therapy resistance in high-grade serous ovarian carcinoma cells, whereas silencing UCA1 reverses these oncogenic UCA1 sequesters let-7 miRNAs, effectively neutralizing their tumor-suppressive functions involving key oncogenes Yong Sang Song , Danny N Dhanasekaran Tags GPCR , High Grade Serous Ovarian Carcinoma , Let-7 miRNAs , Oncogenic Pathways , Ovarian Cancer , Therapy Resistance , UCA1 , lncRNA Source Contribute to the GPCR News Coming

by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid that stimulates oncogenic pathways in glioblastoma.

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation Published date July 16, 2024 Abstract CysLT2R was impaired at activating the FAK/YAP/TAZ pathway relative to Gαq/11. our bioinformatic analysis uncovers a role for co-occurring mutations involving the plexin/semaphorin pathway , which has been shown capable of activating this pathway.

EBV-induced lymphomagenesis Published date November 15, 2023 Abstract "Epstein-Barr virus (EBV) is the oncogenic Our multi-omics analysis of NKTCL revealed that EBV gene pattern correlated with immune-related oncogenic

Pharmacological inhibition of the lipid synthesis pathway by statins is a therapeutic approach to control Our results may also provide molecular reasoning for repurposing statins as Ras oncogene inhibitors and Waruna Thotamune , John L Payton , Ajith Karunarathne Tags HMG-CoA reductase , cholesterol , mevalonate pathway

J Silvio Gutkind, a class on oncogenes and his interests for GPCRs helped shape his scientific interests

papillomavirus, which are commensal inhabiting the healthy human epithelium (virome) while presenting an oncogenic

It attenuates PAR2 oncogenic activity.

Recently, Tom’s lab discovered, along with Yu Chen and Ping Chi , that a mutant of CYSLTR2 is a driver oncogene

His clinical expertise is in monogenic autoinflammatory disorders and the autoimmune adverse effect resulting Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune observed in ovarian cancer and the identification of emergent vulnerabilities associated with adaptation pathways

studying the role of G-protein coupled receptors (GPCRs) and their regulators in the Wnt signaling pathway in vivo work, and Mike explained that he wanted to use better models to understand cancer signaling pathways to explore the GPCR side of the lab, which led to the discovery of potential tumor suppressors and oncogenes

to adaptively initiate an apoptosis, inflammasome, Nrf2-ARE anti-oxidant, or heat-shock activation pathway requisite co-initiator (acting together with as few as two somatic mutations) of the most efficient pathway impede inflammation resolution (e.g., by doing so for GPCR-mediated signal transduction by one or more endogenous

Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling Pathways Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy

Simultaneous activation of CXCR4 and HRH1 synergistically increases calcium flux in MDA-MB-231 cells that endogenously by the Gαi inhibitor pertussis toxin and the Gαq inhibitor YM254890, suggesting that the Gαi and Gαq pathways

< GPCR News < GPCRs in Oncology and Immunology Context-dependent ciliary regulation of hedgehog pathway In the hedgehog pathway, bifunctional GLI transcription factors generate both GLI-activators (GLI-A) However, how these counterregulatory effectors coordinate cilia-regulated morphogenetic pathways is unclear Here we determined GLI-A/GLI-R requirements in phenotypes arising from lack of hedgehog pathway repression We studied hedgehog pathway repression by the GPCR GPR161, and the ankyrin repeat protein ANKMY2 that

< GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the mining of the molecular events plausibly associated with GPR56 activity, we have constructed a signaling pathway others associated with Wnt, integrin, calcium signaling, growth factors, and inflammation signaling pathways We also considered intracellular and extracellular factors that may influence the activity of the pathway Raksha A Ganesh , Krishnan Venkataraman , Ravi Sirdeshmukh Tags GPR56 /ADGRG1 , Mesenchymal transition , Pathway

