signaling pathway Published date March 2, 2024 Abstract " Background: Novel therapeutic targets are Western blotting demonstrated different expressions of autophagy and the Hippo-PKA signal pathway. pathway. Transcriptomic sequencing suggested the involvement of the Hippo signaling pathway in the action of RGS20 signaling pathway , Proliferation , RGS20 Source Contribute to the GPCR News Coming soon Become a Contributor

GPCR News < GPCRs in Oncology and Immunology Dynamic Phosphoproteomics of BRS3 Activation Reveals the Hippo Signaling Pathway for Cell Migration Published date June 25, 2023 Abstract "Bombesin receptor subtype signaling pathway, which was significantly regulated by BRS3 activation. Verification experiments demonstrated that downregulation of the Hippo signaling pathway caused by BRS3 signaling pathway."

< GPCR News < GPCRs in Oncology and Immunology The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction transgenic mice expressing a chemogenetic CD8-restricted Gαs-DREADD to activate CD8-restricted Gαs signaling and show that a Gαs-PKA signaling axis promotes CD8+ T cell dysfunction and immunotherapy failure. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway Published date January 2, 2023 Abstract Overexpressed VIPR2 caused increases in the levels of cAMP and phosphorylated extracellular signal-regulated kinase (ERK), which involves a VIPR2 signaling pathway through Gs protein. signaling pathway, and the excessive expression of VIPR2 may lead to an exacerbation of breast carcinoma

News < GPCRs in Oncology and Immunology Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling G protein-coupled receptor that binds to Gαs, Gαi, and Gαq proteins to regulate various downstream signaling KS-133 in the presence of VIP decreased the phosphorylation of extracellular signal-regulated kinase Our findings suggest that VIPR2 signaling regulates cyclin D1 levels through the cAMP/PKA/ERK and PI3K /AKT/GSK3β pathways, and mediates the G1/S transition to control cell proliferation."

GPR176 is confirmed to activate the cAMP/PKA signaling pathway and modulate mitophagy, promoting CRC Mechanistically, the G protein GNAS is recruited intracellularly to transduce and amplify extracellular signals The GPR176/GNAS complex inhibits mitophagy via the cAMP/PKA/BNIP3L axis, thereby promoting the tumorigenesis in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

and Immunology Glucose and HODEs regulate Aspergillus ochraceus quorum sensing through the GprC-AcyA pathway Signals perception, transmission, and feedback are all rely on a signal network that constituted by membrane Here we show that the G protein-coupled receptor (GPCR) to cAMP pathway is responsible for transmitting pathway that in response to ligands glucose and HODEs are verified. These studies highlight a crucial G protein signaling pathway for cell communication that is mediated

Committee Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling Pathways Date & Time Friday, November 3rd / 11:55 AM About Catalina Ribas " Dr. During this period and her doctoral thesis, she has deepened the regulatory mechanisms of GPCR signaling complex (AGS, de “Activators of G-protein signaling). Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy

To explore the therapeutic potential of GPR132 signaling, we screened and validated a natural product target of rapamycin (mTOR), a regulator of AML cell differentiation blockade, via activating GPR132-Gs-PKA pathway. in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the pathway map of GPR56 as may be applicable in mesenchymal transition in GBM. , growth factors, and inflammation signaling pathways. We also considered intracellular and extracellular factors that may influence the activity of the pathway Raksha A Ganesh , Krishnan Venkataraman , Ravi Sirdeshmukh Tags GPR56 /ADGRG1 , Mesenchymal transition , Pathway

< GPCR News < GPCRs in Oncology and Immunology Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation Published date July 16, 2024 Abstract mutations, and our experiments confirmed oncogenic CysLT2R was impaired at activating the FAK/YAP/TAZ pathway our bioinformatic analysis uncovers a role for co-occurring mutations involving the plexin/semaphorin pathway , which has been shown capable of activating this pathway.

Registration Logo Contest Committee Sponsors GPCR Retreat Program < Back to schedule Targeting adenosine signaling for immuno-oncology Date & Time Friday, November 3rd / 4:35 PM Abstract "Adenosine (ADO) signaling through Potent inhibitors of ADO signaling are currently being tested in cancer patients, including in randomized I will present our recent work on adenosine-producing ectonucleotidases and adenosine signaling and discuss unexpected links between the adenosinergic pathway, DNA damage response and metabolic regulation."

