GPR84 signaling promotes intestinal mucosal inflammation via enhancing NLRP3 inflammasome activation in macrophages Infiltrating GPR84+ macrophages are significantly increased in the colonic mucosa of both the UC patients GPR84 activation imposes pro-inflammatory properties in colonic macrophages through enhancing NLRP3 inflammasome GPR84 antagonist discovered by us, suppresses colitis by reducing the polarization and function of pro-inflammatory macrophages.

August 2022 TAS2R supports odontoblastic differentiation of human dental pulp stem cells in the inflammatory microenvironment " Background: Inflammatory microenvironment promotes odontoblastic differentiation this study, we aimed to explore the role of TAS2R in odontoblastic differentiation of hDPSCs in the inflammatory Methods: Microarray analysis was performed to explore the differential mRNA profiles in inflammatory

September 2022 Sweet taste receptor agonists attenuate macrophage IL‐1β expression and eosinophilic inflammation Autophagy deficiency in myeloid cells plays a causal role in eosinophilic CRS (ECRS) via macrophage IL inflammatory diseases. autophagy‐enhancing agent, trehalose, or related sugar compounds, and the underlying mechanism focusing on macrophage Methods We investigated the therapeutic effects of trehalose and saccharin on macrophage IL‐1β production

GPR21 couples to the Gq family of G proteins and is expressed in macrophages. Studies of GPR21 knock-out mice indicated that GPR21 may be involved in promoting macrophage migration The aim of this study was to evaluate the role of GPR21 in human macrophages, analyzing (i) its involvement THP-1 cells were activated and differentiated into either M1 or M2 macrophages. Cell migration was detected by the Boyden chamber migration assay, performed on macrophages derived from

September 2022 Dynamics of tumor-associated macrophages in a quantitative systems pharmacology model As tumor-associated macrophages (TAMs) serve as major contributors to the immuno-suppressive tumor microenvironment We show that through proper calibration, the model captures the macrophage heterogeneity in the tumor

September 2022 High GPER expression in triple-negative breast cancer is linked to pro-metastatic pathways Transcriptome-based bioinformatics analysis revealed that GPER was linked to pro-metastatic pathways

expression has been directly challenged by a publication purporting ACKR1 expression in mouse BM by macrophages , but not erythroblasts and ECs, suggesting that macrophage ACKR1 engages its non-cognate ligand CD82 The reported ACKR1 expression by macrophages in Hur et al. relied on using commercial anti-ACKR1 antibody prompted us to investigate the specificity of FAB6695 and scrutinize the apparent ACKR1 expression in BM macrophages

August 2022 "The calcium-permeable cation channel TRPM3 can be activated by heat and the endogenous steroid pregnenolone sulfate. TRPM3's best understood function is its role as a peripheral noxious heat sensor in mice. However, the channel is expressed in various tissues and cell types including neurons as well as glial and epithelial cells. TRPM3 expression patterns differ between species and change during development. Furthermore, a plethora of TRPM3 variants that result from alternative splicing have been identified and the majority of these isoforms are yet to be characterized. Moreover, the mechanisms underlying regulation of TRPM3 are largely unexplored. In addition, a micro-RNA gene (miR-204) is located within the TRPM3 gene. This complexity makes it difficult to obtain a clear picture of TRPM3 characteristics. However, a clear picture is needed to unravel TRPM3's full potential as experimental tool, diagnostic marker and therapeutic target. Therefore, the newest data related to TRPM3 have to be discussed and to be put in context as soon as possible to be up-to-date and to accelerate the translation from bench to bedside. The aim of this review is to highlight recent results and developments with particular focus on findings from studies involving ocular tissues and cells or peripheral neurons of rodents and humans." Read more at the source #DrGPCR #GPCR #IndustryNews

Both groups of metabolites suppress anti-inflammatory interleukin-10 signaling in human macrophage cell types, but they also suppress the pro-inflammatory interleukin-17A+ population in TH 17-differentiated

For instance, the expression of specific chemokine receptors in monocytes and macrophages indicates their involvement in immune cell trafficking and inflammatory responses. previous studies, notably the work by Groot-Kormelink et al., which reported 165 GPCR mRNAs in alveolar macrophages contributions.Moreover, the study's findings on the unique expression of chemokine receptors in monocytes and macrophages suggest that these GPCRs could be targeted to modulate inflammatory responses, offering potential therapeutic

