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45 items found for "POTS"
- CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Diseases
< GPCR News < GPCRs in Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies This review highlights the potential as a therapeutic target of the CCR6 receptor in numerous diseases
- Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil chemoattractant
< GPCR News < GPCRs in Oncology and Immunology Chemokine Cxcl1-Cxcl2 heterodimer is a potent neutrophil Here, we characterized the role for heterodimer and show that the Cxcl1-Cxcl2 heterodimer is a potent
- S1P Signaling Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Drugs for Chronic Myeloid Leukemia
Genes as Prominent Drivers of BCR-ABL1-Independent Imatinib Resistance and Six Herbal Compounds as Potential Further, we identified interactors such as BIRC3, TRAF6, and SRC genes, with potential implications for Additionally, receiver operator characteristic curve analysis suggested these genes' potential as biomarkers compounds-ampelopsin, ellagic acid, colchicine, epigallocatechin-3-gallate, cucurbitacin B, and evodin-as potential
- Ep 137 with Dr. Josh Pottel
Josh Pottel About Dr. Josh Pottel "I lead Molecular Forecaster Inc. Josh Pottel on the web Molecular Forecaster LinkedIn BlueSky Google Scholar Twitter Dr.
- AGPCR 24 Session VII
neurotransmission Nicole Perry-Hauser GPR110 modulates anxiety-like behaviors and memory function in mice potentially GPCR GPR110 modulates anxiety-like behaviors and memory function in mice potentially through neuronal
- AGPCR 24 Session VIII
Additionally, the lab has begun to investigate potential roles for previously unrecognized cardiac-expressed
- AGPCR 24 Session V
This compact module provides a plethora of potential ligand binding sites for the various adhesion domains
- AGPCR 24 Session III
adapt this technology for high-throughput screening of pharmacological compound libraries to identify potential There, I investigated Two-Pore-Potassium channels using electrophysiology, molecular and chemical biology
- AGPCR 24 Student Flash Presentations
Since my undergraduate studies, I became fascinated with the class of adhesion GPCRs, owing to their potential
- Elucidation of active components and target mechanism in Jinqiancao granules for the treatment of prostatitis and benign prostatic hyperplasia
Aim of the study: We hypothesized that Jinqiancao granules could be a potential therapy for prostatitis work aimed to elucidate active compounds in Jinqiancao granules and their target mechanisms for the potential Three compounds showed potent GPR35 agonistic activity (EC50 < 10 μM) and the GPR35 agonism action of The findings provide scientific evidence for the potential use of Jinqiancao granules as a treatment
- Ep 144 with Dr Aurélien Rizk
They explored the potential of merging mathematical models with biology, the complexities of GPCRs within They found it fascinating to integrate both fields and the potential it holds. Dynamics Yamina Berchiche and Aurelien Rizk discussed the complexities of GPCRs within cells and the potential Company Aurelien Rizk and Yamina Berchiche discussed the founding of a company focused on GPCRs and the potential than GPCRs, to which Aurelien Rizk explained that they chose GPCRs due to their wide application and potential
- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
demonstrate an interplay between CXCR4 and HRH1, and suggest the possibility of the CXCR4-HRH1 heteromer as a potential
- Ep 126 with Dr. Françoise Bachelerie
which are commensal inhabiting the healthy human epithelium (virome) while presenting an oncogenic potential
- GPR4 in the pH-dependent migration of melanoma cells in the tumor microenvironment
in the tumor microenvironment Published date December 23, 2022 Abstract Due to its high metastatic potential Membrane-bound receptors, such as the proton-sensitive GPCR (pH-GPCR) GPR4, are considered as potential
- G protein-coupled receptors: A target for microbial metabolites and a mechanistic link to microbiome-immune-brain interactions
immune cells and the nervous system that are shown to hold much promise for clinical translational potential studies for an improved understanding of gut microbiota-immune-brain molecular interactions and their potential
- Systems modeling of oncogenic G-protein and GPCR signaling reveals unexpected differences in downstream pathway activation
One promising potential application of such mathematical models is the study of how disease-causing mutations Modeling the two major, mutually-exclusive, oncogenic mutations (Gαq/11 and CysLT2R) revealed the potential
- Ep 145 with Dr John Janetzko
applying for academic positions in the US, the importance of adaptability in one's career, and the potential John also discussed the potential complications that arose when his then-girlfriend, now wife, was applying
- Ep 148 with Dr Arthur Christopoulos
also explored the significance of translating fundamental discoveries into clinical applications, the potential hiring based on differentiation, impact, and interest, the need for workforce development, and the potential receptors for various diseases, with Arthur sharing insights on Eli Lilly's compound, Xanomeline, and the potential similar talk show format to 'Between Two Ferns', the importance of maintaining team culture, and the potential
- Ep 154 with Dr Badr Sokrat
scientists face in academia and industry, the importance of projection and careful communication, and the potential process and early tasks at Michelle’s lab, which involved creating stable cell lines and identifying potential Yamina emphasized the potential of multiplexing assays in expanding the scope of scientific exploration
- Ep 113 with Dr. Prasenjit Saha
This study demonstrated that PAG is a potential diagnostic marker for CVD as it causes serious fatal However, the pursuit of allosteric modulators has gained attention as they have the potential to fine-tune
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
Our findings suggest that the GNAI3 gene holds potential as a prognostic biomarker for GBM.
- G protein-coupled receptor-mediated signaling of immunomodulation in tumor progression
Therefore, GPCRs are potential targets for cancer immunotherapy.
- Regulation and role of mitochondria delta opioid receptors
Recently, his group reported the first in vivo GPCR interactome, revealing an important number of new potential
- Functional Assessment of Cancer-Linked Mutations in Sensitive Regions of Regulators of G Protein Signaling Predicted by Three-Dimensional Missense Tolerance Ratio Analysis
cause phenotypic changes that negatively impact GPCR-G protein signaling and suggests that 3DMTR is a potentially
- Opposite Effects of Src Family Kinases on YAP and ERK Activation in Pancreatic Cancer Cells: Implications for Targeted Therapy
Previously, we identified potent positive crosstalk between insulin/IGF-1 receptors and G protein-coupled A combination of dasatinib and trametinib potently and synergistically inhibited colony formation by
- Dr. GPCR Summit 2021 Live Talks
September 15, 2021 at 6:00:00 PM Learn More >> Hydroxycarboxylic acid receptor 3 and GPR84 signaling with potential
- The power of many: Multilevel targeting of representative chemokine and metabolite GPCRs in personalized cancer therapy
culminates by illuminating emerging therapies and discussing innovative strategies to harness the full potential
- Ep 147 with Dr. Demet Araç
Symposium to his team and encourage his students, postdocs, and PhD students to contact Yamina for potential addressed the naming conventions of proteins in the field, with Yamina expressing concern about the potential They also discussed the importance of the extracellular region of these receptors and its potential as upcoming Doctor GPCR Symposium in June, for which Demet is the first confirmed speaker, and discussed potential the future, with Yamina expressing her intention to reach out to Demet's students and postdocs for potential