Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium

adhesion GPCR that traffics with Dlg1 to the basolateral membrane and regulates epithelial apicobasal polarity GPR125 (ADGRA3), an orphan adhesion GPCR, has been shown to modulate planar cell polarity in gastrulating Furthermore, in polarized MDCK cells, GPR125 is exclusively recruited to the basolateral domain of the likely requires the C-terminal PDZ-domain-binding motif of GPR125 and its interaction with the cell polarity basolateral protein GPR125, an autocleavable adhesion GPCR, appears to play a crucial role in apicobasal polarization

macrophages through enhancing NLRP3 inflammasome activation, while the loss of GPR84 prevents the M1 polarization CLH536, a novel GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and

Immunology A GPCR-neuropeptide axis dampens hyperactive neutrophils by promoting an alternative-like polarization Specifically, the Mrgpra1-NPFF axis counter-regulated interferon (IFN) γ-mediated neutrophil polarization during acute lung infection by favoring an alternative-like polarization, suggesting that it may act Lajoie , Xinzhong Dong Tags IFNγ , Mrgpra1 GPCR , NPFF , lung infection , neuropeptide FF , neutrophil polarization

LUAD mice, we find that A2aR highly expressed on LUAD cells promotes the secretion of chemokines and polarizing Notably, the M2 polarization of TAMs can also be prevented by inhibiting A2aR in vitro. Together, our studies demonstrate that A2aR on LUAD cells drives TAMs migration and polarization, and Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

February 13, 2024 Abstract "Neutrophils are heterogeneous, but the mechanisms underlying their ability to polarize the GPCR Mrgpra1 and the neuropeptide NPFF, molecules involved in pain and itch, direct neutrophil polarization