GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and function of pro-inflammatory macrophages.

August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment " Background: Inflammatory microenvironment promotes odontoblastic differentiation this study, we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the inflammatory Methods: Microarray analysis was performed to explore the differential mRNA profiles in inflammatory

September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL inflammatory diseases. autophagy‐enhancing agent, trehalose, or related sugar compounds, and the underlying mechanism focusing on macrophage Methods We investigated the therapeutic effects of trehalose and saccharin on macrophage IL‐1β production

Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local

differentially regulate signaling by the receptors CCR1 and CCR5 Published date November 23, 2023 Abstract "Inflammatory chemokines are often elevated in disease settings, where the largest group of CC-chemokines are the macrophage inflammatory proteins (MIP), which are promiscuous for the receptors CCR1 and CCR5.

inflammation and tissue injury via prosaposin-GPR37 signaling Published date July 11, 2023 Abstract "Macrophages We report that efferocyte-derived EVs express prosaposin, which binds to macrophage GPR37 to increase efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase in lesional macrophage Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage Subramanian Tags CP: Immunology , GPCR , atherosclerosis , efferocytosis , inflammation resolution , macrophage