Hern Wang Cheng , Arjandas Mahadev , Matthew Chau Hsien Ng , Michaela Su-Fern Seng , Prasad Iyer , Pei Ling Chia , Shui Yen Soh , Qi Zeng Tags PRL3 , PTP4A3 , PRL3-zumab , Wilms tumor , neuroblastoma , non-rhabdomyosarcoma

Furthermore, GPR50 knockout in the 3T3-L1 cell line suppressed PPAR-γ expression. Authors Zhenyu Yao, Jun Meng, Jing Long, Long Li, Weicong Qiu, Cairong Li, Jian V Zhang, Pei-Gen Ren

AGPCRs in the periphery ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Cheng-Chih disease Douglas Tilley ADGRG1/GPR56 regulates survival of terminally differentiated CD8+ T cells Cheng-Chih Hsiao Abstract Only available for AGPCR 24 Attendees Authors & Affiliations "Cheng-Chih Hsiao1,2, Hendrik Departments of Neurology and Immunology, Erasmus Medical Center, Rotterdam, The Netherlands" About Cheng-Chih Netherlands Institute for Neuroscience; 2022 - present: Researcher associate, Netherlands Brain Bank" Cheng-Chih

analyzed in HCC patients (gene expression omnibus database (GEO) (GSE45436)) and detected in HCC cell line and the results showed that GPR50 was significantly up-regulated in HCC patients and CBRH-7919 cell line Gpr50 cDNA was transfected into HCC cell line CBRH-7919, and we found that Gpr50 promoted the proliferation Authors Weiming Zhao , Lingling Xi , Guoying Yu , Gaiping Wang , Cuifang Chang Source Contribute to the

< GPCR News < GPCRs in Oncology and Immunology RGS20 promotes non-small cell lung carcinoma proliferation Background: Novel therapeutic targets are urgently needed for treating drug-resistant non-small cell lung Methods: Immunohistochemistry and lung cancer tissue microarray were used to verify the expression of Authors Xiaoyan Ding , Xiaoxia Li , Yanxia Jiang , Yujun Li , Hong Li , Lipeng Shang , Guilin Feng , Huhu Zhang , Ziyuan Xu , Lina Yang , Bing Li , Robert Chunhua Zhao Tags Autophagy , NSCLC , PKA-Hippo

Immunology [1,2,4]Triazolo[1,5-c]pyrimidines as Tools to Investigate A3 Adenosine Receptors in Cancer Cell Lines Compound 20 has been tested on both A3 adenosine receptor positive cancer cell lines (CHO-A3AR transfected , THP1 and HCCT26) and in A3 negative cancer cell lines, showing no effect on the latter and a proliferative Authors Stephanie Federico , Margherita Persico , Letizia Trevisan , Chiara Biasinutto , Giovanni Bolcato

< GPCR News < GPCRs in Oncology and Immunology A2aR on lung adenocarcinoma cells: A novel target for Here, we identify that A2aR is specifically expressed on tumor cells from lung adenocarcinoma (LUAD) Authors Ying Bai , Xin Zhang , Jiawei Zhou , Jianqiang Guo , Yafeng Liu , Chao Liang , Wenyang Wang , Yingru Xing , Jing Wu , Dong Hu . Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

Immunology Minireview: functional roles of tissue kallikrein, kinins, and kallikrein-related peptidases in lung Published date July 3, 2023 Abstract "Despite campaigns and improvements in detection and treatment, lung One approach to treating patients suffering from lung cancer is to target surface receptors overexpressed Since lung cancer is often diagnosed in advanced stages, our efforts should focus on early diagnosis, Furthermore, their modulation could be considered as a promising approach in lung cancer therapeutics

We probed CXCR4 and β2AR homo- and heteromultimerization in model cell lines and found that CXCR4 assembles multimeric complexes larger than dimers in MDA-MB-231 human breast cancer cells and in HCC4006 human lung Authors Junyi Liang , Mohamed Seghiri , Pradeep Kumar Singh , Hyeon Gyu Seo , Ji Yeong Lee , Yoonjung

Authors Jing Gao, Huiqing Liu, Yuxin Jin, Yunbo Luo, Kunlun Huang, Zhihong Liang Tags Cell communication

G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer Published date September 21, 2023 Abstract "Objectives: Lung cancer is a major public health protein-coupled receptor 37 (GPR37) exhibits unknown functions in tumors, particularly in non-small-cell lung We detected the expression of GPR37 in NSCLC tissues and cell lines. Authors Han Liu , Yingjie Zhu , Huikun Niu , Jing Jie , Shucheng Hua , Xiaoxue Bai , Shuai Wang , Lei