Past work has produced conflicting results with respect to the effects of pro-inflammatory conditions Thus, we systematically investigated the relationship between the concentration of two distinct pro-inflammatory respect to inhibition of microglia nitric oxide release is dependent on the concentration and type of pro-inflammatory This indicates that different pro-inflammatory stimuli influence the capacity of microglia to synthesize

constitute an important biochemical axis that influence many cellular pathways involving homeostatic and inflammatory participate in the activation, chemotaxis and recruitment of multiple immunological cells such as microglia, macrophages multiple sclerosis, in the recovery from central nervous system injuries, in several chronic, peripheral inflammatory

Highly Dynamic during Collagen-Induced Arthritis "The sympathetic nervous system (SNS) has either a pro-inflammatory or anti-inflammatory effect, depending on the stage of arthritis. expression and signaling during sustained inflammation might be an integral part of the switch from pro - to anti-inflammatory action of sympathetic mechanisms in late arthritis."

GPR84 has been shown to be an attractive target in pro‐inflammatory conditions (Gagnon et al., 2018; Regarding the first question, GPR84 overexpression in immune cells in a range of pro‐inflammatory disorders renders it a promising target in inflammatory and fibrotic conditions, including neuroinflammation ( GPR84 has been additionally proposed to be a potential biomarker in different inflammatory diseases (

NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists "In order to avoid a prolonged pro-inflammatory

β-Alanine-Mediated Activation of the Human Mas-Related G Protein-Coupled Receptor D Induces Release of the Inflammatory Several members of MRGPRs are also expressed in mast cells, macrophages, and in cardiovascular tissue involvement of the human Mas-related G-protein coupled receptor D (MRGPRD) in the regulation of the inflammatory the observation that MRGPRD mediates the release of IL-6 in an in vitro system, hints at a role as an inflammatory

Expression of GPR84 is strongly up regulated in immune cells in a range of pro-inflammatory settings

signal-regulated kinase [ERK], p38) and redox-sensitive transcription factors (NF-κB) and increased formation of inflammatory OHC-induced allodynia is dependent on MAPK and NF-κB signaling pathways and results in an increase in pro-inflammatory

Regulation of the pro-inflammatory G protein-coupled receptor GPR84. Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory

Sara Marsango and Graeme Milligan for their research on the Regulation of the pro-inflammatory G protein-coupled insights into biological control GPR84 in physiology-Many functions in many tissues Regulation of the pro-inflammatory

However, an imbalance in the chemokine system can also contribute to various diseases, such as inflammatory of leukocytes throughout the body, ensuring a functional immune system and an effective response to inflammatory Scavenging allows cells to continuously migrate by remaining responsive to chemokines, it dampens the inflammatory

interacts with P2RY12 and ameliorates deep venous thrombosis by counteracting neutrophil NETosis and inflammatory DVT formation is a time-dependent inflammatory process in which NETosis plays an important role.

roles in the pathological mechanisms of a wide range of diseases including heart failure, cancer, and inflammatory in immune cell function and focuses on the pathological implications of GRK2/β-arrestin2 in various inflammatory

Genome-scale CRISPR screening reveals that C3aR signaling is critical for rapid capture of fungi by macrophages "The fungal pathogen Histoplasma capsulatum (Hc) invades, replicates within, and destroys macrophages We demonstrated that whereas C3aR is dispensable for macrophage phagocytosis of bacteria and latex beads , it is critical for optimal macrophage capture of pathogenic fungi, including Hc, the ubiquitous fungal and uncover a novel and specific role for C3aR in macrophage recognition of fungi."

from RA patients is involved in leukocyte chemotaxis to the synovium "The rheumatoid arthritis (RA) inflammatory Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response

protein-coupled receptor (GPCR) GPR35 is involved in oncogenic signaling, bacterial infections, and inflammatory modulate GPR35-transducer interactions and allow for mechanism-based therapies against, for example, inflammatory

biopharmaceutical company focused on orally administered therapeutics to treat autoimmune diseases, inflammatory

chemokines and growth factors, which upon release may directly engage pathogens and/or contribute to inflammatory interplay between platelets and NETs and the potential of this alliance to influence the course of inflammatory