Hansen et a l has introduced a sensitive method for detecting GPCR mRNAs in human immune cells and platelets reports that human white blood cells express an average of 160 GPCR mRNAs, ranging from 123 to 206, while platelets Therefore this study significantly advances our understanding of GPCR expression in human immune cells and platelets

September 2022 "Platelets are well characterized for their indispensable role in primary hemostasis to Research over the past years has provided a substantial body of evidence demonstrating that platelets The surface expression of pattern recognition receptors, such as TLR2 and TLR4, provides platelets with Platelet α-granules contain microbicidal proteins, chemokines and growth factors, which upon release In particular, platelets can activate neutrophils to form neutrophil extracellular traps (NETs).

September 2022 "Introduction Protease activated receptors 1 (PAR1) and 4 (PAR4) agonists are used to study platelet Data on platelet activation are extrapolated across experimental settings. C1-inhibitor (C1INH) is a protease inhibitor present in plasma but not in isolated platelet suspensions Here we show that C1INH affects platelet activation through PAR1 and PAR4 agonists. The platelet suspensions were exposed to PAR1 agonists SFLLRN, TFLLR and TFLLRN; PAR4 agonists AYPGKF

< GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells and platelets macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets Platelets made 69. Some, but far from all, of the receptors we found have been detected earlier.

receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis Authors Yanni Xi, Zhenya Min, Mianxue Liu, Xueqin Li, Zhao-Hua Yuan Tags P2Y12R , P2Y12R inhibitors , Platelets

for the 33 adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor that senses collagen and shear force to initiate the platelet activation program.