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agonism is a phenomenon where different ligands acting on the same receptor trigger distinct signaling pathways Tirzepatide's success underscores the potential of designing drugs that selectively target beneficial signaling pathways By selectively targeting specific signaling pathways, it is possible to develop drugs with improved efficacy

Historically, drug discovery efforts targeting GPCRs focused on G-protein-dependent signaling pathways alongside the G-protein dependent pathways. ERK activation pathways can be categorised into two main sub-pathways based on their subcellular localisation Minireview: targeting GPCR activated ERK pathways for drug discovery. Spatiotemporal regulation of the p42/p44 MAPK pathway. Biology of the Cell, 93(1‐2), 71-79.

Learn about communication between GPCRs and PKA, Class F GPCR Smoothened & the Hedgehog signaling pathway

Sponsors GPCR Retreat Program < Back to schedule Unveiling Non-Canonical Functions for Gαq Signaling Pathways Ribas has characterized the existence of a new signaling pathway with a relevant role in cardiac hypertrophy

< GPCR News < GPCRs in Oncology and Immunology Context-dependent ciliary regulation of hedgehog pathway In the hedgehog pathway, bifunctional GLI transcription factors generate both GLI-activators (GLI-A) However, how these counterregulatory effectors coordinate cilia-regulated morphogenetic pathways is unclear Here we determined GLI-A/GLI-R requirements in phenotypes arising from lack of hedgehog pathway repression We studied hedgehog pathway repression by the GPCR GPR161, and the ankyrin repeat protein ANKMY2 that

< GPCR News < GPCRs in Oncology and Immunology GPR56 signaling pathway network and its dynamics in the mining of the molecular events plausibly associated with GPR56 activity, we have constructed a signaling pathway others associated with Wnt, integrin, calcium signaling, growth factors, and inflammation signaling pathways We also considered intracellular and extracellular factors that may influence the activity of the pathway Raksha A Ganesh , Krishnan Venkataraman , Ravi Sirdeshmukh Tags GPR56 /ADGRG1 , Mesenchymal transition , Pathway