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receptor internalization "The internalization of G protein-coupled receptors (GPCRs) can be regulated by PKC However, most tools available to study the contribution of PKC isozymes have considerable limitations and characterized human embryonic kidney 293A (HEK293A) cell lines devoid of conventional or novel PKC Direct activation of PKC and mutation of rat mGlu5a Ser901, a PKC-dependent phosphorylation site in the , we present the PKC KO cell lines as more specific research tools to investigate PKC-mediated aspects

both GnIH peptides, and this stimulatory action was significantly reduced by two inhibitors of the PKC These data indicate that sea bass GnIHR signals can be transduced through the PKA and PKC pathways, and

biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC

and luciferase assays were performed to establish a potential signaling pathway of miR-19a/GRK6/GPCRs/PKC Results: We found that miR-19a, GPR39 mRNA and PKC mRNA were upregulated while GRK6 mRNA was downregulated identified that the over-expression of miR-19a could regulate the signaling between GRK6, GPR39 and PKC via the signaling pathway of miR-19a/GRK6/GPR39/PKC, which accordingly resulted in suppressed cell apoptosis

biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC Ma , He Zhang , Jiayan Fan , Hongyan Gao , Xinyu Xia , Wei Wu , Yuyuan Shi Tags GPCR , GRK6 , OSCC , PKC

Immunology Gi/o GPCRs drive the formation of actin-rich tunneling nanotubes in cancer cells via a Gβγ/PKCα signaling analysis reveals a strict requirement of phospholipase C β3 (PLCβ3) and its downstream effector PKCα