September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to Research over the past years has provided a substantial body of evidence demonstrating that platelets The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release In particular, platelets can activate neutrophils to form neutrophil extracellular traps (NETs).

September 2022 "Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet Data on platelet activation are extrapolated across experimental settings. C1-inhibitor (C1INH) is a protease inhibitor present in plasma but not in isolated platelet suspensions Here we show that C1INH affects platelet activation through PAR1 and PAR4 agonists. The platelet suspensions were exposed to PAR1 agonists SFLLRN, TFLLR and TFLLRN; PAR4 agonists AYPGKF

under Shear "Glycoprotein (GP)VI and integrin αIIbβ3 are key signaling receptors in collagen-dependent platelet PTK2 inhibition or of pGRP with pCIB > pCIBm in additive ways suppressed collagen- and GPVI-dependent platelet

for the 33 adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor that senses collagen and shear force to initiate the platelet activation program.

These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute

Judith Graham Poole postdoctoral fellow to work on the role of cytoskeletal proteins in megakaryocyte to platelet