< GPCRs in Oncology and Immunology G protein coupled receptor transcripts in human immune cells and platelets macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets Platelets made 69. Some, but far from all, of the receptors we found have been detected earlier.

receptor (P2Y12R) is an adenosine-activated G protein-coupled receptor (GPCR) that plays a central role in platelet P2Y12R activation can promote platelet aggregation and adhesion to cancer cells, promote tumor angiogenesis Authors Yanni Xi, Zhenya Min, Mianxue Liu, Xueqin Li, Zhao-Hua Yuan Tags P2Y12R , P2Y12R inhibitors , Platelets

for the 33 adhesion GPCRs in complex physiological contexts…one being our discovery that GPR56 is the platelet receptor that senses collagen and shear force to initiate the platelet activation program.

These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute

Judith Graham Poole postdoctoral fellow to work on the role of cytoskeletal proteins in megakaryocyte to platelet