Search Results
43 items found for "Osteogenic differentiation"
- CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation
The participation of circular RNAs (circRNAs) in DPSC differentiation has been identified. The osteogenic differentiation of hDPSCs was investigated by performing alkaline phosphatase (ALP) staining differentiation in hDPSCs. Conclusions: CircFKBP5 could protect against LPS-induced apoptosis, inflammation, and osteogenic differentiation Tags CircFKBP5 , Inflammation , Osteogenic differentiation , Pulpitis , hDPSCs .
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
based on RNA-seq Published date August 8, 2023 Abstract "Background: About one-third of patients with estrogen Differentially expressed (DE) genes between experimental groups were characterized based on RNA-seq and Stefan Aebi , Rolf Jaggi Tags Breast cancer cell pools , progesterone response , RNA-seq , CRISPR/Cas9 , estrogen
- Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia
< GPCR News < GPCRs in Oncology and Immunology Activation of orphan receptor GPR132 induces cell differentiation in acute myeloid leukemia Published date November 1, 2022 Abstract Blocked cellular differentiation Here, we showed that genetic activation of the orphan GPCR GPR132 significantly induced cell differentiation of AML both in vitro and in vivo, indicating that GPR132 is a potential trigger of myeloid differentiation Notably, GPR132 activation by 8GL promoted differentiation and reduced colony formation in human AML
- Transcriptomic analysis of human cytomegalovirus to survey the indirect effects on renal transplant recipients
The resulted raw data were analyzed by conventional RNA-Seq software to determine the Differentially pathway in diabetic complications, signaling by GPCR, Platelet activation, signaling and aggregation, Estrogen
- Chemokine N-terminal-derived peptides differentially regulate signaling by the receptors CCR1 and CCR5
< GPCR News < GPCRs in Oncology and Immunology Chemokine N-terminal-derived peptides differentially regulate
- GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway
23 (IL-23) to interlink the innate and adaptive immunity as well as induce T helper 17 (Th17) cell differentiation psoriasis-like skin disease and restricted HaCaT cells abnormal proliferation as well as Th17 cells differentiation affect immune cell enrichment and function in skin and alter keratinocytes proliferation as well as differentiation
- G protein-coupled estrogen receptor (GPER)/GPR30 forms a complex with the β1-adrenergic receptor, a membrane-associated guanylate kinase (MAGUK) scaffold protein, and protein kinase A anchoring protein (AKAP) 5 in MCF7 breast cancer cells
< GPCR News < GPCRs in Oncology and Immunology G protein-coupled estrogen receptor (GPER)/GPR30 forms date January 10, 2024 Abstract "G protein-coupled receptor 30 (GPR30), also named G protein-coupled estrogen
- CaaX-motif-adjacent residues influence G protein gamma (Gγ) prenylation under suboptimal conditions
of G protein γ (Gγ) in a subtype-dependent manner, we investigated the molecular reasoning for this differential expression of different Gγ subtypes, our findings indicate a plausible mechanism allowing for statins to differentially
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Second, the differential regulation of the gene network between the sympathetic-adrenal medullary axis The transcriptome analysis results showed that the downregulated differentially expressed genes (DEGs Conclusions: To explore the possible mechanism underlying SCI-IDS, this study assessed the differential
- Session VIII * | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
This activation promotes neurogenic differentiation of neural stem cells, neurite growth, and synaptogenesis To provide the molecular basis for the renal phenotype, we analyzed in parallel differential expression Garcia De Las Bayonas Abstract "All animals develop through the recognition, adhesion, and fusion of a differentiated
- Ep 111 with Chloe Hicks
three endogenous biased ligands, elucidating the role of site-specific receptor phosphorylation in the differential
- Session VIII | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Physiological and pathological roles of AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated regulation of cardiac health and disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
least absolute shrinkage and selection operator (LASSO) were performed with the aim of identifying differentially Differential expression and functional enrichment analyses were performed; protein-protein interaction
- Ep 148 with Dr Arthur Christopoulos
from Monash University discussed Arthur's career journey, the importance of hard work, failure, and differentiation Additionally, they discussed the importance of hiring based on differentiation, impact, and interest, They discussed the value of hard work, failure, and the significance of differentiation in their personal Hiring Process, Collaboration, and Education-Focused Initiatives Arthur emphasized the importance of differentiation
- Ep 149 with Dr Arthur Christopoulos
from Monash University discussed Arthur's career journey, the importance of hard work, failure, and differentiation Additionally, they discussed the importance of hiring based on differentiation, impact, and interest, They discussed the value of hard work, failure, and the significance of differentiation in their personal Hiring Process, Collaboration, and Education-Focused Initiatives Arthur emphasized the importance of differentiation
- Ep 64 with Dylan Eiger
research focuses on the mechanisms underlying biased signaling at GPCRs, specifically, the role of differential
- GprC of the nematode-trapping fungus Arthrobotrys flagrans activates mitochondria and reprograms fungal cells for nematode hunting
cells for nematode hunting Published date June 14, 2024 Abstract "Initiation of development requires differential
- Deciphering the genetic landscape of lumpy skin disease: Unraveling variable virulence through comprehensive genome sequence analysis in India
Notably, the Ankyrin repeats gene-based analysis could differentiate animals with varying clinical scores
- Autocrine proteinase-activated receptor signaling in PC3 prostate cancer cells
We found several genes that are known PCa prognostic factors or biomarker to be differentially expressed
- Pharmacological inhibition of neuropeptide Y receptors Y1 and Y5 reduces hypoxic breast cancer migration, proliferation, and signaling
The estrogen receptor positive MCF7 cells were significantly less invasive in 3D spheres when NPY5R was
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
and SST3 are associated with apoptosis and cell cycle arrest, making these receptor subtypes better differentiated
- The landscape of cancer-rewired GPCR signaling axes
Multiple GPCRs are differentially regulated together with their upstream partners across cancer subtypes
- GPR56 signaling pathway network and its dynamics in the mesenchymal transition of glioblastoma
Thus, based on transcriptomic, proteomic, and phosphoproteomic differential expression data of GPR56
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
Differential scanning fluorimetry showed AJ-3 to bind RGS2 but not Gαq.
- Trainee Symposium I
GPCR Title: Synapse-Associated Protein 102 and Post-Synaptic Density 95 Differentially Shape Dopamine
- GPR176 promotes fibroblast-to-myofibroblast transition in organ fibrosis progression
Gpr176 acts in a profibrotic manner, and inhibiting its activity could potentially prevent myofibroblast differentiation
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
comprehensive transcriptomic analysis of IM-sensitive and IM-resistant CML groups, we identified the differentially
- Stretch regulates alveologenesis and homeostasis via mesenchymal Gαq/11-mediated TGFβ2 activation
constitutive Gαq/11 gene deletion exhibited abnormal alveolar development, with suppressed myofibroblast differentiation