Authors Ahmad Raza , Meng-Chi Yen , Gangga Anuraga , Iram Shahzadi , Muhammad Waqar Mazhar , Hoang Dang Thi Minh Xuan , Sanskriti Dey , Sachin Kumar , Adrian Wangsawijaya Santoso , Bianca Tobias William , Chih-Yang

Oncology and Immunology G protein-coupled receptors: A target for microbial metabolites and a mechanistic link

Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7. , Wenyi Yu, Liangliang Zhou, Wenjie Yuan, Wanxian Wang, Yumin Yao, Jixia Wang, Yanfang Liu, Xinmiao Liang

< GPCR News < GPCRs in Oncology and Immunology Severity of neurological long-COVID symptoms correlates The pathogenesis of Long-COVID is currently under heavy scrutiny and existing data on the role of auto-immune moderate SARS-CoV-2 infection up to 12 months prior to enrollment with (n = 72) or without (n = 58) Long-COVID Results: The prevalence and concentrations of evaluated autoantibodes were significantly higher in Long-COVID significantly higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID

infiltration and predicts poor prognosis in ovarian cancer Published date August 15, 2023 Abstract "The long found to promote proliferation, migration, EMT, and apoptosis of ovarian cancer (OC) cells in OC cell lines QRT-PCR was used to validate the expression of PAXIP1-AS1 in OC cell lines. PAXIP1-AS1 was significantly downregulated in OC cell lines compared with IOSE29 cell line. Authors Buze Chen , Xiaoyuan Lu , Qingmei Zhou , Qing Chen , Siyan Zhu , Guilin Li , Hui Liu Source Contribute

Read More 11:30 AM Session VIII Physiological and pathological roles of AGPCRs in the periphery Cheng-Chih Andrew Dates Heterogeneity of Tethered Agonist Signaling in Adhesion G Protein-Coupled Receptors Cheng-Chih

News < GPCRs in Oncology and Immunology Regulator of G protein signaling protein 6 alleviates acute lung protein-coupled receptor (GPCR)-related genes and differentially expressed genes (DEGs) in an acute lung RGS6 plays a protective role in ALI not only in early inflammatory responses but also in endogenous lung Authors Juan Song , Miao Li , Cuicui Chen , Jian Zhou , Linlin Wang , Yu Yan , Jun She , Lin Tong , Yuanlin Song Tags Acute lung injury , Apoptosis , Cell-renewal , Inflammation , Regulator of G protein signaling

Authors Chakit Arora, Marin Matic, Luisa Bisceglia, Pierluigi Di Chiaro, Natalia De Oliveira Rosa, Francesco Guanming Wu, Gioacchino Natoli, J Silvio Gutkind , Francesco Raimondi Tags GPCR , cancer , cancer cell lines

< GPCR News < GPCRs in Oncology and Immunology Functional Assessment of Cancer-Linked Mutations in Sensitive Identified intolerant residues with reported cancer-linked mutations RGS14-R173C/H and RGS4-K125Q/E126K These findings show that 3DMTR identified intolerant residues that overlap with cancer-linked mutations : Human genetic variant/mutation information has expanded rapidly in recent years, including cancer-linked ratio (3DMTR) to define regions of genetic intolerance in RGS proteins and prioritize which cancer-linked

Hotel Carlota : An industrial chic experience at economical pricing. It can include breakfasts. 2.

hypoxia on migration, proliferation, invasion, and signaling in 2D and 3D models of breast cancer cell lines There were some discrepancies in the responses of each cell line to the isoform-specific antagonists

Usage of Lorazepam, which has off target agonism of GPR68, is linked to worse clinical outcomes for a titer glo, were used to demonstrate sensitivity to GPR68 inhibition in twelve immortalized and PDX GBM lines we show that blocking GPR68 signaling results in robust cell death in all thirteen glioblastoma cell lines We use U87 and U138 glioblastoma cell lines to show how selective induction of ferroptosis occurs in

nutrient availability, by inhibiting genes involved in gamete recognition. " Authors & Affiliations "King I am currently finishing my postoc in the laboratory of Pr Nicole King at UC Berkeley where I am studying Alain Garcia De Las Bayonas on the web King Lab Critical role for CD97/ADGRE5 in the induction of allergic

characterise the molecular pharmacology of GPR146 and to validate the proposed ligands of GPR146 in line

that CXCR4 forms heteromers with LPA1 in recombinant HEK293A cells and the human breast cancer cell line LPA1 heteromers on CXCL12-induced signaling and cell migration have been evidenced across various cell lines

Holliday After an undergraduate degree at the University of Cambridge, Nick carried out his Ph.D. at King

She received her BSc in Human Biology from King’s College London in 1997, and while her Ph.D. commenced