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October 2022 Coincident Regulation of PLCβ Signaling by Gq-Coupled and μOpioid Receptors Opposes Opioid Deletion of phospholipase Cβ3 (PLCβ3), or selective inhibition of Gβγ regulation of PLCβ3, enhances the Here we investigated a potential mechanism for regulation of PLC signaling downstream of MOR in HEK293 cells and found that MOR alone could not stimulate PLC, but rather required a coincident signal from Knockout of PLCβ3, or pharmacological inhibition of its upstream regulators, Gβγ or Gq, ex vivo in periaqueductal

M33 engages Gq/11 to constitutively activate phospholipase C β (PLCβ) and downstream cyclic AMP response-element Identification of a MCMV M33 mutant (M33ΔC38) for which CREB signalling was disabled, but PLCβ activation

receptor exclusively activated by designer drugs) hM3Dq, which activates [Ca2+]i signaling via the Gαq-PLCβ-IP3

in Neurodegenerative Disorders: Integrating Structural Biology and Drug Discovery Approaches Altered PLCβ

Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface.

epithelial proliferation, migration, and cellular respiration Spatiotemporal Optical Control of Gαq-PLCβ

September 2022 PLC-IP3-ORAI pathway participates in the activation of the MRGPRB2 receptor in mouse peritoneal increases in [Ca2+]i and voltage-dependent current caused by MRGPRB2 activation were blocked by U73122 (PLC Our results indicated the involvement of the PLC-IP3-ORAI signaling pathway and CACCS in MRGPRB2-mediated

modulation-based drug discovery and development, today announced that its collaboration agreement with Indivior PLC

September 2022 "The activation of phospholipase C (PLC) is thought to have a key role in the cardiomyocyte PLC activity results in the generation of diacylglycerol and inositol trisphosphate, which are downstream In this article, we describe the signal transduction elements that regulate PLC gene expression. α1-adrenoceptor signaling pathway and downstream signaling processes that mediate an upregulation of PLC Evidence is also indicated to demonstrate that PLC activities self-regulate the expression of PLC isozymes

MRGPRD was investigated further by probing downstream signaling effectors along the Gαq/Phospholipase C (PLC could be blocked by a Gαq inhibitor (YM-254890), an IKK complex inhibitor (IKK-16), and partly by a PLC

shots against the variant, the monoclonal antibody sotrovimab from Vir and partner GlaxoSmithKline PLC

constitutively active receptor linked to X-linked acrogigantism The mechanism of Gαq regulation of PLCβ3

addition, as an intermediary of G protein-coupled receptor (GPCR) signaling, the functions of ROCK and PLC

Update Septerna sells GPCR program to Vertex for $48 million Merck KGgA collaborates with Exscientia plc

receptor (TSHR) has been shown to regulate distinct cellular processes, including phospholipase C epsilon (PLCε