2A Receptor AlphaFold2 structures guide prospective ligand discovery Industry News Roche

study on Multiplexed mapping of the interactome of GPCRs with receptor activity-modifying proteins Nicholas

Bryan L Roth study on Illuminating the understudied GPCR-ome Save the dates: February 8 - 29: Dr. Registrations open on December 15th and close on February 1st to both Dr.

Stuart Maudsley, Nicole Perry-Hauser, Lauren Slosky, Cesare Orlandi, and Simone Prömel.

Nichola J Smith's investigation: Gene expression of TAS1R taste receptors for cardiometabolic disease

Bryan Roth There are 10 open tickets available. Get yours now!

fantastic paper on Development of Putative Bivalent Dicovalent Ligands for the Adenosine A1 Receptor Bryan Roth faculty members who adeptly simplify the intricacies of GPCR pharmacology for practical application in both We aim to make education accessible to all!

Nicole Perry-Hauser, on her selection as a 2024 Discovery Science Emerging Scholar at Vanderbilt University

Bryan Roth, Sudarshan Rajagopal, and Graeme Milligan. Save the date! Dr.

C GPCRs, are obligate dimers, either as homodimers or heterodimers, with distinct conformations in both Recent studies suggest that class B1 GPCRs can form both homodimers and heterodimers, which may play that GLP-1R homodimerization occurs via transmembrane helix 4 (TM4), which forms the interface for both result, dimerized SecR receptors exhibit higher rates of G protein activation and release, improving both

October 2022 "The activity of dopamine neurons is dependent on both intrinsic properties and afferent applications of sub-saturating concentrations of agonists where the co-application of one agonist resulted in both results suggest that the cooperative interaction between G βγ subunits and GIRK channels determines both Coincident activation of D2 and GABAB receptors leads to facilitation of GIRK channel currents, augmenting both

Bryan Roth and Brian Krumm   for their study on Molecular glues as potential GPCR therapeutics Drs

Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr.

Bryan Roth's work on "Built-in functional selectivity in neurons is mediated by the neuronal protein,

The cytoskeletal protein filamin A (FLNA) directly interacts with both somatostatin receptor type 2 ( A7), and octreotide but not pasireotide promoted hetero-dimerization in both A7 and M2 (+20.0 ± 11.8% On the contrary, in M2 cells, octreotide failed to internalize both receptors whereas pasireotide promoted In conclusion, we demonstrated that in GH3 cells SST2 and SST5 can form both homo- and hetero-dimers

Additionally, we employed optical assays in living cells to thoroughly profile both GPR35 isoforms for basis for this bias, we examined structural models of GPR35 and conducted experiments with mutants of both found that a proposed disulfide bridge between the N-terminus and extracellular loop 3, present in both

Brian Krumm and Bryan Roth studied CryoEM structures of adhesion in GPCR CD97, filling gaps.

However, controversy remains regarding its role in breast cancer since both pro- and anti-metastatic We show that both cell lines express KISS1R mRNA and respond to KP-10 by elevating calcium mobilisation Interestingly, both cell lines displayed different complements of β-arrestin 1 and 2 expression.

single-domain antibody fragments from camelids, have become indispensable tools for interrogating GPCRs both technologies to discover nanobodies with tailored specificities may expand the impact of these tools for both

proteomics revealed that in the interactome of VLGR1, molecules are enriched that are associated with both mitochondria, as well as mitochondria-associated ER membranes (MAMs), a compartment at the contact sites of both