October 2022 "The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling pathway PKA facilitates the actions of hormones, neurotransmitters and other signaling molecules that bind G-protein Through its control of synaptic events, exocytosis, transcriptional regulation, and more, PKA signaling Neural PKA signaling is regulated by afferent and peripheral efferent signals that link specific neural While limited, human studies infer differential regulation of the PKA system in obese compared to lean

Learn about communication between GPCRs and PKA, Class F GPCR Smoothened & the Hedgehog signaling pathway

regulation of mTORC1 by upstream stimuli, with a specific focus on G-protein coupled receptor (GPCR) signaling Therefore, understanding the molecular underpinnings of these pathways will undoubtedly be promising

GPCR News < GPCRs in Oncology and Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration Published date June 25, 2023 Abstract "Bombesin receptor subtype signaling pathway, which was significantly regulated by BRS3 activation. Verification experiments demonstrated that downregulation of the Hippo signaling pathway caused by BRS3 signaling pathway."

< GPCR News < GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway Published date January 2, 2023 Abstract Overexpressed VIPR2 caused increases in the levels of cAMP and phosphorylated extracellular signal-regulated kinase (ERK), which involves a VIPR2 signaling pathway through Gs protein. signaling pathway, and the excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma

News < GPCRs in Oncology and Immunology Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling KS-133 in the presence of VIP decreased the phosphorylation of extracellular signal-regulated kinase Our findings suggest that VIPR2 signaling regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K /AKT/GSK3β pathways, and mediates the G1/S transition to control cell proliferation."