Search Results
41 items found for "Prognostic biomarker"
- Expression pattern and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic indicator and future therapeutic target
and clinical significance of beta 2-adrenergic receptor in oral squamous cell carcinoma: an emerging prognostic is significantly overexpressed in various types of malignancies, which is associated with the worst prognosis In the Cox proportional hazards model, β2-AR was identified as a prognostic biomarker of OSCC (p = 0.047 Conclusion: β2-AR protein level is identified as an independent significant prognostic factor in patients Mohanty, Rajender Singh, Vijay Kumar, Uma Shankar Singh, Rakesh Kumar Singh Tags GPCR; OSCC; Oral cancer; Prognostic
- The path of GPR87: from a P2Y-like receptor to its role in cancer progression
Furthermore, the importance of the expression of GPR87 as a predictive biomarker for evaluating the prognosis Authors Katrin Sak Tags Carcinogenesis , GPR87 , LPA receptor , Metastasis , Orphan GPCR , P2Y receptor , Prognostic biomarker Source Contribute to the GPCR News Coming soon Become a Contributor Classified GPCR News GPCR
- Comparative Analysis of the GNAI Family Genes in Glioblastoma through Transcriptomics and Single-Cell Technologies
Hence, identifying the crucial pathways and biomarkers for the treatment of GBM is of prime importance We investigated the prognostic values of the guanine nucleotide-binding protein G(i) alpha subunit (GNAI Our findings suggest that the GNAI3 gene holds potential as a prognostic biomarker for GBM. Chih-Yang Wang Tags G-protein-coupled receptor (GPCR) , genome , glioblastoma , malignancy , molecular biomarker , prognosis , signaling pathway .
- Identification of a G-protein coupled receptor-related gene signature through bioinformatics analysis to construct a risk model for ovarian cancer prognosis
Prognostic GPCRRGs were screened using least absolute shrinkage and selection operator (LASSO) Cox regression analysis, and a prognostic model was constructed. K-M analysis of the prognostic model showed that it could differentiate high- and low-risk patients, Conclusions: Our prognostic model elaborates on the roles of GPCRRGs in OV and provides a new tool for Chunfang Ha Tags G protein-coupled receptor , Immune infiltration , Molecular marker , Ovarian cancer , Prognostic
- GPR37 expression as a prognostic marker in gliomas: a bioinformatics-based analysis
< GPCR News < GPCRs in Oncology and Immunology GPR37 expression as a prognostic marker in gliomas: a explore the relationship between GPR37 gene expression and the clinicopathological factors, patient prognosis significantly higher in the glioma tissues compared to the normal brain tissues, and was linked to poor prognosis Conclusion: GPR37 had diagnostic and prognostic value in glioma. Yanbin Ke , Zhaotao Wang , Yezhong Wang Tags GPR37 , M2 macrophages , glioma , immune infiltration , prognosis
- Exploration of prognostic and treatment markers in hepatocellular carcinoma via GPCR-related genes analysis
< GPCR News < GPCRs in Oncology and Immunology Exploration of prognostic and treatment markers in hepatocellular (HCC) was elucidated, and GPCR-related genes were employed for building a risk-score model for the prognosis Patients in the high-risk group exhibited a worse prognosis but demonstrated a more favorable immunotherapy Conclusions: In this study, an efficient HCC prognostic prediction model was constructed by only GPCR-related , Jiali Xing , Baoluhe Zhang , Xiaokun Chen , Xiao Liu , Xueshuai Wan , Shunda Du Tags GPCR ; HCC ; Prognosis
- Student Flash Presentations | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
Before joining UAB as a graduate student, he worked in the EuGEF Research Group to identify novel prognostic biomarkers and therapeutic options for Metastatic Breast Cancer (BC) and Head and Neck Squamous Cell
- PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in ovarian cancer
GPCRs in Oncology and Immunology PAXIP1-AS1 is associated with immune infiltration and predicts poor prognosis in OC cell lines, but the relationship between PAXIP1-AS1 expression and clinical characteristics, prognosis were used to evaluate the relationship between clinical characteristics and PAXIP1-AS1 expression, prognostic PAXIP1-AS1 could be a promising prognosis biomarker and response to immunotherapy for OC."
- From odor to oncology: non-canonical odorant receptors in cancer
findings shed light on the potential of non-canonical odorant receptors as therapeutic targets and prognostic
- SSTR2 positively associates with EGFR and predicts poor prognosis in nasopharyngeal carcinoma
GPCR News < GPCRs in Oncology and Immunology SSTR2 positively associates with EGFR and predicts poor prognosis belongs to the receptor tyrosine kinases family and overexpression of EGFR has been linked to poor prognosis expression of SSTR2, high expression of EGFR, and high coexpression of SSTR2 and EGFR had a poorer prognosis Additionally, SSTR2 has potential as a new biomarker for poor prognosis in NPC patients." Authors Yue Xu, Zihan Quan, Yuting Zhan, Haihua Wang, Jiadi Luo, Weiyuan Wang, Songqing Fan Tags biomarkers
- Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking
Survival analysis established the clinical prognostic relevance of identified hub genes in cancer.
- Deciphering a GPCR-lncRNA-miRNA Nexus: Identification of an Aberrant Therapeutic Target in Ovarian Cancer
correlates with survival outcomes and therapy response in ovarian cancer clinical samples, underscoring its prognostic
- Molecular characterization of breast cancer cell pools with normal or reduced ability to respond to progesterone: a study based on RNA-seq
PR is an important prognostic factor in breast cancer.
- Regulator of G protein signaling 16 restrains apoptosis in colorectal cancer through disrupting TRAF6-TAB2-TAK1-JNK/p38 MAPK signaling
Colorectal cancer (CRC) remains a major global cause of cancer-related mortality, lacking effective biomarkers 899 CRC tissues revealed elevated RGS16 levels, correlating with clinicopathological features and CRC prognosis
- Identification of S1PR4 as an immune modulator for favorable prognosis in HNSCC through machine learning
News < GPCRs in Oncology and Immunology Identification of S1PR4 as an immune modulator for favorable prognosis
- Agonists of galanin subtype 2 receptor may prevent pancreatic cancer and agonists of angiotensin II type 2 receptor may prevent colorectal cancer
June 24, 2024 Abstract "Pancreatic ductal adenocarcinoma (PDAC) remains a dreadful disease with poor prognosis While the prognosis of colorectal carcinoma (CRC) is better than that of PDAC, it still is the second-leading
- Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers beyond NET: a paired immunohistochemistry approach
and Immunology Expression prevalence and dynamics of GPCR somatostatin receptors 2 and 3 as cancer biomarkers approach Published date November 27, 2023 Abstract "Somatostatin receptors are clinically validated GPCR biomarkers We suggest that SST2 and SST3 should be further explored as potential biomarkers and therapeutic tools
- Activation of PI3K/Akt pathway by G protein-coupled receptor 37 promotes resistance to cisplatin-induced apoptosis in non-small cell lung cancer
tumors, particularly in non-small-cell lung cancer (NSCLC) METHODS: We explored the expression and prognosis We found that elevated GPR37 expression predicts an unfavorable prognosis. (2) It was demonstrated that
- miR-19a may function as a biomarker of oral squamous cell carcinoma (OSCC) by regulating the signaling pathway of miR-19a/GRK6/GPCRs/PKC in a Chinese population
< GPCR News < GPCRs in Oncology and Immunology miR-19a may function as a biomarker of oral squamous cell
- Posters | Adhesion GPCR Workshop 2024 | Dr. GPCR Ecosystem
identifying which will progress to invasive disease remains difficult highlighting an urgent need for new biomarkers Recent studies identify CELSR1, a key PCP gene, as a novel biomarker for early-stage breast cancer. of CELSR1, which would be missed in gene expression microarray analyses, we hope to illuminate the prognostic
- Unbiased multitissue transcriptomic analysis reveals complex neuroendocrine regulatory networks mediated by spinal cord injury-induced immunodeficiency
Several studies have suggested that SCI-IDS is an independent risk factor for poor neurological prognosis immunosuppression in the periphery results in increased susceptibility to infection, leading to poor neurological prognosis
- A virally encoded GPCR drives glioblastoma through feed-forward activation of the SK1-S1P1 signaling axis
associated with accelerated progression of glioblastomas, aggressive brain tumors with a generally poor prognosis
- A2aR on lung adenocarcinoma cells: A novel target for cancer therapy via recruiting and regulating tumor-associated macrophages
specifically expressed on tumor cells from lung adenocarcinoma (LUAD) patients, closely related to their prognosis
- In Silico Design of Novel RGS2-Galpha-q Interaction Inhibitors with Anticancer Activity
cancers, and its levels in prostate cancer significantly correlate with the metastatic stage and poor prognosis
- Simultaneous activation of CXC chemokine receptor 4 and histamine receptor H1 enhances calcium signaling and cancer cell migration
cancer cell lines and cancer tissues and that coexpression of CXCR4 and HRH1 is associated with poor prognosis
- The combination of brentuximab vedotin and chidamide synergistically suppresses the proliferation of T-cell lymphoma cells through the enhancement of apoptosis
3, 2023 Abstract " Purpose: Peripheral T-cell lymphoma (PTCL) is an aggressive disease with a poor prognosis
- Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell therapy
Bispecific antibodies seemed to overcome the poor prognosis associated with early relapse and EMD, and
- RGS20 promotes non-small cell lung carcinoma proliferation via autophagy activation and inhibition of the PKA-Hippo signaling pathway
Our study aimed to identify the role of RGS20 in NSCLC prognosis and delineate associated cellular and