Search Results
68 items found for "Peter J P Croucher"
- Spliceosome mutations are associated with clinical response in a phase 1b/2 study of the PLK1 inhibitor onvansertib in combination with decitabine in relapsed or refractory acute myeloid leukemia
Authors Peter J P Croucher , Maya Ridinger , Pamela S Becker , Tara L Lin , Sandra L Silberman , Eunice
- Ep 57 with Dr. Peter Robert Banks
Peter Robert Banks About Dr. Peter Robert Banks Peter Banks is currently the Scientific Director at BioTek Instruments , now a part Peter Robert Banks on the web LinkedIn Dr.
- Ep 06 with Dr. J. Silvio Gutkind
J. Silvio Gutkind About this episode Dr. J. J. J. J Silvio Gutkind on LinkedIn Gutkind Lab on Twitter UCSD Moores Cancer Center Dr.
- Ep 03 with Dr. J. Silvio Gutkind
J. Silvio Gutkind About this episode Have you had moments that defined your scientific tastes? J Silvio Gutkind, a class on oncogenes and his interests for GPCRs helped shape his scientific interests J. Silvio Gutkind on the web Dr. J Silvio Gutkind on LinkedIn Gutkind Lab – UC San Diego Moores Cancer Center Gutkind Lab publications
- Ep 59 with Dr. Nicola J. Smith
Nicola J. Smith About Dr. Nicola J. Smith Dr. Nicola J Smith is an expert in molecular pharmacology with a track record in exploring GPCR structure-function Nicola J. Smith on the web UNSW Sydney LinkedIn Retraction Watch Twitter Dr.
- Ep 115 with Dr. Paul J. Gasser
Paul J. Gasser About Dr. Paul J. Paul J.
- Ep 27 with Dr. Robert J. Lefkowitz
Robert J. Well, it’s the one and only Robert J. Robert J.
- Ep 140 with Dr Alix A J Rouault
J. Rouault About Dr. Alix A. J. reviewed the literature on the melanocortin receptor accessory protein 2 (MRAP2), resulting in my first peer-reviewed I am hopeful that my efforts to support the professional opportunities of my peers, in combination with J.
- Ep 50 with Dr. Thomas P. Sakmar
Thomas P. Sakmar About Dr. Thomas P. Thomas P.
- Comparison of infectious complications with BCMA-directed therapies in multiple myeloma
= 0.004) and time to severe infection (HR 2.04, 1.05-3.96, P = 0.036) than their CAR-T counterparts. During periods of non-neutropenia, CAR-T recipients had a lower risk (HR 0.44, 95%CI 0.21-0.93, P = 0.032 ) and incidence rate (IRR:0.32, 95% 0.17-0.59, P < 0.001) of severe infections than BsAb. Nemirovsky, Andriy Derkach, Bruno Almeida Costa, Noriko Nishimura, Tasmin Farzana, Colin Rueda, David J Chung, Heather J Landau, Oscar B Lahoud, Michael Scordo, Gunjan L Shah, Hani Hassoun, Kylee Maclachlan
- Structure-based discovery of functionally selective 5-HT1A receptor agonists
selective 5-HT1A receptor agonists Date & Time Saturday, November 4th / 9:05 AM Abstract Coming Soon About Peter Peter Gmeiner received his Ph.D. from the University of Munich. Peter has been chaired Full Professor of Pharmaceutical / Medicinal Chemistry at the Friedrich-Alexander Peter Gmeiner has been spokesman of the Research Training Group "Medicinal Chemistry of Selective GPCR Ligands" (GRK 1910). " Peter Gmeiner on the web Friedrich Alexander University Erlangen-Nürnberg Pubmed
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
Authors Nick D Bergkamp , Jeffrey R van Senten , Hendrik J Brink , Maarten P Bebelman , Jelle van den Bor , Tuğçe S Çobanoğlu , Kasper Dinkla , Johannes Köster , Gunnar Klau , Marco Siderius , Martine J
- Pancreatic ductal adenocarcinoma, β-blockers and antihistamines: A clinical trial is needed
Authors Jillian G Baker, Erica K Sloan, Kevin Pfleger, Peter J McCormick, Cristina Salmerón, Paul A Insel
- Purinergic GPCR-integrin interactions drive pancreatic cancer cell invasion
Carter , Nicolas Jaime Roth , Jessica Gibson , Ariana Samadi , Hemant M Kocher , Sabrina Simoncelli , Peter J McCormick , Richard Philip Grose Tags cancer biology , cell biology , human.
- The GPCR-Gαs-PKA signaling axis promotes T cell dysfunction and cancer immunotherapy failure
Bryan S Yung , Farhoud Faraji , Robert Saddawi-Konefka , Zhiyong Wang , Alexander T Wenzel , Miranda J Rebecca Berdeaux , Dario A A Vignali , Ramiro Iglesias-Bartolome , Hannah Carter , Eytan Ruppin , Jill P Mesirov , J Silvio Gutkind .
