The most recent Nobel prize awarded for work relevant to GPCR-mediated signaling was the 2012 Nobel Prize The Nobel Prize in Physiology or Medicine 1947. https://www.nobelprize.org/prizes/medicine/1947/summary Nobel Prize: Three Named for Medicine, Physiology Award. NobelPrize.org. https://www.nobelprize.org/prizes/uncategorized/the-nobel-prize-in-physiology-or-medicine The Nobel Prize in Chemistry 2012 - NobelPrize.org. https://www.nobelprize.org/prizes/chemistry/2012/

Structural diversity of leukotriene G-protein coupled receptors Industry News Duke University Celebrates Nobel Prize Winner Robert Lefkowitz’s 50 Years of Scientific Discovery Novo Nordisk Foundation Grants Fuel

vision for expanding GPCR landscape The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Chemistry 2024 Septerna Announces Initiation of Phase 1 Clinical Trial with SEP-786, a Novel

In 2017, Gupte et al. introduced GPCR priming, which posits that non-cognate G proteins can enhance the This priming effect occurs through non-functional interactions between non-cognate G proteins and GPCRs The enhanced signalling observed in GPCR priming is attributed to the formation of temporal non-cognate-GPCR significant implications for drug development, as targeting these non-cognate interactions could lead to novel Gupte, T.M., et al., Priming GPCR signaling through the synergistic effect of two G proteins. 

October 2022 Novel Therapies for Cardiometabolic Disease: Recent Findings in Studies with Hormone Peptide-Derived The present review describes novel findings regarding the complex biology of the preproglucagon-derived

Transmembrane domains of GPCR dimers – a novel hot spot for drug discovery G-protein-coupled receptors

August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression patterns differ between species and change during development. Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified and the majority of these isoforms are yet to be characterized. Moreover, the mechanisms underlying regulation of TRPM3 are largely unexplored. In addition, a micro-RNA gene (miR-204) is located within the TRPM3 gene. This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics. However, a clear picture is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target. Therefore, the newest data related to TRPM3 have to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation from bench to bedside. The aim of this review is to highlight recent results and developments with particular focus on findings from studies involving ocular tissues and cells or peripheral neurons of rodents and humans." Read more at the source #DrGPCR #GPCR #IndustryNews

October 2022 Case Report of a Juvenile Patient with Autism Spectrum Disorder with a Novel Combination

October 2022 Identification of A2BAR as a potential target in colorectal cancer using novel fluorescent

September 2022 Dimerization of GPCRs: Novel insight into the role of FLNA and SSAs regulating SST2 and

May 2022 Sosei Heptares and Kallyope Enter Collaboration to Identify and Validate Novel Gastrointestinal involving the gut-brain axis, have entered a strategic research collaboration to identify and validate novel

September 2022 "Background Cancer driver genes are usually ranked by mutation frequency, which does not necessarily reflect their driver strength. We hypothesize that driver strength is higher for genes preferentially mutated in patients with few driver mutations overall, because these few mutations should be strong enough to initiate cancer. Methods We propose formulas for the Driver Strength Index (DSI) and the Normalized Driver Strength Index (NDSI), the latter independent of gene mutation frequency. We validate them using TCGA PanCanAtlas datasets, established driver prediction algorithms and custom computational pipelines integrating SNA, CNA and aneuploidy driver contributions at the patient-level resolution." Read more at the source #DrGPCR #GPCR #IndustryNews

We uncovered a novel neuroprotective mechanism involving interaction between neurotrophic factor-α1 (

November 2021 Twist Bioscience Launches Revelar Biotherapeutics to Develop and Commercialize Novel COVID

OMass Therapeutics , which is based at Oxford Science Park, has been awarded the 2022 Louis-Jeantet Prize

October 2022 Use of CRISPR/Cas9-edited HEK293 cells reveals that both conventional and novel protein generated and characterized human embryonic kidney 293A (HEK293A) cell lines devoid of conventional or novel

clinical-stage pharmaceutical company focused on the discovery, development and commercialization of novel therapeutics for rare endocrine diseases and endocrine-related tumors, announced today the pricing of an underwritten follow-on offering of 5,625,563 shares of its common stock at a price to the public

2021 OMass Therapeutics 's founder, Carol Robinson , has been awarded the prestigious Louis-Jeantet Prize congratulations to our founder, Carol Robinson , who has been awarded the prestigious Louis-Jeantet Prize

April 2022 John Streicher talks about his work on terpenes found in cannabis as these may be a novel These compounds may be a novel way to treat pain without the negative side effects of cannabinoids or

In this study, we report the discovery of a novel lead compound for S1R binding, based on the thiazolidine

The company's co-founder, GPCR pioneer and Nobel laureate Robert Lefkowitz , M.D., has 50 years of experience

adrenoceptors and exerting BRL37344-like effects on mouse metabolism Development, synthesis and evaluation of novel medical research ‘Define your own success’: Duke leaders talk success, failure at symposium honoring Nobel

Development of Photoswitchable Tethered Ligands that Target the µ-Opioid Receptor Design and Synthesis of Novel formation in the social amoeba Dictyostelium discoideum evolved under low relatedness Industry News Nobel

2022 "G protein-coupled receptors (GPCRs) play critical roles in human physiology and are one of the prime available today, will facilitate structure-based discovery and development of allosteric modulators as novel

Gαs slow conformational transition upon GTP binding and a novel Gαs regulator. Industry News X4 Pharmaceuticals Announces $65 Million Private Placement Priced At-the-Market Andrew Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

Pharmacological characterization of novel small molecule agonists and antagonists for the orphan receptor Highlighting the Importance and Challenges in Unlocking “Undruggable” GPCRs Endocrine Society Awards Baxter Prize Progressive Technologies and Approaches Revealing Novel GPCR Biology and Drug Development Potential.

platform from target identification through patient selection Research will be focused on up to 15 novel announced today a groundbreaking research collaboration and license agreement to develop up to 15 novel The companies have been working together since 2016 and in 2019, Sanofi in-licensed Exscientia ’s novel

Recently, many novel discoveries have underlined the regulatory roles of neurotransmitters in the microenvironment Here, we provide an overview of the most novel advances concerning the role of neurotransmitters in the