Published date September 2, 2024 Abstract "Inflammatory Bowel Disease (IBD) is a chronic inflammatory upregulated expression of most metabolite-sensing GPCRs analysed, which positively correlated with pro-inflammatory Finally, the secretome from siGPR109A M1 macrophages reduced the gene and protein expression of COL1A1 Cosín-Roger Tags GPR109A , IBD , Metabolite-sensing GPCRs , Metabolomic alterations , Microbiota dysbiosis , Pro-inflammatory macrophages Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News

Herein, we investigated the endogenous role of this pro-resolving receptor in modulating macrophage biology The alterations in macrophage phenotype observed in Gpr101 deficient macrophages were maintained following inflammatory challenge. This was linked with an increased inflammatory response in the Gpr101 deficient animals and a reduced Loss of Gpr101 on macrophages disrupted host pro-resolving responses to zymosan challenge with MacGpr101KO

< GPCR News < GPCRs in Oncology and Immunology Leukotriene B4 receptor 2 governs macrophage migration resolve the pro-inflammatory environment. We detected BLT2 expression in bone marrow derived and peritoneal macrophages of mouse models. Transcriptomic analysis of Ltb4r2-/- and WT macrophages suggested a role for BLT2 in macrophage migration implicates it as a potential therapeutic target for inflammatory pathologies."

The effect of breast cancer cell-conditioned media (BC-CM) on the pro-inflammatory phenotype of VSMCs identified that knockout and VSMC-specific knockdown of RGS5 exacerbated accumulation and pyroptosis of pro-inflammatory VSMCs treated with BC-CM displayed enhanced pro-inflammatory phenotype and higher adherent with macrophages findings suggest that tumor microenvironment shifts the function of RGS5 from anti-inflammation to pro-inflammation and induces the pro-inflammatory phenotype of VSMCs that is favorable for tumor metastasis."

For in vitro studies, microglia and peritoneal macrophages were isolated from adult WT mice and treated Results: Single-dose exposure to ethanol by gavage before LPS injection upregulated pro-inflammatory In the isolated microglia and peritoneal macrophages, ethanol also exacerbated the LPS-induced expression of pro-inflammatory cytokines which was mitigated at least partially by synaptamide. Yoo Sun Kim , Hee-Yong Kim Tags Adenylyl cyclase , Cytokines , GPCR , Gavage , Lipopolysaccharide , Macrophages

Oncology and Immunology CCR6 as a Potential Target for Therapeutic Antibodies for the Treatment of Inflammatory Th17 cells express the CCR6 receptor and inflammatory cytokines, including IL-17, IL-21 and IL-22, which are involved in the spread of inflammatory response. The CCL20/CCR6 mechanism plays a crucial role in the recruitment of these pro-inflammatory cells to local

in Oncology and Immunology Expanding role of CXCR2 and therapeutic potential of CXCR2 antagonists in inflammatory chemokine receptor 2 (CXCR2) is G protein-coupled receptor (GPCR) and plays important roles in various inflammatory biological functions, structure-activity relationships and clinical significance of CXCR2 antagonists in inflammatory antagonist , Cancer , Chronic obstructive pulmonary disease (COPD) , Coronavirus disease 2019 (COVID-19) , Inflammatory

Neutrophils can have a pro-inflammatory phenotype or an anti-inflammatory state, but how these states mediated signaling was driven by its ligand, neuropeptide FF (NPFF), which dictated the balance between pro - and anti-inflammatory programming. steady state expressed NPFF, these findings could have broad implications in various infectious and inflammatory

differentially regulate signaling by the receptors CCR1 and CCR5 Published date November 23, 2023 Abstract "Inflammatory chemokines are often elevated in disease settings, where the largest group of CC-chemokines are the macrophage inflammatory proteins (MIP), which are promiscuous for the receptors CCR1 and CCR5.

setting, OGR1 KO mice displayed an increased activation of the immune system and a higher production of pro-inflammatory cytokines by T cells and macrophages.

Deficiency of SCFA would lead to pro-inflammatory immune cell skewing through insufficient G-protein Such pro-inflammatory immune cells may travel to tissues such as the brain, the lung, the kidney etc

inflammation and tissue injury via prosaposin-GPR37 signaling Published date July 11, 2023 Abstract "Macrophages We report that efferocyte-derived EVs express prosaposin, which binds to macrophage GPR37 to increase efferocyte-derived EVs in a murine model of atherosclerosis is associated with an increase in lesional macrophage Thus, we establish a critical role for efferocyte-derived vesicular mediators in increasing macrophage Subramanian Tags CP: Immunology , GPCR , atherosclerosis , efferocytosis , inflammation resolution , macrophage

downregulating G protein-coupled receptor class C group 5 member A expression on lipopolysaccharide-induced inflammatory of G protein-coupled receptor class C group 5 member A (GPRC5A) on lipopolysaccharide (LPS)-induced inflammatory The mRNA and protein levels of GPRC5A in GFs under 1 mg/L LPS-induced GFs inflammatory state were evaluated RT-qPCR was used to detect the gene expression levels of the inflammatory cytokines in GFs induced by those in the NC group (all P<0.001). siGPRC5A significantly suppressed LPS-induced expressions of these inflammatory

Itaconate (ITA) rapidly accumulates to high levels in myeloid cells under infectious and sterile inflammatory Administration of ITA protects against inflammatory diseases and blockade of ITA production enhances proteins and mechanisms, and conjecture a rationale for developing ITA-based therapeutics to treat inflammatory Authors Dan Ye , Pu Wang , Lei-Lei Chen , Kun-Liang Guan , Yue Xiong Tags IRG1/ACOD1 , cancer , inflammatory

myeloid-lineage cells, including neutrophils (CD11b + Gr1+), monocytes (CD11b + Gr1-Ly6C+ and CD11b + Gr1-Ly6C-), macrophages dendritic cells and that targeting GPR141 may be a possible therapeutic intervention for modulating chronic inflammatory

Nitric acid (NO) inhibition was tested on the macrophage cell line RAW264.7. identified active compounds in Jinqiancao granules that have synergistic mechanisms, contributing to anti-inflammatory

addition, RGS6 overexpression decreased ROS production as well as proinflammatory factor transcription in macrophages Conclusions: RGS6 plays a protective role in ALI not only in early inflammatory responses but also in

This protein ligand plays an important role in obesity and inflammatory processes. This may help to develop more potent ligands for the treatment of inflammatory related diseases."

adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages (LUAD) patients, closely related to their prognosis and positively correlated with tumor-associated macrophages Tags A2aR , Lung adenocarcinoma , Migration , Polarization , Targeted therapy , Tumor-associated macrophages

α2A-adrenergic receptor in intestinal stem cells to exacerbate colitis Published date May 21, 2024 Abstract "Inflammatory Rongbin Zhou , Sheng Wang , Xinyang Song , Shu Zhu , Wen Pan Tags Enterococcus , IBD , ISCs , colitis , inflammatory

large family of G protein-coupled receptors (GPCRs), are critical for the elimination of pathogens and inflammatory NADPH oxidase advance our understanding of the role of receptor transactivation in the regulation of inflammatory

leukocyte chemotaxis to the synovium Published date November 1, 2022 Abstract The rheumatoid arthritis (RA) inflammatory Recent evidence indicates that GPR15 may be associated with modulation of the chronic inflammatory response

leukocytes via directed migration (also referred to as chemotaxis) is a common pathogenic mechanism of inflammatory These findings have implications for therapeutically targeting TIPE proteins in human inflammatory and

In addition, GSEA showed that GPR37 was positively correlated to the positive regulation of macrophage expression was significantly associated with the infiltration of T cells, CD8 T cell, eosinophils, macrophages In addition, high GPR37 expression was positively correlated with increased infiltration of M2 macrophages Degui Liao , Miaoling Lai , Huaidong Peng , Yanbin Ke , Zhaotao Wang , Yezhong Wang Tags GPR37 , M2 macrophages

, our findings propose a therapeutic potential in combined CXCR4 and LPA1 inhibitors for cancer and inflammatory Chemokine receptor 4 , Chemotaxis , G protein-coupled receptor , GPCR heteromer , GPCR signaling , Inflammatory

profile GPCR transcripts in white blood cells (WBCs)-B, CD4, CD8, NK, and dendritic cells; monocytes, and macrophage-like monocytes treated with granulocyte-macrophage colony-stimulating factor-as well as platelets.

including Type 2 Diabetes and other indications including non-alcoholic steatohepatitis (NASH) and inflammatory

targeting GPCR ( Confo Therapeutics ) as a team and project leader for antibody discovery for metabolic and inflammatory