- Biochemical pharmacology of adenylyl cyclases in cancer
Authors Bikash Chandra Jena, Daniel P Flaherty, Valerie P O'Brien, Val J Watts Tags Adenylyl Cyclase
- The Effect of Cancer-Associated Mutations on Ligand Binding and Receptor Function - A Case for the 5-HT2C Receptor
Chenlin Feng, Rongfang Liu, Reno Brooks, Xuesong Wang, Willem Jespers, Marina Gorostiola González, Gerard J P van Westen, Erik H J Danen, Laura H Heitman Tags 5-HT(2C) receptor , G protein-coupled receptor , cancer
- The GPCR adaptor protein Norbin controls the trafficking of C5aR1 and CXCR4 in mouse neutrophils
Authors Stephen A Chetwynd, Richard J Ward, Graeme Milligan, Heidi C E Welch Tags C5aR1 , CXCR4 , G protein-coupled receptor (GPCR) , GPCR trafficking , Ncdn , Neurochondrin , P-Rex1 , agonist-induced internalisation
- G Proteins and GPCRs in Cancer: Novel Precision Targeted and Immunotherapies
Targeted and Immunotherapies Date & Time Friday, November 3rd / 3:30 PM Abstract Coming Soon About J. J.
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
higher in the case group as compared to the control group (positivity 40.31 ± 3.01 vs. 20.46 ± 1.93, p < 0.001; density 2.77 ± 1.17 vs. 1.28 ± 0.37, p < 0.001). mRNA level was also upregulated in patients compared to the controls (2.36 ± 1.30 vs. 1.09 ± 0.42, p < 0.001) and showed a positive correlation with immunostaining of protein in OSCC (r = 0.48, p = 0.011 differentiation (p = 0.013), clinical TNM stages (p = 0.014), and poor survival (p = 0.006) of patients
- Ep 88 with Dr. Hannes Schihada
By the end of 2021, I moved back to Germany and joined the pharmaceutical chemistry group of Peter Kolb
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
Low PAXIP1-AS1 expression in OC was associated with age (P = 0.045), histological grade (P = 0.011), and lymphatic invasion (P = 0.004). Low PAXIP1-AS1 expression predicted a poorer overall survival (OS) (HR: 0.71; 95% CI: 0.55-0.92; P = survival (DSS) (HR: 0.67; 95% CI: 0.51-0.89; P = 0.006). PAXIP1-AS1 expression (HR: 0.711; 95% CI: 0.542-0.934; P = 0.014) was independently correlated with PFS
- Mutation Patterns Predict Drug Sensitivity in Acute Myeloid Leukemia
Authors Guangrong Qin, Jin Dai, Sylvia Chien, Timothy J Martins, Brenda Loera, Quy H Nguyen, Melanie L Oakes, Bahar Tercan, Boris Aguilar, Lauren Hagen, Jeannine McCune, Richard Gelinas, Raymond J Monnat
- Session V | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Seufert2, Yin Kwan Chung3, Daniela Volke1, Ralf Hoffmann1, Torsten Schöneberg4, Tobias Langenhan3, Peter Authors & Affiliations "Garbett, Krassimira, Kordon, Szymon P., Shearer, Tanner, Sando, Richard C.*, Chung, Yin Kwan2, Pohl, Fabian2, Batebi, Hossein1 Sträter, Norbert3 , Langenhan, Tobias2 & Hildebrand, Peter
- Receptor autoantibodies: Associations with cardiac markers, histology, and function in human non-ischaemic heart failure
β1 AR) , M5-muscarinic (M5AR), and angiotensin II type 2 receptors (AT2R) were increased in HF (all P against α1 -adrenergic (α1 AR) and angiotensin II type 1 receptors (AT1R) were decreased in HF (all P < 0.05) and global longitudinal strain (r = -0.323, P < 0.05). In insulin-resistant HF patients, AT2R autoantibodies were decreased (r = -.240, P < 0.05), and AT1R autoantibodies were increased (r = 0.212, P < 0.05).
- [Inhibitory effect of downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory response in human gingival fibroblasts]
to promote the expressions of GPRC5A compared with those of the NC group (1.00±0.01, 1.00±0.00)(all P< increase of GPRC5A at both gene and protein levels induced by LPS (1.30±0.10, 1.43±0.03) (F=208.38, P< 0.001; F=42.04, P<0.001). PTGS2 at the gene level in LPS group were highly increased compared with those in the NC group (all P< in the NC group, and siGPRC5A could effectively suppressed LPS-induced protein phosphorylation (all P<
- Severity of neurological long-COVID symptoms correlates with increased level of autoantibodies targeting vasoregulatory and autonomic nervous system receptors
of evaluated autoantibodes were significantly higher in Long-COVID compared to the 2 other groups (p higher number of patients with simultaneous detection of more than one autoantibody in Long-COVID group (p ARB1 and ARB2 correlated negatively CERAD Trail Marking A and B (R ≤ -0.26, p ≤ 0.043), while CHRM3 correlated positively with Chadler Fatigue Scale (R = 0.37, p = 0.0087).
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
patients receiving CLAG-M/sorafenib at RP2D (OS: hazard ratio,0.24 [95% confidence interval, 0.07-0.82]; P = .023; EFS: hazard ratio, 0.16 [95% confidence interval, 0.05-0.53]; P = .003). Benefit was limited to patients with intermediate-risk disease (univariate analysis: P = .01 for OS; P = .02 for EFS).