Diseases How biotech companies are using AI to design drugs GPCR Therapeutics Announces Publication in PNAS

Academy of Sciences of the United States of America, 100(19), 10782–10787. https://doi.org/10.1073/pnas

Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5391-3. doi: 10.1073/pnas.90.12.5391.

expression profiling has shown Remo expression in the central (CNS) and peripheral nervous systems (PNS In L3 PNS specimen Remo is expressed in a subset of neurons expressing the DEG/ENaC channel pickpocket

Neuromedin U , OSM , OSMRβ , Oncostatin M , Oncostatin-M specific receptor subunit beta , PAR2 , PC(20) , PN

identified DHEA, DHEAS and DOC are endogenous ligands of GPR64 etc (Nature, 2021a, Nat Chem Biol 2022, PNAS theory” etc. to explain the arrestin mediated GPCR functions (Nature communications, 2015, 2021, 2022; PNAS of fish oil (unsaturated fatty acids) and other lipids by GPCRs (Science 2023, Science Advance 2021, PNAS