December 2021 "Meet Peter McNamara , Ph.D., Tectonic ’s SVP, Head of Research. Peter joined Tectonic to help chart new territory in GPCR science. We’re glad to have Peter's dedication, experience, and passion in building innovative therapeutics."

Peter Banks, Scientific Director at BioTek Instruments! Learn about his career today!

Bryan Roth, Peter Gmeiner, and Thomas P. Sakmar this week. For Dr.

and antihistamines: A clinical trial is needed Jillian G Baker ,  Erica K Sloan ,   Kevin Pfleger ,  Peter at two distinct sites of a human bitter taste GPCR Lior Peri ,  Donna Matzov ,  Dominic R Huxley ,   Peter Gmeiner ,  Peter J McCormick ,  Dorothee Weikert ,  Masha Y Niv ,  Moran Shalev-Benami , et al.

consequences of spatial, temporal and ligand bias of G protein-coupled receptors Antonios Drakopoulos , Peter Gmeiner , Davide Calebiro , Michael Decker , et al. for their study on Design, Synthesis, and Characterization

This week's highlight includes congrats to: Makaía M Papasergi-Scott, Peter Gmeiner, Brian K Kobilka,

their study on Frizzleds act as dynamic pharmacological entities Marina Casiraghi, Robert J Lefkowitz, Peter Gmeiner, Brian K Kobilka et al. for their investigation on Molecular insights into G protein coupling Reviews, GPCRs, and more The GLP-1R as a model for understanding and exploiting biased agonism in next-generation

Significantly, we show that GRKs generate distinct phosphorylation barcodes in intracellular loop 2 ( regulate recruitment of the scaffolding protein β-arrestin 2 (βarr2) to APH1A and γ-secretase-mediated Aβ generation the molecular and structural determinants of the APH1A-βarr2 interaction that critically regulate Aβ generation

September 2022 "Chemerin is the product of the RARRES2 gene which is secreted as a precursor of 143 amino acids. That precursor is inactive, but proteases from the coagulation and fibrinolytic cascades, as well as from inflammatory reactions, process the C-terminus of chemerin to first activate it and then subsequently inactivate it. Chemerin can signal via two G protein-coupled receptors, chem1 and chem2, as well as be bound to a third non-signaling receptor, CCRL2. Chemerin is produced by the liver and secreted into the circulation as a precursor, but it is also expressed in some tissues where it can be activated locally. This review discusses the specific tissue expression of the components of the chemerin system, and the role of different proteases in regulating the activation and inactivation of chemerin. Methods of identifying and determining the levels of different chemerin forms in both mass and activity assays are reviewed. The levels of chemerin in circulation are correlated with certain disease conditions, such as patients with obesity or diabetes, leading to the possibility of using chemerin as a biomarker." Read more at the source #DrGPCR #GPCR #IndustryNews

G-Protein Coupled Receptors), today announced the promotion of Senior Vice President, Head of Research, Peter

his article Class B1 GPCR Dimerization: Unveiling Its Role in Receptor Function and Signaling Sonja Peter transepithelial dendrite formation in human intestinal dendritic cells Methods & Updates in GPCR Research Generation

It provided a fundamental understanding of how genetic information is stored and transferred between generations Advances in genomic technologies, such as genome-wide association studies and next-generation sequencing B., Panova, O., Hilger, D., Casiraghi, M., He, F., Maul, L., Gmeiner, P., Kobilka, B.

Small size and solubility: Their small size and soluble nature make them ideal building blocks for generating Generation, selection and functional expression: Nanobodies can be obtained by immunizing a camelid and Nanobodies: A Review of Generation, Diagnostics and Therapeutics. C., Gmeiner, P., Steyaert, J., Weis, W. I., Garcia, K. C., Wess, J., & Kobilka, B. K. (2013).