Oncology and Immunology From outside to inside and back again: the lysophosphatidic acid-CCN axis in signal CCN proteins act to facilitate signaling events involving extracellular matrix proteins. The signaling pathways responsible for LPA/S1P-induced CCN1/2 typically involve activation of the small transduction pathways, contributing to the biphasic delayed responses typically seen in response to In this way, an extracellular signal (LPA or S1P) can activate GPCR-mediated intracellular signaling

< GPCR News < GPCRs in Oncology and Immunology GPR68-ATF4 signaling is a novel prosurvival pathway in hallmark of GBM is a highly acidic tumor microenvironment, which is thought to activate pro-tumorigenic pathways specific small molecule inhibitor of GPR68 named Ogremorphin (OGM) to induce the iron mediated cell death pathway To determine GPR68 inhibition's mechanism of cell death we use DAVID pathway analysis of RNAseq. Using our small molecule inhibitor OGM and genetic means, we show that blocking GPR68 signaling results

< GPCR News < GPCRs in Oncology and Immunology Chemoattractant receptor signaling in humoral immunity distinct sites on the receptor C termini, which dictates functional outcomes of β-arrestin-mediated signaling In this review, we summarize the current understanding of chemoattractant receptor signaling in the context in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Immunology A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling Here, we showed that US28 increased the malignancy of U251 glioblastoma cells by enhancing signaling mediated by sphingosine-1-phosphate (S1P), a bioactive lipid that stimulates oncogenic pathways in glioblastoma Inhibition of S1P signaling abrogated the proliferative and anti-apoptotic effects of US28. US28 also activated the S1P signaling axis in HCMV-infected cells.

GPCR News < GPCRs in Oncology and Immunology Orphan receptor GPR50 attenuates inflammation and insulin signaling These data suggest that GPR50 can attenuate inflammatory levels and regulate insulin signaling in adipocytes Furthermore, the effects are mediated through the regulation of the IRS1/AKT signaling pathway and PPAR-γ Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren Tags Diabetes mellitus type 2; GPR50; IRS1; Insulin signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology G protein-coupled receptor-mediated signaling of immunomodulation Here, we discuss the current understanding of the roles of GPCRs and their signaling pathways in tumor in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology The landscape of cancer-rewired GPCR signaling axes Published , cancer , cancer cell lines , cell-cell communication , drug repurposing , personalized medicine , signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Inhibition of Relaxin Autocrine Signaling Rottapel’s research interests lies in the elucidation of signal transduction pathways in cancer, immune observed in ovarian cancer and the identification of emergent vulnerabilities associated with adaptation pathways

and Immunology NPFF stimulates human ovarian cancer cell invasion by upregulating MMP-9 via ERK1/2 signaling Our results also showed that ERK1/2 signaling was activated in SKOV3 cells in response to the NPFF treatment In addition, blocking the activation of ERK1/2 signaling abolished the NPFF-induced MMP-9 expression pathway." in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology Context-dependent ciliary regulation of hedgehog pathway In the hedgehog pathway, bifunctional GLI transcription factors generate both GLI-activators (GLI-A) However, how these counterregulatory effectors coordinate cilia-regulated morphogenetic pathways is unclear Here we determined GLI-A/GLI-R requirements in phenotypes arising from lack of hedgehog pathway repression We studied hedgehog pathway repression by the GPCR GPR161, and the ankyrin repeat protein ANKMY2 that

< GPCR News < GPCRs in Oncology and Immunology Wnt pathway inhibition with the porcupine inhibitor LGK974 , suggesting that targeting the Gs-GPCR or components of the downstream signaling pathway could serve The Wnt signaling pathway has been implicated in the pathogenesis of FD-like bone, but the specific Wnts in a mouse model of Gs-GPCR pathway overactivation." Tania Moody, Ariane Zamarioli, Apsara Ram, Gauri Ganesh, Misun Kang, Sunita Ho, Edward C Hsiao Tags Wnt pathway

GPR97 depletion aggravates imiquimod-induced psoriasis pathogenesis via amplifying IL-23/IL-17 axis signal pathway Published date September 10, 2024 Abstract "Skin psoriasis is defined as receiving external This autoimmune loop in psoriasis pathogenesis is influenced by G protein-coupled receptor (GPCR) signalling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

< GPCR News < GPCRs in Oncology and Immunology DANGER Signals Activate G-Protein Receptor Kinases Suppressing Background: Injury mobilizes primitive 'DANGER signals' (DAMPs) activating innate immunocyte (neutrophils , PMN) signaling and function. Methods: We studied human and mouse PMN signaling elicited by mtDAMPs (GPCR surface expression; protein DAMPs suppress antimicrobial immunity via canonical GRK2 activation and a novel TLR-activated GRK2 pathway

< GPCR News < GPCRs in Oncology and Immunology Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling Published date June 21 G protein signaling (RGS) protein family modulators play essential role within regulating downstream signaling of GPCR receptors, with function in cancers unclear. study focused on the expression patterns of RGS proteins in CRC, identifying Regulator of G protein signaling

TIPE proteins control directed migration of human T cells by directing GPCR and lipid second messenger signaling our work describes a new mechanistic paradigm for how human T cells integrate GPCR and phospholipid signaling pathways to control directed migration. Goldsmith , Zienab Etwebi , Chin Nien Lee , Youhai H Chen , Honghong Sun Tags Directed migration , PI3K signaling in Oncology and Immunology Structural and molecular insights into GPCR function GPCR Activation and Signaling

Contest Committee Sponsors GPCR Retreat Program < Back to schedule Using food perception and bioamine signaling laboratory focuses on how organisms perceive and respond to environmental stress though cell non autonomous signaling mechanisms, and how these signals affect the health and longevity of the animal."