Domain Autoproteolysis Bill Huang Tethered Agonist Dependent ADGRL3 Signaling Activity In The G12/13 Pathway WNT pathway activation in WNT-MB is driven by mutations of the CTNNB1 gene, activating ß-catenin-dependent signaling; however, no interactions between BAI3 and the WNT signaling pathway have been described so We will present the effects of BAI3 re-expression on WNT-MB cells oncogenic properties and signaling. " Bill Huang on the web LinkedIn Tethered Agonist Dependent ADGRL3 Signaling Activity In The G12/13 Pathway

in Oncology and Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway revealed that 27 phosphopeptides corresponding to six proteins were involved in the Hippo signaling pathway Verification experiments demonstrated that downregulation of the Hippo signaling pathway caused by BRS3 demonstrate that BRS3 activation contributes to cell migration through downregulation of the Hippo signaling pathway

cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway Furthermore, Transcriptome sequencing was performed to show enrichment genes and pathways. Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. overexpression of RGS20 affect the proliferation and autophagy of NSCLC through regulating the Hippo pathway Transcriptomic sequencing suggested the involvement of the Hippo signaling pathway in the action of RGS20

and Immunology Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting Moreover, the GprC that classified as sugar sensor, and intracellular adenylate cyclase (AcyA)-cAMP-PKA pathway These studies highlight a crucial G protein signaling pathway for cell communication that is mediated

< GPCR News < GPCRs in Oncology and Immunology GPR68-ATF4 signaling is a novel prosurvival pathway in hallmark of GBM is a highly acidic tumor microenvironment, which is thought to activate pro-tumorigenic pathways specific small molecule inhibitor of GPR68 named Ogremorphin (OGM) to induce the iron mediated cell death pathway To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq.

< GPCR News < GPCRs in Oncology and Immunology Wnt pathway inhibition with the porcupine inhibitor LGK974 Gs-GPCR signaling, suggesting that targeting the Gs-GPCR or components of the downstream signaling pathway The Wnt signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts insights into the role of Wnt and Gs-signaling in fibrosis and bone formation in a mouse model of Gs-GPCR pathway Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao Tags Wnt pathway

muscarinic receptors induces IFN-γ but suppresses IL-2 production by inhibiting activation of pAKT pathways phosphorylation of downstream signaling molecules and the phosphatidylinositol, Ras, MAPK, and PI3 kinase pathways G-protein-coupled human muscarinic receptor could bypass tyrosine kinases to activate the phosphatidylinositol pathway Interestingly, stimulation of hM3Dq resulted in reduced pAKT and its downstream pathway. reduced IL-2 production in TCR-stimulated hM3Dq/β1 CD4 T cells, suggesting that activating the pAKT pathway

Synaptamide, an endogenous ligand for GPR110, binds to the N-terminal G-protein autoproteolysis-inducing parallel differential expression of kidney proteins in GPR110 KO and WT mice by label-free LC-MS/MS and pathway Importantly, the signaling pathways underlying sexual reproduction in these different contexts have not

Part II: Cell Cycle, DNA Damage Response, and Apoptosis Pathways Published date October 31, 2023 Abstract related to cell growth and migration, specifically the RTK-, integrin-, GPCR-, and calcium-signaling pathways Here we describe drug effects on pathways associated with cell cycle, DNA damage response (DDR), and Drug combination effects on protein changes in the cell cycle- and apoptosis pathways contribute to the

: RAMP-interacting GPCR Pathways Date & Time Thursday, November 2nd / 4:30 PM Keynote Talk Abstract Coming

Methods: To investigate the activated biological pathways in HCMV infection, total RNA was extracted Afterward, Gene Ontology (GO) and pathway enrichment analyses were conducted to determine the enriched pathways and biological processes by DEGs. KEGG pathway analysis revealed the enrichment of DEGs in IL18 signaling, AGE-RAGE signaling pathway in The expression levels of six genes involved in enriched pathways including F3, PTX3, ADRA2B, GNG11, GP9

., either they are involved in negative regulation of EGFR ligands via the ERAD pathway or positively regulate EGFR ligands via the EGFR signalling pathway. However, pathways leading to TACE-dependent EGFR signalling pathways were more observant, specifically MAPK signalling pathways, GPCR signalling pathways, and toll-like receptor pathways. and cytoplasmic ribosomal protein pathways were significantly enriched.