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49 items found for "Peng Yang"
- Regulators of G-protein signaling: essential players in GPCR signaling
In addition to the RGS domain, RGS proteins also contain a range of other structural motifs that are : Recent studies have revealed that the interaction between RGS proteins and GPCRs is mediated by a range of RGS protein dysregulation in disease: The Dysregulation of RGS proteins has been implicated in a range The dysregulation of these proteins has been implicated in a range of diseases, and understanding the Wang, Q., L.Y. Liu-Chen, and J.R.
- Artificial intelligence – faster, smarter, cheaper GPCR drug discovery
to predict subtype-selective ligands for dopamine receptors and adenosine receptors (He, Ben, Kuang, Wang & Kong, 2016; Kuang, Feng, Hu, Wang, He & Kong, 2016). 5.
- Chemokine receptor-targeted drug discovery: progress and challenges
The chemokine receptor system is implicated in a wide range of inflammatory, autoimmune and infectious binding, as well as G-protein coupling or interaction with other signaling molecules (Sohy et al. 2009; Wang protein-protein interactions which are difficult to modulate using small molecules (Sohy et al. 2009; Wang
- Therapeutic validation of an orphan G protein-coupled receptor: The case of GPR84
August 2022 "Despite the importance of members of the GPCR superfamily as targets of a broad range of Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings
- Therapeutic validation of an orphan G protein‐coupled receptor
Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders indole‐3‐carbinol, which is present at high levels in some vegetables including broccoli and kale (Wang
- Discovery On Target, October 17-20, 2022, Boston, USA
well as target validation strategies for the discovery and development of novel therapeutic agents ranging
- Obesity-induced changes in human islet G protein-coupled receptor expression: Implications for ...
this review, we have compared expression of GPCR mRNAs in human islets obtained from normal weight range donors, and those with a weight range classified as obese.
- ShouTi Introduces Basecamp Bio as a Wholly Owned Subsidiary to Expand Pipeline and Partnerships
clinical-stage global biopharmaceutical company developing novel oral therapeutics to treat a wide range
- Crinetics Pharmaceuticals announced the formation of an independently operated new company...
develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range develop a deep pipeline of novel, targeted, nonpeptide radiopharmaceuticals for the treatment of a broad range
- MSX-122: Is an effective small molecule CXCR4 antagonist in cancer therapy?
cytokines along with their receptors, are involved in various biologic processes and regulation of a wide range
- Verily links up with Sosei Heptares for GPCR drug discovery
recent years as researchers have discovered the vast potential for GPCR-targeting drugs in treating a range
- G protein-coupled receptor signaling: transducers and effectors
"G protein-coupled receptors (GPCRs) are of considerable interest due to their importance in a wide range
- G protein-coupled receptor kinase type 2 and β-arrestin2: Key players in immune cell functions...
GRK2/β-arrestin2 play multiple roles in the pathological mechanisms of a wide range of diseases including
- Cancer Research UK and Sosei Heptares sign agreement to advance cancer immunotherapy candidate ...
candidate into clinical trials " HTL0039732 is a novel EP4 antagonist with potential to treat a wide range
- Decoding β-Arrestins: from Structure to function
detection, receptor activation initiates conformational changes, exposing an intracellular cavity (Kang Despite multifocal signaling, recent studies indicate that signaling occurs within a 100 nm range from high-resolution protein structures, illuminating side chain orientations and overall conformational states (Kang
- AlphaFold2 versus experimental structures: evaluation on G protein-coupled receptors
August 2022 "As important drug targets, G protein-coupled receptors (GPCRs) play pivotal roles in a wide range
- Hear the sounds: the role of G protein-coupled receptors in the cochlea
G protein-coupled receptors (GPCRs) are crucial receptors that regulate a wide range of physiological
- Fluorescent Ligands Targeting Intracellular Allosteric Binding Site of the Chemokine Receptor CCR2
ligands are versatile molecular tools to study G protein-coupled receptors (GPCRs) and can be used for a range
- Immunomodulatory Role of Neuropeptides in the Cornea
Corneal nerves produce various neuropeptides that have a wide range of functions on immune cells.
- β-arrestin1 and 2 exhibit distinct phosphorylation-dependent conformations when coupling to the...
associate with the active parathyroid hormone 1 receptor (PTH1R) in different complex configurations ("hanging
- Accelerating GPCR Drug Discovery With Conformation-Stabilizing VHHs
GPCRs respond to a wide variety of signals that range in size from photons to proteins (Foord et al.,
- In vivo detection of GPCR-dependent signaling using fiber photometry and FRET-based biosensors
Hence, it has wide applicability across a spectrum of neuroscience research, ranging from the study of
- Newly launched antibody libraries put hard-to-drug targets within reach
The drugs also target relatively low-hanging fruit: like cytokines or tyrosine kinase receptors.
- Cholesterol-Dependent Dynamics of the Serotonin 1A Receptor Utilizing Single Particle Tracking....
2022 "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range
- Cholesterol-Dependent Dynamics of the Serotonin1A Receptor Utilizing Single Particle Tracking: ...
Modes "G protein-coupled receptors (GPCRs) are signaling hubs in cell membranes that regulate a wide range
- Targeted Therapies to Reduce Side Effects in Modern Drug Development
Modern drug development approaches include a range of techniques leveraging structural biology, immunology
- Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5
fragment- and seven lead-like compounds were confirmed to bind to the allosteric site with affinities ranging
- Successful prednisolone or calcimimetic treatment of acquired hypocalciuric hypercalcemia caused...
diseases, (d) showed spontaneously fluctuating Ca levels from approximately normal to near fatally high ranges