CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation.

September 2022 Interacting binding insights and conformational consequences of the differential activity ligand, showing that the computational techniques utilized to characterize the GPR55 complexes correctly differentiate explored, showing that the computational techniques utilized to characterize the CB1 complexes correctly differentiate interacting loci in the binding sites of the GPR55 and the CB1 receptors that seem to be responsible for the differential

August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment " Background: Inflammatory microenvironment promotes odontoblastic differentiation In this study, we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the Methods: Microarray analysis was performed to explore the differential mRNA profiles in inflammatory TAS2R10 was overexpressed or silenced to observe the effect on odontoblastic differentiation of hDPSCs

The participation of circular RNAs (circRNAs) in DPSC differentiation has been identified. The osteogenic differentiation of hDPSCs was investigated by performing alkaline phosphatase (ALP) staining differentiation in hDPSCs. Conclusions: CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation Tags CircFKBP5 , Inflammation , Osteogenic differentiation , Pulpitis , hDPSCs .

based on RNA-seq Published date August 8, 2023 Abstract "Background: About one-third of patients with estrogen Differentially expressed (DE) genes between experimental groups were characterized based on RNA-seq and Stefan Aebi , Rolf Jaggi Tags Breast cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen

< GPCR News < GPCRs in Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia Published date November 1, 2022 Abstract Blocked cellular differentiation Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid differentiation Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML