CCL25/CCR9 interaction promotes the malignant behavior of salivary adenoid cystic carcinoma via the PI3K /AKT signaling pathway "Background CC chemokine receptor 9 (CCR9), an organ-specific chemokine receptor Vercirnon was used as an inhibitor of CCR9, and LY294002 was used as an inhibitor of the PI3K/AKT pathway

Attributable to Elevated Neuron Dendrite Density, Upregulated PSD95 Expression, and Abnormal Activation of the PI3K /AKT/GSK-3β and MEK/ERK Pathways "Adhesion G protein-coupled receptor A1 (ADGRA1) belongs to the G protein-coupled Finally, we found that PI3K/AKT/GSK-3β and MEK/ERK in amygdalae of Adgra1-deficient male mice were aberrantly an important suppressive role of ADGRA1 in anxiety control and synaptic function by regulating the PI3K /AKT/GSK-3β and MEK/ERK pathways in amygdalae of male mice, implicating a potential, therapeutic application

cells and decreases their response to paclitaxel by forming a vicious cycle with IGF1/IGF1R signaling pathway competitively binding to IGF1R with ubiquitin E3 ligase MDM2, thereby activating its downstream signaling pathways such as NF-κB, PI3K/AKT, and MAPK/ERK pathways given their critical roles in breast tumorigenesis and IGF1, in turn, stimulated GASP1 expression by activating the PI3K/AKT pathway, forming a vicious cycle

News < GPCRs in Oncology and Immunology Delivery of US28 by incoming HCMV particles rapidly attenuates Akt and Thr308, in contrast with the phosphorylation of Akt only at Ser473 after WT viral infection. of a constitutively phosphorylated Akt variant triggered lytic replication of wild-type HCMV. ) signaling induced during the entry of WT virus, which led to the site-specific phosphorylation of Akt Thus, particle-delivered US28 fine-tunes Akt activity by limiting HCMV-induced EGFR activation during

expressed on LUAD cells promotes the secretion of chemokines and polarizing factors through activating PI3K /AKT/NF-κB pathway, thereby promoting the migration and invasion of TAMs.

induces the migration of human hepatocellular carcinoma (HCC) HuH7 cells through the activation of AKT family of tyrosine kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) signaling pathway TGF-α-stimulated phosphorylation of JNK without affecting the phosphorylation of epidermal growth factor receptor, AKT subunits act as positive regulators in TGF-α-induced migration of HCC cells via the JNK signalling pathway